Increased Expression of FGF‐21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

(2018) Birgitte Andersen et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered Bone-Regulating Myokine Expression in Skeletal Muscle of Duchenne Muscular Dystrophy Mouse Models

(2018) Shumin Zhou et al.   MUSCLE & NERVE

Fibroblast Growth Factor 21 Is Associated With Bone Mineral Density, but not With Bone Turnover Markers and Fractures in Chinese Postmenopausal Women

(2018) WeiWei Hu et al.   JOURNAL OF CLINICAL DENSITOMETRY

FGF21 decreases food intake and body weight in obese Göttingen minipigs

(2018) Berit Christoffersen et al.   DIABETES OBESITY & METABOLISM

High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients

(2017) José M. Gallego-Escuredo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bone marrow adipocytes

(2017) Mark C. Horowitz et al.   Adipocyte

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

(2016) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fracture in Duchenne Muscular Dystrophy

(2016) Nadia Perera et al.   JOURNAL OF CHILD NEUROLOGY

A new frontier in FGF21 biology

(2016) Matthew J. Potthoff   Nature Reviews Endocrinology

Dexamethasone in osteogenic medium strongly induces adipocyte differentiation of mouse bone marrow stromal cells and increases osteoblast differentiation

(2015) Olfa Ghali et al.   BMC CELL BIOLOGY

Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa

(2015) Pouneh K. Fazeli et al.   BONE

A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption

(2015) Xunde Wang et al.   Cell Metabolism

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

(2015) Rucha Patel et al.   MOLECULAR ENDOCRINOLOGY

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

(2015) Maitea Guridi et al.   Science Signaling

FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases

(2014) Nobuyuki Itoh   Frontiers in Endocrinology

Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle

(2013) Daniel R. Crooks et al.   HUMAN MOLECULAR GENETICS

Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression

(2013) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?

(2013) P. Lee et al.   OSTEOPOROSIS INTERNATIONAL

Platelet-Rich Plasma Promotes the Proliferation of Human Muscle Derived Progenitor Cells and Maintains Their Stemness

(2013) Hongshuai Li et al.   PLoS One

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

(2012) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities

(2012) Christian Isaac et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers

(2011) Birgitte Andersen et al.   CLINICAL ENDOCRINOLOGY

Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans

(2011) Anna Rufo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

(2009) Pernille Hojman et al.   DIABETES

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS