Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

(2018) Angelos Papaspyropoulos et al.   Nature Communications

Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ

(2018) Paraskevi Xekouki et al.   ENDOCRINE-RELATED CANCER

Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing

(2018) Leah B. Nantie et al.   DEVELOPMENT

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

(2018) Alfonso Lavado et al.   DEVELOPMENTAL CELL

Temozolomide treatment can improve overall survival in aggressive pituitary tumors and pituitary carcinomas

(2017) Hélène Lasolle et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

(2017) Jose Mario Gonzalez-Meljem et al.   Nature Communications

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

(2016) Tito Panciera et al.   Cell Stem Cell

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

(2016) Zhi-Yan Han et al.   Nature Communications

Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development

(2016) Emily J. Lodge et al.   Frontiers in Physiology

A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth

(2015) Chuwen Lin et al.   DEVELOPMENTAL BIOLOGY

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Non-metastatic squamous cell carcinoma within a Rathke’s cleft cyst

(2015) Brian T. O’Neill et al.   Pituitary

Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

(2015) Upal Basu-Roy et al.   Nature Communications

Notch-Dependent Pituitary SOX2 + Stem Cells Exhibit a Timed Functional Extinction in Regulation of the Postnatal Gland

(2015) Xiaoyan Zhu et al.   Stem Cell Reports

Management of aggressive pituitary adenomas and pituitary carcinomas

(2014) Anthony Heaney   JOURNAL OF NEURO-ONCOLOGY

Notch Signaling in Postnatal Pituitary Expansion: Proliferation, Progenitors, and Cell Specification

(2014) Leah B. Nantie et al.   MOLECULAR ENDOCRINOLOGY

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Sox2+ Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential

(2013) Cynthia Lilian Andoniadou et al.   Cell Stem Cell

Mobilized Adult Pituitary Stem Cells Contribute to Endocrine Regeneration in Response to Physiological Demand

(2013) Karine Rizzoti et al.   Cell Stem Cell

Changes in pituitary function with ageing and implications for patient care

(2013) Johannes D. Veldhuis   Nature Reviews Endocrinology

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma

(2012) Cynthia L. Andoniadou et al.   ACTA NEUROPATHOLOGICA

Pituitary Phenotypes of Mice Lacking the Notch Signalling Ligand Delta-Like 1 Homologue

(2012) L. Y. M. Cheung et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Normal Hematopoietic Stem Cell Function in Mice with Enforced Expression of the Hippo Signaling Effector YAP1

(2012) Lina Jansson et al.   PLoS One

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Management of pituitary tumors in pregnancy

(2011) Marcello D. Bronstein et al.   Nature Reviews Endocrinology

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development

(2008) Carles Gaston-Massuet et al.   DEVELOPMENTAL BIOLOGY

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism

(2008) E. Sajedi et al.   Disease Models & Mechanisms

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT