Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs

A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds

(2016) Karen Augustine-Rauch et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Advancements in zebrafish applications for 21st century toxicology

(2016) Gloria R. Garcia et al.   PHARMACOLOGY & THERAPEUTICS

Animals and the 3Rs in toxicology research and testing

(2015) WS Stokes   HUMAN & EXPERIMENTAL TOXICOLOGY

From cutting edge to guideline: A first step in harmonization of the zebrafish embryotoxicity test (ZET) by describing the most optimal test conditions and morphology scoring system

(2015) Manon Beekhuijzen et al.   REPRODUCTIVE TOXICOLOGY

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay

(2015) Julieta M. Panzica-Kelly et al.   TOXICOLOGICAL SCIENCES

Influence of the perivitelline space on the quantification of internal concentrations of chemicals in eggs of zebrafish embryos (Danio rerio)

(2014) Stephan Brox et al.   AQUATIC TOXICOLOGY

Primary Cell Cultures for Understanding Rat Epididymal Inflammation

(2014) Robert E. Chapin et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Improvement of the evaluation method for teratogenicity using zebrafish embryos

(2014) Akihito Yamashita et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Generation of male differentiated germ cells from various types of stem cells

(2014) Jingmei Hou et al.   REPRODUCTION

More than just hormones: H295R cells as predictors of reproductive toxicity

(2014) Jodi M. Maglich et al.   REPRODUCTIVE TOXICOLOGY

Fishing for Teratogens: A Consortium Effort for a Harmonized Zebrafish Developmental Toxicology Assay

(2014) Jonathan S. Ball et al.   TOXICOLOGICAL SCIENCES

An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods

(2014) Miguel A. Sogorb et al.   TOXICOLOGY LETTERS

Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

(2013) Jessica A. Palmer et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches

(2012) Jan Willem van der Laan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Alternative models in developmental toxicology

(2012) Hyung-yul Lee et al.   Systems Biology in Reproductive Medicine

Development of a Streamlined Rat Whole Embryo Culture Assay for Classifying Teratogenic Potential of Pharmaceutical Compounds

(2012) Cindy Zhang et al.   TOXICOLOGICAL SCIENCES

Establishment of a Molecular Embryonic Stem Cell Developmental Toxicity Assay

(2012) Julieta M. Panzica-Kelly et al.   TOXICOLOGICAL SCIENCES

Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design

(2011) Jason Thomson et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Zebrafish-As an integrative model for twenty-first century toxicity testing

(2011) Nisha S. Sipes et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Contribution of myo-inositol and melatonin to human reproduction

(2011) G. Carlomagno et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

In vitro production of functional sperm in cultured neonatal mouse testes

(2011) Takuya Sato et al.   NATURE

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

(2011) Kathleen Van den Bulck et al.   REPRODUCTIVE TOXICOLOGY

Mouse embryonic stem cell adherent cell differentiation and cytotoxicity (ACDC) assay

(2011) Marianne Barrier et al.   REPRODUCTIVE TOXICOLOGY

Feasibility study of the zebrafish assay as an alternative method to screen for developmental toxicity and embryotoxicity using a training set of 27 compounds

(2011) Ingrid W.T. Selderslaghs et al.   REPRODUCTIVE TOXICOLOGY

Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I

(2011) A.-L. Gustafson et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

(2011) S. Padilla et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

(2011) Stefan Weigt et al.   TOXICOLOGY

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies

(2011) Sanne A.B. Hermsen et al.   TOXICOLOGY IN VITRO

Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)

(2010) Jens C. Otte et al.   AQUATIC TOXICOLOGY

A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture

(2010) Cindy X. Zhang et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Development of a zebrafish embryo teratogenicity assay and quantitative prediction model

(2010) Kimberly C. Brannen et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays

(2010) Karen Augustine-Rauch et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

Dechorionation as a tool to improve the fish embryo toxicity test (FET) with the zebrafish (Danio rerio)

(2010) Kirsten Henn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

The predictivity of preliminary embryo-fetal development (EFD) studies: results of a retrospective survey in Japanese pharmaceutical companies

(2010) Noriko Okahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Validation of a Rat Seminiferous Tubule Culture Model as a Suitable System for Studying Toxicant Impact on Meiosis Effect of Hexavalent Chromium

(2010) Cendrine Geoffroy-Siraudin et al.   TOXICOLOGICAL SCIENCES

Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos

(2010) Stefan Weigt et al.   TOXICOLOGY

Oxidative and Conjugative Xenobiotic Metabolism in Zebrafish Larvae In Vivo

(2010) Huw S. Jones et al.   Zebrafish

In vitro post-meiotic germ cell development from human embryonic stem cells

(2009) B. Aflatoonian et al.   HUMAN REPRODUCTION

Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates

(2009) Xiaozhong Yu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry

(2008) Jennifer A. Paquette et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish

(2008) Robert Chapin et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Zebrafish: a predictive model for assessing drug-induced toxicity

(2008) Patricia McGrath et al.   DRUG DISCOVERY TODAY

The in vitro growth and maturation of follicles

(2008) H M Picton et al.   REPRODUCTION

Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)

(2008) François Busquet et al.   TOXICOLOGICAL SCIENCES