Celastrol alleviates metabolic disturbance in high‐fat diet‐induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation

Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

(2020) Wei Hou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Celastrol ameliorates acute liver injury through modulation of PPARα

(2020) Qi Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats

(2020) Weiyue Hu et al.   Diabetes & Metabolism Journal

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

(2019) Tanya Biswas et al.   PROTOPLASMA

Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties

(2019) Luca Gallelli   Drug Design Development and Therapy

Early Celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult Mice

(2019) Stefania Schiavone et al.   MOLECULES

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

(2018) Shao-Ru Chen et al.   Frontiers in Pharmacology

Ginsenoside Rd ameliorates colitis by inducing p62-driven mitophagy-mediated NLRP3 inflammasome inactivation in mice

(2018) Chao Liu et al.   BIOCHEMICAL PHARMACOLOGY

Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites

(2018) Ivana Klopčič et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes

(2016) Tsuyoshi Goto et al.   CYTOKINE

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

(2016) Xiaochao Wei et al.   NATURE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Influencing Factors of Thermogenic Adipose Tissue Activity

(2016) Guoqing Zhang et al.   Frontiers in Physiology

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion

(2015) Daniela Strodthoff et al.   DIABETES

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

TLR-3 is Present in Human Adipocytes, but Its Signalling is Not Required for Obesity-Induced Inflammation in Adipose Tissue In Vivo

(2015) Dov B. Ballak et al.   PLoS One

Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2

(2014) Longhe Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brown adipose tissue and its therapeutic potential

(2014) M. E. Lidell et al.   JOURNAL OF INTERNAL MEDICINE

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation

(2014) Soo Jin Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice

(2012) Linda H. Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Relationship between energy dense diets and white adipose tissue inflammation in metabolic syndrome

(2012) Marià Alemany   NUTRITION RESEARCH

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

The Chemical Biology of Naphthoquinones and Its Environmental Implications

(2011) Yoshito Kumagai et al.   Annual Review of Pharmacology and Toxicology

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

(2011) Jun Bao et al.   RHEUMATOLOGY INTERNATIONAL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Subcutaneous and visceral adipose tissue: structural and functional differences

(2009) M. Mohsen Ibrahim   Obesity Reviews

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY