Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

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Ferroptosis: past, present and future

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Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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Ferroptosis as a target for protection against cardiomyopathy

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A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis

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Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis

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Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

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Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1

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Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

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Recent Progress in Ferroptosis Inducers for Cancer Therapy

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Role of ferroptosis in the process of acute radiation-induced lung injury in mice

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FSP1 is a glutathione-independent ferroptosis suppressor

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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The chemical basis of ferroptosis

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Emerging Strategies of Cancer Therapy Based on Ferroptosis

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Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

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Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

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Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

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FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

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Ferroptosis: A Novel Anti-tumor Action for Cisplatin

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p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

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Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

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P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

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Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Whole cigarette smoke condensates induce ferroptosis in human bronchial epithelial cells

(2018) Eun-Jung Park et al.   TOXICOLOGY LETTERS

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

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Targeting Free Radicals in Oxidative Stress-Related Human Diseases

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Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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The Roles of NRF2 in Modulating Cellular Iron Homeostasis

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Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis

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Autophagy promotes ferroptosis by degradation of ferritin

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CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

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Ferroptosis: process and function

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Ferroptosis is an autophagic cell death process

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Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

(2016) Yue-Qi Wang et al.   Frontiers in Aging Neuroscience

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

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The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

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Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis

(2015) Ting Dong et al.   CHEMBIOCHEM

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

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HSPB1 as a novel regulator of ferroptotic cancer cell death

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Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Advances in Radical-Trapping Antioxidant Chemistry in the 21st Century: A Kinetics and Mechanisms Perspective

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Nox family NADPH oxidases: Molecular mechanisms of activation

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Drugging the p53 pathway: understanding the route to clinical efficacy

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Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

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Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Role of Nrf2 in Oxidative Stress and Toxicity

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The role of iron and reactive oxygen species in cell death

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The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

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Cell signalling by reactive lipid species: new concepts and molecular mechanisms

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Baseline quality of life and performance status as prognostic factors in patients with extensive-stage disease small cell lung cancer treated with pemetrexed plus carboplatin vs. etoposide plus carboplatin

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The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

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MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

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15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells

(2011) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulatory profiling identifies mechanisms of small molecule-induced cell death

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Two to Tango: Regulation of Mammalian Iron Metabolism

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Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Particulate Matter in Cigarette Smoke Alters Iron Homeostasis to Produce a Biological Effect

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Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

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Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

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