THE IMS PARADOX: A PERSPECTIVE ON STRUCTURAL ION MOBILITY‐MASS SPECTROMETRY

Melting of Hemoglobin in Native Solutions as measured by IMS-MS

(2020) Daniel W. Woodall et al.   ANALYTICAL CHEMISTRY

Collision Cross Sections of Charge-Reduced Proteins and Protein Complexes: A Database for Collision Cross Section Calibration

(2020) Alyssa Q. Stiving et al.   ANALYTICAL CHEMISTRY

Structural Analysis of the Effect of a Dual-FLAG Tag on Transthyretin

(2020) Mehdi Shirzadeh et al.   BIOCHEMISTRY

Tracking the Structural Evolution of 4-Aminobenzoic Acid in the Transition from Solution to the Gas Phase

(2020) Michael J. Hebert et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rapid Determination of Activation Energies for Gas-Phase Protein Unfolding and Dissociation in a Q-IM-ToF Mass Spectrometer

(2020) Micah T. Donor et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Comparative Structural Analysis of 20S Proteasome Ortholog Protein Complexes by Native Mass Spectrometry

(2020) Shay Vimer et al.   ACS Central Science

Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways

(2019) Mehdi Shirzadeh et al.   ANALYTICAL CHEMISTRY

Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

(2019) Yang Liu et al.   Nature Communications

Hydration of Guanidinium Ions: An Experimental Search for Like-Charged Ion Pairs

(2019) Michael J. Hebert et al.   Journal of Physical Chemistry Letters

Surface-Induced Dissociation of Noncovalent Protein Complexes in an Extended Mass Range Orbitrap Mass Spectrometer

(2019) Zachary L. VanAernum et al.   ANALYTICAL CHEMISTRY

CIUSuite 2: Next-Generation Software for the Analysis of Gas-Phase Protein Unfolding Data

(2019) Daniel A. Polasky et al.   ANALYTICAL CHEMISTRY

A Cyclic Ion Mobility – Mass Spectrometry System

(2019) Kevin Giles et al.   ANALYTICAL CHEMISTRY

Substance P in the Gas Phase: Conformational Changes and Dissociations Induced by Collisional Activation in a Drift Tube

(2019) Christopher R. Conant et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A strategy for the identification of protein architectures directly from ion mobility mass spectrometry data reveals stabilizing subunit interactions in light harvesting complexes

(2019) Margit Kaldmäe et al.   PROTEIN SCIENCE

Computational insights into compaction of gas-phase protein and protein complex ions in native ion mobility-mass spectrometry

(2019) Amber D. Rolland et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry

(2019) Zahra Moghadamchargari et al.   BIOCHEMISTRY

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Native IM-Orbitrap MS: Resolving what was hidden

(2019) Michael L. Poltash et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Solution thermochemistry of concanavalin A tetramer conformers measured by variable-temperature ESI-IMS-MS

(2019) Tarick J. El-Baba et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Advances in the treatment of hereditary transthyretin amyloidosis: A review

(2019) Morie A. Gertz et al.   Brain and Behavior

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics

(2019) Luca Fornelli et al.   MOLECULAR & CELLULAR PROTEOMICS

Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry

(2018) Guanbo Wang et al.   ANALYST

The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies

(2018) Yuwei Tian et al.   ANALYST

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

(2018) Kyle L. Fort et al.   ANALYST

High-Resolution Hydroxyl Radical Protein Footprinting: Biophysics Tool for Drug Discovery

(2018) Janna Kiselar et al.   Annual Review of Biophysics

Measuring Entropy in Molecular Recognition by Proteins

(2018) A. Joshua Wand et al.   Annual Review of Biophysics

Melting proteins confined in nanodroplets with 10.6 μm light provides clues about early steps of denaturation

(2018) Tarick J. El-Baba et al.   CHEMICAL COMMUNICATIONS

Collision induced unfolding of isolated proteins in the gas phase: past, present, and future

(2018) Sugyan M Dixit et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

(2018) Joseph Gault et al.   Journal of Physical Chemistry Letters

Multiple Pathways in Capsid Assembly

(2018) Corinne A. Lutomski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conformationally regulated peptide bond cleavage in bradykinin

(2018) Daniel R. Fuller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allostery revealed within lipid binding events to membrane proteins

(2018) John W. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-assembly of toroidal proteins explored using native mass spectrometry

(2018) N. Amy Yewdall et al.   Chemical Science

Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry

(2018) Michael L. Poltash et al.   ANALYTICAL CHEMISTRY

Collision-Induced Unfolding of Partially Metalated Metallothionein-2A: Tracking Unfolding Reactions of Gas Phase Ions

(2018) Shiyu Dong et al.   ANALYTICAL CHEMISTRY

Thermal Denaturation of DNA G-Quadruplexes and Their Complexes with Ligands: Thermodynamic Analysis of the Multiple States Revealed by Mass Spectrometry

(2018) Adrien Marchand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

(2018) Alyssa Q. Stiving et al.   ANALYTICAL CHEMISTRY

Melting Proteins: Evidence for Multiple Stable Structures upon Thermal Denaturation of Native Ubiquitin from Ion Mobility Spectrometry-Mass Spectrometry Measurements

(2017) Tarick J. El-Baba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ions from Solution to the Gas Phase: A Molecular Dynamics Simulation of the Structural Evolution of Substance P during Desolvation of Charged Nanodroplets Generated by Electrospray Ionization

(2017) Doyong Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of a TW-SLIM Module for Dual Polarity Confinement, Transport, and Reactions

(2017) Sandilya V. B. Garimella et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

What factors determine the stability of a weak protein–protein interaction in a charged aqueous droplet?

(2017) Myong In Oh et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

GroEL actively stimulates folding of the endogenous substrate protein PepQ

(2017) Jeremy Weaver et al.   Nature Communications

Cryogenic Ion Mobility-Mass Spectrometry: Tracking Ion Structure from Solution to the Gas Phase

(2016) Kelly A. Servage et al.   ACCOUNTS OF CHEMICAL RESEARCH

Increasing Ubiquitin Ion Resistance to Unfolding in the Gas Phase Using Chloride Adduction: Preserving More “Native-Like” Conformations Despite Collisional Activation

(2016) Nicole D. Wagner et al.   ANALYTICAL CHEMISTRY

Augmenting Ion Trap Mass Spectrometers Using a Frequency Modulated Drift Tube Ion Mobility Spectrometer

(2016) Kelsey A. Morrison et al.   ANALYTICAL CHEMISTRY

Long-Lived Intermediates in a Cooperative Two-State Folding Transition

(2016) Tarick J. El-Baba et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Defining Noncovalent Ubiquitin Homodimer Interfacial Interactions through Comparisons with Covalently Linked Diubiquitin

(2016) Nicole D. Wagner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Determining Membrane Protein–Lipid Binding Thermodynamics Using Native Mass Spectrometry

(2016) Xiao Cong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Wet” Versus “Dry” Folding of Polyproline

(2016) Liuqing Shi et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Radio-Frequency (rf) Confinement in Ion Mobility Spectrometry: Apparent Mobilities and Effective Temperatures

(2016) Samuel J. Allen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

An infrared spectroscopy approach to follow β-sheet formation in peptide amyloid assemblies

(2016) Jongcheol Seo et al.   Nature Chemistry

Effects of charge states, charge sites and side chain interactions on conformational preferences of a series of model peptide ions

(2015) Chunying Xiao et al.   ANALYST

Illustration of SID-IM-SID (surface-induced dissociation-ion mobility-SID) mass spectrometry: homo and hetero model protein complexes

(2015) Royston S. Quintyn et al.   ANALYST

Surface-Induced Dissociation Mass Spectra as a Tool for Distinguishing Different Structural Forms of Gas-Phase Multimeric Protein Complexes

(2015) Royston S. Quintyn et al.   ANALYTICAL CHEMISTRY

Reaction of Human Cd7metallothionein and N-Ethylmaleimide: Kinetic and Structural Insights from Electrospray Ionization Mass Spectrometry

(2015) Shu-Hua Chen et al.   BIOCHEMISTRY

Surface induced dissociation yields substructure of Methanosarcina thermophila 20S proteasome complexes

(2015) Xin Ma et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

From Solution to Gas Phase: The Implications of Intramolecular Interactions on the Evaporative Dynamics of Substance P During Electrospray Ionization

(2015) Kelly A. Servage et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Water-Mediated Dimerization of Ubiquitin Ions Captured by Cryogenic Ion Mobility-Mass Spectrometry

(2015) Kelly A. Servage et al.   Journal of Physical Chemistry Letters

Unfolding of Hydrated Alkyl Diammonium Cations Revealed by Cryogenic Ion Mobility-Mass Spectrometry

(2015) Kelly A. Servage et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Configurationally-Coupled Protonation of Polyproline-7

(2015) Liuqing Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility-Mass Spectrometry Reveals the Energetics of Intermediates that Guide Polyproline Folding

(2015) Liuqing Shi et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

How Closely Related Are Conformations of Protein Ions Sampled by IM-MS to Native Solution Structures?

(2015) Shu-Hua Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometric methods to analyze the structural organization of macromolecular complexes

(2015) Khadijeh Rajabi et al.   METHODS

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Refining the Structural Model of a Heterohexameric Protein Complex: Surface Induced Dissociation and Ion Mobility Provide Key Connectivity and Topology Information

(2015) Yang Song et al.   ACS Central Science

Surface Induced Dissociation: Dissecting Noncovalent Protein Complexes in the Gas phase

(2014) Mowei Zhou et al.   ACCOUNTS OF CHEMICAL RESEARCH

Quantification of Quaternary Structure Stability in Aggregation-Prone Proteins under Physiological Conditions: The Transthyretin Case

(2014) Lei Z. Robinson et al.   BIOCHEMISTRY

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

(2014) Irit Rappley et al.   BIOCHEMISTRY

Comparative study of hydration shell dynamics around a hyperactive antifreeze protein and around ubiquitin

(2014) Elise Duboué-Dijon et al.   JOURNAL OF CHEMICAL PHYSICS

From Solution to the Gas Phase: Factors That Influence Kinetic Trapping of Substance P in the Gas Phase

(2014) Kyle L. Fort et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Hydrodynamic Comparison of Solution and Gas Phase Proteins and Their Complexes

(2014) Dominic Hewitt et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Photodissociation of Conformer-Selected Ubiquitin Ions Reveals Site-Specific Cis/Trans Isomerization of Proline Peptide Bonds

(2014) Stephan Warnke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterizing Intermediates Along the Transition from Polyproline I to Polyproline II Using Ion Mobility Spectrometry-Mass Spectrometry

(2014) Liuqing Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Induced Conformational Changes of Human Metallothionein-2A: A Combined Theoretical and Experimental Study of Metal-Free and Partially Metalated Intermediates

(2014) Shu-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Combining Chemical Labeling, Bottom-Up and Top-Down Ion-Mobility Mass Spectrometry To Identify Metal-Binding Sites of Partially Metalated Metallothionein

(2013) Shu-Hua Chen et al.   ANALYTICAL CHEMISTRY

Principles of electron capture and transfer dissociation mass spectrometry applied to peptide and protein structure analysis

(2013) Konstantin O. Zhurov et al.   CHEMICAL SOCIETY REVIEWS

Cryogenic Ion Mobility-Mass Spectrometry Captures Hydrated Ions Produced During Electrospray Ionization

(2013) Joshua A. Silveira et al.   JOURNAL OF PHYSICAL CHEMISTRY A

From Solution to the Gas Phase: Stepwise Dehydration and Kinetic Trapping of Substance P Reveals the Origin of Peptide Conformations

