Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

Extensive subpial cortical demyelination is specific to multiple sclerosis

(2020) Andreas Junker et al.   BRAIN PATHOLOGY

Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis

(2019) Roberta Magliozzi et al.   Journal of Neuroinflammation

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

(2018) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Meningeal inflammation and cortical demyelination in acute multiple sclerosis

(2018) Ryan J. Bevan et al.   ANNALS OF NEUROLOGY

Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats

(2017) Muammer Üçal et al.   EXPERIMENTAL NEUROLOGY

Neuronal loss, demyelination and volume change in the multiple sclerosis neocortex

(2017) D. Carassiti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

(2016) Lukas Haider et al.   BRAIN

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

(2016) Lewis M. Watkins et al.   Journal of Neuroinflammation

Exploring the origins of grey matter damage in multiple sclerosis

(2015) Massimiliano Calabrese et al.   NATURE REVIEWS NEUROSCIENCE

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

(2014) Malika Bsibsi et al.   ACTA NEUROPATHOLOGICA

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

(2013) Christopher Gardner et al.   BRAIN

Disease-specific molecular events in cortical multiple sclerosis lesions

(2013) Marie Therese Fischer et al.   BRAIN

Assessment of Paclitaxel Induced Sensory Polyneuropathy with “Catwalk” Automated Gait Analysis in Mice

(2013) Petra Huehnchen et al.   PLoS One

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

(2013) Nemat Khan et al.   INFLAMMOPHARMACOLOGY

Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study

(2012) Pascal F. Durrenberger et al.   ACTA NEUROPATHOLOGICA

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis

(2012) Sung R. Choi et al.   BRAIN

The neuropathological basis of clinical progression in multiple sclerosis

(2011) Richard Reynolds et al.   ACTA NEUROPATHOLOGICA

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications

(2011) Christine Stadelmann   CURRENT OPINION IN NEUROLOGY

Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein

(2011) D C J Carpentier et al.   GENE THERAPY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways

(2010) Caterina Veroni et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

A Comprehensive Analysis of Gait Impairment after Experimental Stroke and the Therapeutic Effect of Environmental Enrichment in Rats

(2008) Yonggang Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM