Anti-Apoptotic Effects of Carotenoids in Neurodegeneration

Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia

(2020) Wei-Ning Lin et al.   Marine Drugs

Free Radical Mediated Oxidative Degradation of Carotenes and Xanthophylls

(2020) Raphael C. Mordi et al.   MOLECULES

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

(2020) Yuting Ke et al.   Frontiers in Pharmacology

Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats

(2020) EM El Morsy et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

miR‐30b protects nigrostriatal dopaminergic neurons from MPP(+)‐induced neurotoxicity via SNCA

(2020) Yu‐fei Shen et al.   Brain and Behavior

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

(2020) Rachel E. James et al.   Acta Neuropathologica Communications

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration

(2020) Nelli Mnatsakanyan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Long-term lutein administration attenuates retinal inflammation and functional deficits in early diabetic retinopathy using the Ins2Akita/+ mice

(2020) Wei Wang et al.   BMJ Open Diabetes Research & Care

Dietary Antioxidants and Parkinson’s Disease

(2020) Han-A Park et al.   Antioxidants

Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain

(2020) Fu Li et al.   PHYSIOLOGY & BEHAVIOR

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats

(2019) Xiaolin Deng et al.   Frontiers in Cellular Neuroscience

A review for the pharmacological effect of lycopene in central nervous system disorders

(2019) Dongjian Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

(2019) Rongmin Chen et al.   Cell Death & Disease

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease

(2019) Sundas Hira et al.   Biomolecules

Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis

(2019) Johant Lakey-Beitia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons

(2019) Han-A Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

Dietary astaxanthin can accumulate in the brain of rats

(2018) Yuki Manabe et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification

(2018) Zoltan Simandi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain

(2018) Xi Jiang et al.   NEUROSCIENCE LETTERS

Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases

(2018) Kyoung Sang Cho et al.   Oxidative Medicine and Cellular Longevity

BDNF signaling: Harnessing stress to battle mood disorder

(2018) Pawel Licznerski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice

(2018) Minzhong Yu et al.   Nutrients

Lutein Suppresses Oxidative Stress and Inflammation by Nrf2 Activation in an Osteoporosis Rat Model

(2018) Hongtao Li et al.   MEDICAL SCIENCE MONITOR

Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling

(2018) Lixun Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

(2018) YiLong Dong et al.   BMC NEUROSCIENCE

The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage

(2018) Cuiqin Huang et al.   Oxidative Medicine and Cellular Longevity

Retinoic acid receptor α expression exerts an anti‑apoptosis effect on PC12 cells following oxygen‑glucose deprivation

(2018) Wanliang Dong et al.   Experimental and Therapeutic Medicine

Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut–liver–brain axis

(2018) Jia Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Nutritional Regulators of Bcl-xL in the Brain

(2018) Han-A Park et al.   MOLECULES

Determination of fucoxanthinol in rat plasma by liquid chromatography-tandem mass spectrometry

(2018) Yiping Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

(2017) Beita Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells

(2017) Katja Frede et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fucoxanthin Inhibits β-Amyloid Assembly and Attenuates β-Amyloid Oligomer-Induced Cognitive Impairments

(2017) Siying Xiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study

(2017) J. Atilio Canas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lutein protects against severe traumatic brain injury through anti-inflammation and antioxidative effects via ICAM-1/Nrf-2

(2017) Dianhui Tan et al.   Molecular Medicine Reports

ΔN-Bcl-xL, a therapeutic target for neuroprotection

(2017) Han-A Park et al.   Neural Regeneration Research

Inhibition of Na + -K + -2Cl − cotransporter attenuates blood-brain-barrier disruption in a mouse model of traumatic brain injury

(2017) Jun Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment

(2017) Jingwen Qiao et al.   NEUROSCIENCE LETTERS

Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

(2017) Jiajia Lin et al.   Oxidative Medicine and Cellular Longevity

Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants

(2017) Jan Rehker et al.   PLoS One

Lutein accumulates in subcellular membranes of brain regions in adult rhesus macaques: Relationship to DHA oxidation products

(2017) Emily S. Mohn et al.   PLoS One

Carotenoids Database: structures, chemical fingerprints and distribution among organisms

(2017) Junko Yabuzaki   Database-The Journal of Biological Databases and Curation

Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells

(2017) et al.   Nutrients

Antagonistic effects of lycopene on cadmium-induced hippocampal dysfunctions in autophagy, calcium homeostatis and redox

(2017) Fenghua Zhang et al.   Oncotarget

Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial

(2017) Billy R. Hammond et al.   Frontiers in Aging Neuroscience

Fucoxanthin prevents H2O2-induced neuronal apoptosis via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway

(2017) Jie Yu et al.   Food & Nutrition Research

The Effects of Lycopene and Insulin on Histological Changes and the Expression Level of Bcl-2 Family Genes in the Hippocampus of Streptozotocin-Induced Diabetic Rats

(2017) Masoume Soleymaninejad et al.   Journal of Diabetes Research

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

Beta-carotene as a novel therapy for the treatment of “Autistic like behavior” in animal models of Autism

(2017) Yosefa Avraham et al.   BEHAVIOURAL BRAIN RESEARCH

Differential Roles of Carotenes and Xanthophylls in Photosystem I Photoprotection

(2016) Stefano Cazzaniga et al.   BIOCHEMISTRY

ProCarDB: a database of bacterial carotenoids

(2016) L. N. U. Nupur et al.   BMC MICROBIOLOGY

Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice

(2016) Xi Jiang et al.   BRAIN RESEARCH

Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation

(2016) Fang Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Improvement of depressive behavior by Sweetme Sweet Pumpkin™ and its active compound, β-carotene

