JosD1, a Membrane-targeted Deubiquitinating Enzyme, Is Activated by Ubiquitination and Regulates Membrane Dynamics, Cell Motility, and Endocytosis

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

(2012) Antje Schaefer et al.   BIOCHEMICAL JOURNAL

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate

(2012) Christian M. Loch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ubiquitin-mediated regulation of RhoGTPase signalling: IAPs and HACE1 enter the fray

(2012) Mariam Orme et al.   EMBO JOURNAL

The role of ubiquitylation in receptor endocytosis and endosomal sorting

(2012) K. Haglund et al.   JOURNAL OF CELL SCIENCE

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat

(2012) M. Al Soraj et al.   JOURNAL OF CONTROLLED RELEASE

Establishment of a Novel Fluorescence-Based Method to Evaluate Chaperone-Mediated Autophagy in a Single Neuron

(2012) Takahiro Seki et al.   PLoS One

Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes

(2012) Wei-Ling Tsou et al.   PLoS One

Regulation of cellular responses by deubiquitinating enzymes: an update

(2011) James et al.   Frontiers in Bioscience-Landmark

Ubiquitin-specific proteases as cancer drug targets

(2011) Wolfgang Sippl et al.   Future Oncology

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

Balancing act: deubiquitinating enzymes in the nervous system

(2011) Sokol V. Todi et al.   TRENDS IN NEUROSCIENCES

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

Crystal Structure of a Josephin-Ubiquitin Complex

(2010) Stephen D. Weeks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

(2010) Sokol V. Todi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

(2009) Sokol V Todi et al.   EMBO JOURNAL

Negative Guidance Factor-Induced Macropinocytosis in the Growth Cone Plays a Critical Role in Repulsive Axon Turning

(2009) A. L. Kolpak et al.   JOURNAL OF NEUROSCIENCE

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The UBA-UIM Domains of the USP25 Regulate the Enzyme Ubiquitination State and Modulate Substrate Recognition

(2009) Amanda Denuc et al.   PLoS One

The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63Linkages in Mixed Linkage Ubiquitin Chains

(2008) Brett J. Winborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse

(2008) Hiroyuki Kabayama et al.   MOLECULAR AND CELLULAR NEUROSCIENCE