Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selected Aspects of Chemoresistance Mechanisms in Colorectal Carcinoma—A Focus on Epithelial-to-Mesenchymal Transition, Autophagy, and Apoptosis

(2019) Veronika Skarkova et al.   Cells

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer

(2019) Xiaowei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MCL1 and DEDD Promote Urothelial Carcinoma Progression

(2019) Andrew L. Hong et al.   MOLECULAR CANCER RESEARCH

Degrading proteins in animals: “PROTAC”tion goes in vivo

(2019) Jianping Guo et al.   CELL RESEARCH

DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer

(2019) Qi Zhang et al.   CELL DEATH AND DIFFERENTIATION

JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1

(2019) Xiaowei Wu et al.   CELL DEATH AND DIFFERENTIATION

Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma

(2019) Dana Prukova et al.   CLINICAL CANCER RESEARCH

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1 (MCL1)

(2019) James William Papatzimas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells

(2019) Bin Hu et al.   Cells

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer

(2019) Xiaojun Man et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity

(2019) Zoltan Szlávik et al.   JOURNAL OF MEDICINAL CHEMISTRY

AZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells.

(2019) Justin Cidado et al.   CLINICAL CANCER RESEARCH

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia

(2019) Raoul Tibes et al.   Frontiers in Oncology

ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2

(2018) Qingyu Luo et al.   CANCER LETTERS

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest

(2018) Lindsey A Allan et al.   EMBO JOURNAL

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

(2018) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells

(2018) Zhaodong Li et al.   LEUKEMIA

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

(2018) Silvia Escudero et al.   MOLECULAR CELL

MCL-1 is a prognostic indicator and drug target in breast cancer

(2018) Kirsteen J. Campbell et al.   Cell Death & Disease

Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers

(2018) D Głodzik et al.   ANNALS OF ONCOLOGY

Experimental Characterization of the Binding Affinities between Proapoptotic BH3 Peptides and Antiapoptotic Bcl-2 Proteins

(2018) Wenna Kong et al.   ChemMedChem

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

(2018) Nicole Prutsch et al.   LEUKEMIA

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

(2018) Donia M. Moujalled et al.   LEUKEMIA

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

(2018) Xin Jin et al.   MOLECULAR CELL

A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute Myelogenous Leukemia

(2018) Haley E. Ramsey et al.   Cancer Discovery

Exploiting MCL-1 dependency with combination MEK + MCL-1 inhibitors leads to induction of apoptosis and tumor regression in KRAS mutant non-small cell lung cancer

(2018) Varuna Nangia et al.   Cancer Discovery

STAT3- and GSK3β-mediated Mcl-1 regulation modulates TPF resistance in oral squamous cell carcinoma

(2018) Santanu Maji et al.   CARCINOGENESIS

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

(2018) Natasha S. Anstee et al.   CELL DEATH AND DIFFERENTIATION

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

(2018) Aditi Shastri et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

(2017) Guo Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor

(2017) Xiaofeng Wu et al.   NATURE CELL BIOLOGY

Structural basis of PROTAC cooperative recognition for selective protein degradation

(2017) Morgan S Gadd et al.   Nature Chemical Biology

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

(2017) Avi Ashkenazi et al.   NATURE REVIEWS DRUG DISCOVERY

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

(2017) S Hernández-Pérez et al.   ONCOGENE

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1

(2017) Xiaofang Wang et al.   VIRAL IMMUNOLOGY

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

(2017) Akane Inoue-Yamauchi et al.   Nature Communications

Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue

(2017) Khaled Alsayegh et al.   Scientific Reports

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

(2016) S Grabow et al.   Cell Death & Disease

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

(2016) Stephanie Grabow et al.   Cell Reports

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

(2015) Irina Kiprianova et al.   NEOPLASIA

Deubiquitinase USP9x Confers Radioresistance through Stabilization of Mcl-1

(2015) Donatella Trivigno et al.   NEOPLASIA

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

(2014) B Wang et al.   CELL DEATH AND DIFFERENTIATION

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

(2014) G. L. Kelly et al.   GENES & DEVELOPMENT

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X

(2014) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages

(2014) I. Dzhagalov et al.   JOURNAL OF IMMUNOLOGY

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

MCL1 is critical for mitochondrial function and autophagy in the heart

(2013) Robert L Thomas et al.   Autophagy

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

(2013) R. L. Thomas et al.   GENES & DEVELOPMENT

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

(2013) X. Wang et al.   GENES & DEVELOPMENT

JosD1, a Membrane-targeted Deubiquitinating Enzyme, Is Activated by Ubiquitination and Regulates Membrane Dynamics, Cell Motility, and Endocytosis

(2013) Takahiro Seki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Profiling of the Residual Disease of Triple-Negative Breast Cancers after Neoadjuvant Chemotherapy Identifies Actionable Therapeutic Targets

(2013) J. M. Balko et al.   Cancer Discovery

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors

(2012) Wajana L. Labisso et al.   CELL CYCLE

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

(2012) M M Magiera et al.   CELL DEATH AND DIFFERENTIATION

BH3-only proteins in apoptosis at a glance

(2012) L. Happo et al.   JOURNAL OF CELL SCIENCE

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

(2012) Pedro A. Pérez-Mancera et al.   NATURE

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Delving deeper: MCL-1's contributions to normal and cancer biology

(2012) Rhonda M. Perciavalle et al.   TRENDS IN CELL BIOLOGY

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

(2011) Patricia Gomez-Bougie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

(2011) H. Sun et al.   BLOOD

Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition

(2011) J. L. Coloff et al.   CANCER RESEARCH

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MCL1 meets its end during mitotic arrest

(2011) Scott E Millman et al.   EMBO REPORTS

The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition

(2011) XIAOFEI WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

(2010) P Pawlikowska et al.   CELL DEATH AND DIFFERENTIATION

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

(2010) Marc Germain et al.   EMBO JOURNAL

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

(2010) Yaron Pereg et al.   NATURE CELL BIOLOGY

Protacs for Treatment of Cancer

(2010) Kathleen M Sakamoto   PEDIATRIC RESEARCH

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

(2010) W J Placzek et al.   Cell Death & Disease

FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation

(2009) G. Yoshimoto et al.   BLOOD

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

(2009) Hayato Hikita et al.   HEPATOLOGY

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

(2009) Achim Weber et al.   HEPATOLOGY

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IFN-  and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

(2008) G. B. Lesinski et al.   CANCER RESEARCH

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation

(2008) Sarwat Jamil et al.   MOLECULAR BIOLOGY OF THE CELL