Organoid technology in female reproductive biomedicine

Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models

(2020) Nina Maenhoudt et al.   Stem Cell Reports

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

(2019) Mirjana Kessler et al.   Nature Communications

A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract

(2019) Megan E. Spurgeon et al.   mBio

Efficient use of patient-derived organoids as a preclinical model for gynecologic tumors

(2019) Yoshiaki Maru et al.   GYNECOLOGIC ONCOLOGY

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Establishment and characterization of patient‐derived organoids from a young patient with cervical clear cell carcinoma

(2019) Yoshiaki Maru et al.   CANCER SCIENCE

Human placenta and trophoblast development: key molecular mechanisms and model systems

(2019) Martin Knöfler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Organoids are promising tools for species‐specific in vitro toxicological studies

(2019) Justyna Augustyniak et al.   JOURNAL OF APPLIED TOXICOLOGY

The single-cell sequencing: new developments and medical applications

(2019) Xiaoning Tang et al.   Cell and Bioscience

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

(2019) Matteo Boretto et al.   NATURE CELL BIOLOGY

Recent Progress in Light Sheet Microscopy for Biological Applications

(2018) Krishnendu Chatterjee et al.   APPLIED SPECTROSCOPY

Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy

(2018) Ramyar Azizi et al.   BIOMEDICINE & PHARMACOTHERAPY

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

(2018) Susan Tsai et al.   BMC CANCER

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Human mesenchymal stem cells in spheroids improve fertility in model animals with damaged endometrium

(2018) Alisa Domnina et al.   Stem Cell Research & Therapy

Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube

(2018) Ying Xie et al.   Stem Cell Research

Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

(2018) Sarah J. Hill et al.   Cancer Discovery

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Microphysiologic systems in female reproductive biology

(2017) Alexandria N Young et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Use of Endometrial Cancer Patient–Derived Organoid Culture for Drug Sensitivity Testing Is Feasible

(2017) Eugenia Girda et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Recent Advances in CRISPR-Cas9 Genome Editing Technology for Biological and Biomedical Investigations

(2017) Vijai Singh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Trophoblast lineage specification, differentiation and their regulation by oxygen tension

(2017) Ching-Wen Chang et al.   JOURNAL OF ENDOCRINOLOGY

3D Spheroid/Organoid Models of Lung Cancer to Study Lung Cancer Pathogenesis and Testing of New Therapeutics

(2017) B. Gao et al.   Journal of Thoracic Oncology

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

Cancer-Associated Mutations in Endometriosis without Cancer

(2017) Michael S. Anglesio et al.   NEW ENGLAND JOURNAL OF MEDICINE

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic

(2017) A D Marshall et al.   ONCOGENE

CD34+mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

(2017) Igor Stzepourginski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New use of microsatellite instability analysis in endometrial cancer

(2017) Haruko Kunitomi et al.   Oncology Letters

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells

(2017) Venkata Ramesh Dasari et al.   Oncotarget

Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium

(2017) Nur Yucer et al.   Scientific Reports

Organ-on-a-Chip Systems for Women's Health Applications

(2017) Janna Nawroth et al.   Advanced Healthcare Materials

Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

(2017) NaiLi Wei et al.   Stem Cells International

Human Extravillous Trophoblasts Penetrate Decidual Veins and Lymphatics before Remodeling Spiral Arteries during Early Pregnancy

(2017) Nannan He et al.   PLoS One

Designing 3-Dimensional In Vitro Oviduct Culture Systems to Study Mammalian Fertilization and Embryo Production

(2016) Marcia A. M. M. Ferraz et al.   ANNALS OF BIOMEDICAL ENGINEERING

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Intestinal organoids and personalized medicine in cystic fibrosis

(2016) Jacquelien Noordhoek et al.   CURRENT OPINION IN PULMONARY MEDICINE

Pelvic inflammatory disease and salpingitis: incidence of primary and repeat episodes in England

(2016) M. J. PRICE et al.   EPIDEMIOLOGY AND INFECTION

Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs

(2016) Kimberly C. Brannen et al.   ILAR JOURNAL

Mouse Models for Drug Discovery. Can New Tools and Technology Improve Translational Power?

(2016) Aamir Zuberi et al.   ILAR JOURNAL

Stromal Clues in Endometrial Carcinoma

(2016) Serkan Senol et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Endometrial cancer

(2016) Philippe Morice et al.   LANCET

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Modeling the Dynamics of High-Grade Serous Ovarian Cancer Progression for Transvaginal Ultrasound-Based Screening and Early Detection

(2016) Dana-Adriana Botesteanu et al.   PLoS One

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy

(2016) Peta Grigsby   SEMINARS IN REPRODUCTIVE MEDICINE

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

(2016) Cheryl Q.E. Lee et al.   Stem Cell Reports

What is the placenta?

(2015) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Estrogen and phenol red free medium for osteoblast culture: study of the mineralization ability

(2015) A. N. de Faria et al.   CYTOTECHNOLOGY

Human CD133+ bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome

(2015) Irene Cervelló et al.   FERTILITY AND STERILITY

Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells

(2015) Jessica L. Forbester et al.   INFECTION AND IMMUNITY

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

(2015) Melina Arnold et al.   LANCET ONCOLOGY

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Influence of Cancer-Associated Endometrial Stromal Cells on Hormone-Driven Endometrial Tumor Growth

(2015) M. J. Pineda et al.   Hormones & Cancer

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Microphysiological modeling of the reproductive tract: A fertile endeavor

(2014) Sharon L Eddie et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Preventive effect of oral mucosal epithelial cell sheets on intrauterine adhesions

(2014) G. Kuramoto et al.   HUMAN REPRODUCTION

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome

(2014) Feryal Alawadhi et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Notch signaling in serous ovarian cancer

(2014) Jolijn W Groeneweg et al.   Journal of Ovarian Research

The role of the fallopian tube in the origin of ovarian cancer

(2013) Britt K. Erickson et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Technological Overview of iPS Induction from Human Adult Somatic Cells

(2013) Emilie Bayart et al.   CURRENT GENE THERAPY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Comparison of extravillous trophoblast cells derived from human embryonic stem cells and from first trimester human placentas

(2013) B.P. Telugu et al.   PLACENTA

U-Shape Suppressive Effect of Phenol Red on the Epileptiform Burst Activity via Activation of Estrogen Receptors in Primary Hippocampal Culture

(2013) Xu Liu et al.   PLoS One

Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation

(2013) Kathryn L. Chapman et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In-vitro model systems for the study of human embryo–endometrium interactions

(2013) Charlotte H.E. Weimar et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Does Bacterial Vaginosis Cause Pelvic Inflammatory Disease?

(2013) Brandie DePaoli Taylor et al.   SEXUALLY TRANSMITTED DISEASES

Recreating the female reproductive tract in vitro using iPSC technology in a linked microfluidics environment

(2013) Monica M Laronda et al.   Stem Cell Research & Therapy

CFTR, Mucins, and Mucus Obstruction in Cystic Fibrosis

(2013) S. M. Kreda et al.   Cold Spring Harbor Perspectives in Medicine

Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

(2013) Valerie C. Henderson et al.   PLOS MEDICINE

HTR8/SVneo Cells Display Trophoblast Progenitor Cell-Like Characteristics Indicative of Self-Renewal, Repopulation Activity, and Expression of “Stemness-” Associated Transcription Factors

(2013) Maja Weber et al.   Biomed Research International

Endometrial reconstruction from stem cells

(2012) Caroline E. Gargett et al.   FERTILITY AND STERILITY

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Chlamydia trachomatis Infection Increases Fallopian Tube PROKR2 via TLR2 and NFκB Activation Resulting in a Microenvironment Predisposed to Ectopic Pregnancy

(2011) Julie L.V. Shaw et al.   AMERICAN JOURNAL OF PATHOLOGY

Cervico-Vaginal Tissue Ex Vivo as a Model to Study Early Events in HIV-1 Infection

(2011) Melanie Merbah et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

The dark side of induced pluripotency

(2011) Martin F. Pera   NATURE

Placental and trophoblastic in vitro models to study preventive and therapeutic agents for preeclampsia

(2011) K. Orendi et al.   PLACENTA

Apoptosis is Induced in Chlamydia trachomatis-infected HEp-2 Cells by the Addition of a Combination Innate Immune Activation Compounds and the Inhibitor Wedelolactone

(2010) Wilhelmina M. Huston et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory

(2010) Robert J. Kurman et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Fallopian Tube

(2010) Shannon Salvador et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Analysis of modulated gene expression in a model of Interferon-γ-induced persistence of Chlamydia trachomatis in HEp-2 cells

(2010) Abas Kokab et al.   MICROBIAL PATHOGENESIS

Critical evaluation of human endometrial explants as an ex vivo model system: a molecular approach

(2010) W. R. Schafer et al.   MOLECULAR HUMAN REPRODUCTION

Female reproductive tract infections: understandings and care seeking behaviour among women of reproductive age in Lagos, Nigeria

(2010) Kabiru A Rabiu et al.   BMC Womens Health

Development and Characterization of a Three-Dimensional Organotypic Human Vaginal Epithelial Cell Model1

(2009) Brooke E. Hjelm et al.   BIOLOGY OF REPRODUCTION

Sex Differences in Pharmacokinetics and Pharmacodynamics

(2009) Offie P. Soldin et al.   CLINICAL PHARMACOKINETICS

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection

(2008) A. E. King et al.   HUMAN REPRODUCTION

Combined Effect of Gender and Caloric Restriction on Liver Proteomic Expression Profile

(2008) Adamo Valle et al.   JOURNAL OF PROTEOME RESEARCH

Fertilization and Early Embryonic Development in the Porcine Fallopian Tube

(2008) K-P Brssow et al.   REPRODUCTION IN DOMESTIC ANIMALS