Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?

FGF19 subfamily members: FGF19 and FGF21

(2019) Katarzyna Dolegowska et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

Skeletal loading score is associated with bone microarchitecture in young adults

(2019) Kristin L. Popp et al.   BONE

Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes

(2019) Eun Shil Hong et al.   BMJ Open Diabetes Research & Care

NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances

(2018) Mazen Noureddin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

(2018) Birgitte Andersen et al.   INTERNATIONAL JOURNAL OF OBESITY

FGF21 acts as a negative regulator of bile acid synthesis

(2018) Michelle M Chen et al.   JOURNAL OF ENDOCRINOLOGY

Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

(2018) Ishan Lakhani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial

(2018) Arun Sanyal et al.   LANCET

Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study

(2018) Edgar D. Charles et al.   Obesity

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

(2017) Shanaka Stanislaus et al.   ENDOCRINOLOGY

FGF1 — a new weapon to control type 2 diabetes mellitus

(2017) Emanuel Gasser et al.   Nature Reviews Endocrinology

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice

(2016) Petra Mulder et al.   Scientific Reports

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway

(2015) Chi Zhang et al.   DIABETOLOGIA

Characterization of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients without cirrhosis

(2015) Bashar Mohamad et al.   Hepatology International

Fibroblast growth factor-21, energy balance and obesity

(2015) Marta Giralt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases

(2015) Fangfang Zhang et al.   MOLECULAR ENDOCRINOLOGY

Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients

(2015) Mette J. Nielsen et al.   PLoS One

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

(2014) Shan Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

(2013) Eric S. Muise et al.   PLoS One

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism