Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

An update on stem cell biology and engineering for brain development

(2017) C J C Parr et al.   MOLECULAR PSYCHIATRY

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

(2017) Abbas H Rizvi et al.   NATURE BIOTECHNOLOGY

The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

(2017) Derek K. Smith et al.   PROGRESS IN NEUROBIOLOGY

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

(2017) Ling Wei et al.   PROGRESS IN NEUROBIOLOGY

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

(2017) Lakshmi Subramanian et al.   Nature Communications

β-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis

(2016) Shannon W. Davis et al.   BMC DEVELOPMENTAL BIOLOGY

Neural Subtype Specification from Human Pluripotent Stem Cells

(2016) Yunlong Tao et al.   Cell Stem Cell

Material Cues as Potent Regulators of Epigenetics and Stem Cell Function

(2016) Spencer W. Crowder et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Combined MSC-Secreted Factors and Neural Stem Cell Transplantation Promote Functional Recovery of PD Rats

(2016) Yuan Yao et al.   CELL TRANSPLANTATION

Generation of bioengineered feather buds on a reconstructed chick skin from dissociated epithelial and mesenchymal cells

(2016) Kentaro Ishida et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

(2016) Christian Lange et al.   EMBO JOURNAL

Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity

(2016) Noelle D. Dwyer et al.   JOURNAL OF NEUROSCIENCE

Studying the pathophysiologic connection between cardiovascular and nervous systems using stem cells

(2016) Volkan Coskun et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson’s disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons

(2016) Can Zhao et al.   NEUROCHEMICAL RESEARCH

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins

(2016) Kerry Marie Goodman et al.   NEURON

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex

(2016) L. Telley et al.   SCIENCE

Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

(2016) Chikafumi Ozone et al.   Nature Communications

Intermittent high oxygen influences the formation of neural retinal tissue from human embryonic stem cells

(2016) Lixiong Gao et al.   Scientific Reports

Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels

(2016) Steve S. Ho et al.   Stem Cells Translational Medicine

Various Cell Populations Within the Mononuclear Fraction of Bone Marrow Contribute to the Beneficial Effects of Autologous Bone Marrow Cell Therapy in a Rodent Stroke Model

(2016) Bing Yang et al.   Translational Stroke Research

Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice

(2016) Yang Yao et al.   Translational Stroke Research

cPKCγ-Modulated Autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mTOR Pathway

(2016) Haiping Wei et al.   Translational Stroke Research

Delayed Docosahexaenoic Acid Treatment Combined with Dietary Supplementation of Omega-3 Fatty Acids Promotes Long-Term Neurovascular Restoration After Ischemic Stroke

(2016) Hongjian Pu et al.   Translational Stroke Research

A Post-stroke Therapeutic Regimen with Omega-3 Polyunsaturated Fatty Acids that Promotes White Matter Integrity and Beneficial Microglial Responses after Cerebral Ischemia

(2016) Xiaoyan Jiang et al.   Translational Stroke Research

Severity-Dependent Long-Term Spatial Learning-Memory Impairment in a Mouse Model of Traumatic Brain Injury

(2016) Chengrui An et al.   Translational Stroke Research

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model

(2016) R. Takagi et al.   Science Advances

Allogeneic Mesenchymal Stem Cell Therapy Outcomes for Three Patients with Spinal Muscular Atrophy Type 1

(2015) Marcello Villanova et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes

(2015) Giacomo Masserdotti et al.   Cell Stem Cell

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Functional differentiation of human pluripotent stem cells on a chip

(2015) Giovanni G Giobbe et al.   NATURE METHODS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Spinal muscular atrophy—recent therapeutic advances for an old challenge

(2015) Irene Faravelli et al.   Nature Reviews Neurology

Engineering Strategies for the Formation of Embryoid Bodies from Human Pluripotent Stem Cells

(2015) Giuseppe Pettinato et al.   STEM CELLS AND DEVELOPMENT

Cerebral cortex assembly: generating and reprogramming projection neuron diversity

(2015) Simona Lodato et al.   TRENDS IN NEUROSCIENCES

Developmental mechanisms channeling cortical evolution

(2015) Barbara L. Finlay et al.   TRENDS IN NEUROSCIENCES

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

(2015) Atsushi Kuwahara et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

(2015) Kenichi Toma et al.   Frontiers in Neuroscience

Diverse subtypes of astrocytes and their development during corticogenesis

(2015) Hidenori Tabata   Frontiers in Neuroscience

Combination Cell Therapy with Mesenchymal Stem Cells and Neural Stem Cells for Brain Stroke in Rats

(2015) Seyed Mojtaba Hosseini et al.   International Journal of Stem Cells

Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes

(2014) Eva L. Feldman et al.   ANNALS OF NEUROLOGY

Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency

(2014) Julie Mathieu et al.   Cell Stem Cell

Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity

(2014) Stewart Anderson et al.   CURRENT OPINION IN NEUROBIOLOGY

Clonal origins of neocortical interneurons

(2014) Khadeejah T Sultan et al.   CURRENT OPINION IN NEUROBIOLOGY

Lineage origins of GABAergic versus glutamatergic neurons in the neocortex

(2014) Oscar Marín et al.   CURRENT OPINION IN NEUROBIOLOGY

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

(2014) Hiroshi Mitsumoto et al.   LANCET NEUROLOGY

Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons

(2014) Gabrielle Pouchelon et al.   NATURE

Mesenchymal stem cell therapy for the treatment of amyotrophic lateral sclerosis: signals for hope?

(2014) Carolina Allers et al.   Regenerative Medicine

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Thinking out of the dish: what to learn about cortical development using pluripotent stem cells

(2014) Jelle van den Ameele et al.   TRENDS IN NEUROSCIENCES

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

Cerebral Organoids in a Dish: Progress and Prospects

(2013) Marina Bershteyn et al.   CELL

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Build-a-Brain

(2013) Stuart M. Chambers et al.   Cell Stem Cell

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

(2013) Yoshiki Sasai   Cell Stem Cell

Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture

(2013) Karl R. Koehler et al.   NATURE

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Integration of GABAergic Interneurons into Cortical Cell Assemblies: Lessons from Embryos and Adults

(2013) Giorgia Bartolini et al.   NEURON

Regenerative Therapies for Central Nervous System Diseases: a Biomaterials Approach

(2013) Roger Y Tam et al.   NEUROPSYCHOPHARMACOLOGY

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling

(2013) Lucy A. Crompton et al.   Stem Cell Research

Functional salivary gland regeneration by transplantation of a bioengineered organ germ

(2013) Miho Ogawa et al.   Nature Communications

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis

(2012) Jiang Fu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

(2012) Koh-ei Toyoshima et al.   Nature Communications

Subregional Specification of Embryonic Stem Cell-Derived Ventral Telencephalic Tissues by Timed and Combinatory Treatment with Extrinsic Signals

(2011) T. Danjo et al.   JOURNAL OF NEUROSCIENCE

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Programming embryonic stem cells to neuronal subtypes

(2010) Mirza Peljto et al.   CURRENT OPINION IN NEUROBIOLOGY

Gingival Fibroblasts as a Promising Source of Induced Pluripotent Stem Cells

(2010) Hiroshi Egusa et al.   PLoS One

Late Origin of Glia-Restricted Progenitors in the Developing Mouse Cerebral Cortex

(2009) Marcos R. Costa et al.   CEREBRAL CORTEX

Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation

(2009) Sarah K. Walsh et al.   EXPERIMENTAL NEUROLOGY

Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

(2009) Solange P. Brown et al.   NATURE

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

(2008) Ashwin Woodhoo et al.   GLIA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules

(2008) Xue-Jun Li et al.   STEM CELLS