Experimental Characterization of the Binding Affinities between Proapoptotic BH3 Peptides and Antiapoptotic Bcl-2 Proteins

Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats

(2018) Ke-Zheng Dai et al.   JOURNAL OF IMMUNOLOGY

Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides

(2017) Vivek Modi et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

(2017) Richard W. Birkinshaw et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells

(2016) Michael Butterworth et al.   BRITISH JOURNAL OF CANCER

Energetics and Dynamics Across the Bcl-2-Regulated Apoptotic Pathway Reveal Distinct Evolutionary Determinants of Specificity and Affinity

(2016) Stefan M. Ivanov et al.   STRUCTURE

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

Mutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis

(2015) Linjie Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

(2015) Hoang Nguyen et al.   SENSORS

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

The Bcl-2 family: structures, interactions and targets for drug discovery

(2014) Marc Kvansakul et al.   APOPTOSIS

Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles

(2014) Jing Tang et al.   CURRENT PHARMACEUTICAL DESIGN

Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins

(2013) Jianting Long et al.   BMC BIOTECHNOLOGY

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins

(2012) Laura Delgado-Soler et al.   Journal of Chemical Information and Modeling

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mitochondrial signaling in cell death via the Bcl-2 family

(2010) Brian Leibowitz et al.   CANCER BIOLOGY & THERAPY

Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins

(2009) Erinna F. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim

(2008) Maria Dolores Herman et al.   FEBS LETTERS

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

(2008) Erinna F. Lee et al.   JOURNAL OF CELL BIOLOGY