(2016) Na-Rae Kim et al.   LIFE SCIENCES

Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro

(2016) Jiajia Lin et al.   Marine Drugs

Lycopene protects human SH-SY5Y neuroblastoma cells against hydrogen peroxide-induced death via inhibition of oxidative stress and mitochondria-associated apoptotic pathways

(2016) CHUNSHENG FENG et al.   Molecular Medicine Reports

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

(2016) Mingyue Qu et al.   NEUROCHEMICAL RESEARCH

Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells

(2016) Frederic K. C. Fung et al.   PLoS One

Lutein acts via multiple antioxidant pathways in the photo-stressed retina

(2016) Mamoru Kamoshita et al.   Scientific Reports

Bcl-xL Is Necessary for Neurite Outgrowth in Hippocampal Neurons

(2015) Han-A Park et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina

(2015) Chanjuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Programmed Cell Death in Neurodevelopment

(2015) Yoshifumi Yamaguchi et al.   DEVELOPMENTAL CELL

Hypoxia promotes apoptosis of neuronal cells through hypoxia-inducible factor-1α-microRNA-204-B-cell lymphoma-2 pathway

(2015) Xiuwen Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The BH4 Domain of Anti-apoptotic Bcl-XL, but Not That of the Related Bcl-2, Limits the Voltage-dependent Anion Channel 1 (VDAC1)-mediated Transfer of Pro-apoptotic Ca2+Signals to Mitochondria

(2015) Giovanni Monaco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simultaneous Determination of Fucoxanthin and Its Deacetylated Metabolite Fucoxanthinol in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry

(2015) Yiping Zhang et al.   Marine Drugs

Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress

(2015) Jagatheesan Nataraj et al.   NUTRITIONAL NEUROSCIENCE

Programmed cell death during neuronal development: the sympathetic neuron model

(2014) M Kristiansen et al.   CELL DEATH AND DIFFERENTIATION

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

(2014) Atish Prakash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia

(2014) Ya-Xuan Sun et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

(2014) Ranga Ambati et al.   Marine Drugs

Melatonin reduces traumatic brain injury-induced oxidative stress in the cerebral cortex and blood of rats

(2014) Mustafa Nazıroğlu et al.   Neural Regeneration Research

Mitochondrial membrane protein Bcl-xL, a regulator of adult neuronal growth and synaptic plasticity: multiple functions beyond apoptosis

(2014) ElizabethA Jonas et al.   Neural Regeneration Research

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Potential Role of Carotenoids as Antioxidants in Human Health and Disease

(2014) Joanna Fiedor et al.   Nutrients

Supplementation of Adult Rats with Moderate Amounts of β-Carotene Modulates the Redox Status in Plasma without Exerting Pro-Oxidant Effects in the Brain: A Safer Alternative to Food Fortification with Vitamin A?

(2014) Carlos Schnorr et al.   Nutrients

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

Effective Inhibition of Skin Cancer, Tyrosinase, and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from the Green Alga Haematococcus pluvialis

(2013) Ambati Ranga Rao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta-carotene, and canthaxanthin

(2013) Chi-Sen Chang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways

(2013) Hsiao-Yun Lin et al.   NEUROBIOLOGY OF AGING

A Potential Commercial Source of Fucoxanthin Extracted from the Microalga Phaeodactylum tricornutum

(2012) Sang Min Kim et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils

(2012) Marcelo Paes Barros et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance

(2012) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death

(2012) Dimitry Ofengeim et al.   NATURE NEUROSCIENCE

Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet

(2012) Jung Eun Kim et al.   Nutrition Research and Practice

Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates

(2012) Rohini Vishwanathan et al.   NUTRITIONAL NEUROSCIENCE

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

(2012) W Kudo et al.   Cell Death & Disease

The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons

(2011) Rosie Hughes et al.   BMC NEUROSCIENCE

Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin

(2011) Chia-Chia Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke

(2011) Suk-Yee Li et al.   NEUROBIOLOGY OF DISEASE

Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway

(2011) Mingyue Qu et al.   NEUROCHEMISTRY INTERNATIONAL

Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

(2011) Hongyi Qi et al.   NEUROPHARMACOLOGY

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

(2011) Han-A Park et al.   STROKE

Molecular Factors Controlling Photosynthetic Light Harvesting by Carotenoids

(2010) Tomáš Polívka et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effect of Thermal Processing on the Degradation, Isomerization, and Bioaccessibility of Lycopene in Tomato Pulp

(2010) Ines Colle et al.   JOURNAL OF FOOD SCIENCE

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

(2010) Jean Park et al.   Nutrition & Metabolism

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

(2010) José Monroy-Ruiz et al.   PHARMACOLOGICAL RESEARCH

An Update on the Health Effects of Tomato Lycopene

(2010) Erica N. Story et al.   Annual Review of Food Science and Technology

The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice

(2009) Takashi Hashimoto et al.   BRITISH JOURNAL OF NUTRITION

Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk

(2009) V. Fradet et al.   CLINICAL CANCER RESEARCH

Astaxanthin reduces ischemic brain injury in adult rats

(2009) Hui Shen et al.   FASEB JOURNAL

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Tomato Lycopene Extract Prevents Lipopolysaccharide-Induced NF-κB Signaling but Worsens Dextran Sulfate Sodium-Induced Colitis in NF-κBEGFP Mice

(2009) Young-Eun Joo et al.   PLoS One

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Lycopene inhibits TNF-α-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion

(2008) Chi-Feng Hung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

(2008) T. Miyawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH