The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions

CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease

(2015) Stephen I. Rennard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis

(2015) Anthony De Soyza et al.   EUROPEAN RESPIRATORY JOURNAL

The safety and tolerability of oral AZD5069, a selective CXCR2 antagonist, in patients with moderate-to-severe COPD

(2015) A.M. Kirsten et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Humoral immunity and delayed-type hypersensitivity in healthy subjects treated for 30days with MK-7123, a selective CXCR2 antagonist

(2013) Michael Seiberling et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Circulating neutrophil dysfunction in acute liver failure

(2012) Nicholas J. Taylor et al.   HEPATOLOGY

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

(2011) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor

(2011) R. Virtala et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

(2010) Janesh Pillay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prosurvival activity for airway neutrophils in severe asthma

(2010) M. Uddin et al.   THORAX

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

(2009) O. Holz et al.   EUROPEAN RESPIRATORY JOURNAL

Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues

(2008) A. E. Cardona et al.   BLOOD

Ammonia impairs neutrophil phagocytic function in liver disease

(2008) Debbie L. Shawcross et al.   HEPATOLOGY

CXCR2 antagonists for the treatment of pulmonary disease

(2008) R.W. Chapman et al.   PHARMACOLOGY & THERAPEUTICS

Characterisation of the range of neutrophil stimulating mediators in cystic fibrosis sputum

(2008) K J Mackerness et al.   THORAX

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor

(2007) M. Uddin et al.   EUROPEAN RESPIRATORY JOURNAL