Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the  Klotho/FGFR1c Receptor Complex

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Understanding the Physical Interactions in the FGF21/FGFR/β-Klotho Complex: Structural Requirements and Implications in FGF21 Signaling

(2012) Junming Yie et al.   Chemical Biology & Drug Design

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

(2012) Chaofeng Yang et al.   Nutrition & Metabolism

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice

(2012) Murielle M. Véniant et al.   PLoS One

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hormone-like fibroblast growth factors and metabolic regulation

(2011) Yun Chau Long et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid

(2011) Bee K. Tan et al.   DIABETES

Therapeutic utilities of fibroblast growth factor 19

(2011) Xinle Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21

(2011) Jamila Gupte et al.   JOURNAL OF MOLECULAR BIOLOGY

Receptor Antibodies as Novel Therapeutics for Diabetes

(2011) S. Ussar et al.   Science Translational Medicine

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

(2011) A.-L. Wu et al.   Science Translational Medicine

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

(2010) D. A. Sarruf et al.   DIABETES

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 reloaded: challenges of a rapidly growing field

(2010) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

(2009) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 N- and C-termini play different roles in receptor interaction and activation

(2008) Junming Yie et al.   FEBS LETTERS

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY