MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

(2013) Sung-E Choi et al.   AGING CELL

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

(2013) Hang Yin et al.   Cell Metabolism

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

(2013) Claudio J. Villanueva et al.   Cell Metabolism

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

(2013) M. K. Montgomery et al.   DIABETOLOGIA

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Regulation of SIRT1 by MicroRNAs

(2013) Sung-E Choi et al.   MOLECULES AND CELLS

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

(2013) Yong Chen et al.   Nature Communications

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway

(2012) Julieta Díaz-Delfín et al.   ENDOCRINOLOGY

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

MyomiR-133 regulates brown fat differentiation through Prdm16

(2012) Mirko Trajkovski et al.   NATURE CELL BIOLOGY

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 Takes a Fat Bite

(2012) C. Canto et al.   SCIENCE

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

(2011) Clarence Hale et al.   ENDOCRINOLOGY

Brown Adipose Tissue in Morbidly Obese Subjects

(2011) Guy H. E. J. Vijgen et al.   PLoS One

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

(2010) Andrea Frontini et al.   Cell Metabolism

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

(2010) f. M. Fisher et al.   DIABETES

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition

(2010) Jiyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation

(2010) Francisco J. Ortega et al.   PLoS One

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

(2008) Jean-Pierre Després et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

(2008) M. Mraz et al.   CLINICAL ENDOCRINOLOGY

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

(2008) S. Kajimura et al.   GENES & DEVELOPMENT