(2013) Joshua A. Silveira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Damping Factor Links Periodic Focusing and Uniform Field Ion Mobility for Accurate Determination of Collision Cross Sections

(2012) Joshua A. Silveira et al.   ANALYTICAL CHEMISTRY

Ion Mobility-Mass Spectrometry (IM-MS) for Top-Down Proteomics: Increased Dynamic Range Affords Increased Sequence Coverage

(2012) Nathanael F. Zinnel et al.   ANALYTICAL CHEMISTRY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

(2012) L.A. Woods et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Conformational Distribution of Bradykinin [bk + 2 H]2+ Revealed by Cold Ion Spectroscopy Coupled with FAIMS

(2012) Georgios Papadopoulos et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Interplay of Intra- and Intermolecular H-Bonding in a Progressively Solvated Macrocyclic Peptide

(2012) N. S. Nagornova et al.   SCIENCE

Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils

(2011) Artur F. Castro-Rodrigues et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Noncovalent Dimerization of Ubiquitin

(2011) Zhu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gas-phase ion dynamics in a periodic-focusing DC ion guide (Part II): Discrete transport modes

(2011) Chaminda M. Gamage et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Like-Charge Guanidinium Pairing from Molecular Dynamics and Ab Initio Calculations

(2011) Mario Vazdar et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Mapping the Hydration Dynamics of Ubiquitin

(2011) Nathaniel V. Nucci et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Number of Solution States of Bradykinin from Ion Mobility and Mass Spectrometry Measurements

(2011) Nicholas A. Pierson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mass-Selective Variable-Temperature Drift Tube Ion Mobility-Mass Spectrometer for Temperature Dependent Ion Mobility Studies

(2011) Jody C. May et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology

(2010) Matthew F. Bush et al.   ANALYTICAL CHEMISTRY

Gas-phase ion dynamics in a periodic-focusing DC ion guide

(2010) Joshua A. Silveira et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Increased ion transmission in IMS: A high resolution, periodic-focusing DC ion guide ion mobility spectrometer

(2010) Ryan C. Blase et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Novel Zn2+-binding Sites in Human Transthyretin

(2010) Leonardo de C. Palmieri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interfacial Water at Protein Surfaces: Wide-Line NMR and DSC Characterization of Hydration in Ubiquitin Solutions

(2009) Kálmán Tompa et al.   BIOPHYSICAL JOURNAL

Hydration of biomolecules

(2009) Thomas Wyttenbach et al.   CHEMICAL PHYSICS LETTERS

Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes

(2009) Suk-Joon Hyung et al.   CHEMISTRY & BIOLOGY

Gas-phase IR spectra of intact α-helical coiled coil protein complexes

(2009) Kevin Pagel et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

On the Structure Elucidation Using Ion Mobility Spectrometry and Molecular Dynamics

(2009) F. A. Fernandez-Lima et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Does the Dynamic Stokes Shift Report on Slow Protein Hydration Dynamics?

(2009) Bertil Halle et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Factors That Influence Helical Preferences for Singly Charged Gas-Phase Peptide Ions: The Effects of Multiple Potential Charge-Carrying Sites

(2009) Janel R. McLean et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Chaperonin Complexes Monitored by Ion Mobility Mass Spectrometry

(2009) Esther van Duijn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamics at the Protein-Water Interface from 17O Spin Relaxation in Deeply Supercooled Solutions

(2008) Carlos Mattea et al.   BIOPHYSICAL JOURNAL

Trapping the Monomer of a Non-amyloidogenic Variant of Transthyretin

(2008) Fernando L. Palhano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collisional activation of protein complexes: Picking up the pieces

(2008) Justin L. P. Benesch   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Stepwise evolution of protein native structure with electrospray into the gas phase, 10-12 to 102 s

(2008) K. Breuker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA