The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies
Authors
Keywords
-
Journal
ANALYST
Volume 143, Issue 11, Pages 2459-2468
Publisher
Royal Society of Chemistry (RSC)
Online
2018-05-01
DOI
10.1039/c8an00295a
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Correlating the Effects of Antimicrobial Preservatives on Conformational Stability, Aggregation Propensity, and Backbone Flexibility of an IgG1 mAb
- (2017) Jayant Arora et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer
- (2017) Luca Fornelli et al. Journal of Proteomics
- Characterization of Therapeutic Monoclonal Antibodies at the Subunit-Level using Middle-Down 193 nm Ultraviolet Photodissociation
- (2016) Victoria C. Cotham et al. ANALYTICAL CHEMISTRY
- Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry
- (2016) Damian Houde et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Antibodies to watch in 2017
- (2016) Janice M. Reichert mAbs
- Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
- (2016) Claire L. Dobson et al. Scientific Reports
- Characterization of Drug-Product-Related Impurities and Variants of a Therapeutic Monoclonal Antibody by Higher Energy C-Trap Dissociation Mass Spectrometry
- (2015) Deyun Wang et al. ANALYTICAL CHEMISTRY
- Collision Induced Unfolding of Intact Antibodies: Rapid Characterization of Disulfide Bonding Patterns, Glycosylation, and Structures
- (2015) Yuwei Tian et al. ANALYTICAL CHEMISTRY
- CIUSuite: A Quantitative Analysis Package for Collision Induced Unfolding Measurements of Gas-Phase Protein Ions
- (2015) Joseph D. Eschweiler et al. ANALYTICAL CHEMISTRY
- Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector
- (2015) Andrey Dyachenko et al. ANALYTICAL CHEMISTRY
- Ion Activation Methods for Peptides and Proteins
- (2015) Jennifer S. Brodbelt ANALYTICAL CHEMISTRY
- Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability
- (2015) Matthew J. Edgeworth et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Analytical Aspects of Hydrogen Exchange Mass Spectrometry
- (2015) John R. Engen et al. Annual Review of Analytical Chemistry
- Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies
- (2015) Alain Beck et al. JOURNAL OF MASS SPECTROMETRY
- Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody
- (2015) Jayant Arora et al. mAbs
- Identification of carbohydrate anomers using ion mobility–mass spectrometry
- (2015) J. Hofmann et al. NATURE
- Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate
- (2015) Julien Marcoux et al. PROTEIN SCIENCE
- Conformation and Dynamics of Interchain Cysteine-Linked Antibody-Drug Conjugates as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2014) Lucy Yan Pan et al. ANALYTICAL CHEMISTRY
- Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling
- (2014) Aming Zhang et al. ANALYTICAL CHEMISTRY
- Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014
- (2014) Gregory F. Pirrone et al. ANALYTICAL CHEMISTRY
- Hybridizing Ultraviolet Photodissociation with Electron Transfer Dissociation for Intact Protein Characterization
- (2014) Joe R. Cannon et al. ANALYTICAL CHEMISTRY
- Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry
- (2014) Luca Fornelli et al. ANALYTICAL CHEMISTRY
- Innovative Native MS Methodologies for Antibody Drug Conjugate Characterization: High Resolution Native MS and IM-MS for Average DAR and DAR Distribution Assessment
- (2014) François Debaene et al. ANALYTICAL CHEMISTRY
- Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling
- (2014) Kamila J. Pacholarz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy
- (2014) Ravi V. J. Chari et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Collisional and Coulombic Unfolding of Gas-Phase Proteins: High Correlation to Their Domain Structures in Solution
- (2014) Yueyang Zhong et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Top Down proteomics: Facts and perspectives
- (2014) Adam D. Catherman et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Membrane proteins bind lipids selectively to modulate their structure and function
- (2014) Arthur Laganowsky et al. NATURE
- Biopharmaceutical benchmarks 2014
- (2014) Gary Walsh NATURE BIOTECHNOLOGY
- The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
- (2014) Francesco Lanucara et al. Nature Chemistry
- Carbohydrate Structure Characterization by Tandem Ion Mobility Mass Spectrometry (IMMS)2
- (2013) Hongli Li et al. ANALYTICAL CHEMISTRY
- From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry
- (2013) Mikhail E. Belov et al. ANALYTICAL CHEMISTRY
- Activation State-Selective Kinase Inhibitor Assay Based on Ion Mobility-Mass Spectrometry
- (2013) Jessica N. Rabuck et al. ANALYTICAL CHEMISTRY
- Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry
- (2013) Yuan Mao et al. ANALYTICAL CHEMISTRY
- Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody–Drug Conjugates
- (2013) Jia Chen et al. ANALYTICAL CHEMISTRY
- Ion mobility-mass spectrometry of intact protein–ligand complexes for pharmaceutical drug discovery and development
- (2013) Shuai Niu et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
- (2013) Hui Wei et al. DRUG DISCOVERY TODAY
- Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements
- (2013) Roxana E. Iacob et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Complementary MS Methods Assist Conformational Characterization of Antibodies with Altered S–S Bonding Networks
- (2013) Lisa M. Jones et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry
- (2013) Natalie J Thompson et al. mAbs
- Performing native mass spectrometry analysis on therapeutic antibodies
- (2013) Natalie J. Thompson et al. METHODS
- Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing
- (2013) P. Both et al. Nature Chemistry
- Ion Mobility Mass Spectrometry of Peptide Ions: Effects of Drift Gas and Calibration Strategies
- (2012) Matthew F. Bush et al. ANALYTICAL CHEMISTRY
- Qualitative and Semiquantitative Analysis of Composite Mixtures of Antibodies by Native Mass Spectrometry
- (2012) Sara Rosati et al. ANALYTICAL CHEMISTRY
- Bound Cations Significantly Stabilize the Structure of Multiprotein Complexes in the Gas Phase
- (2012) Linjie Han et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry
- (2012) Sara Rosati et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structure of Triplex DNA in the Gas Phase
- (2012) Annalisa Arcella et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Marketed therapeutic antibodies compendium
- (2012) Janice M. Reichert mAbs
- Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS
- (2012) Luca Fornelli et al. MOLECULAR & CELLULAR PROTEOMICS
- High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies
- (2012) Rebecca J Rose et al. NATURE METHODS
- Traveling-wave ion mobility mass spectrometry of protein complexes: accurate calibrated collision cross-sections of human insulin oligomers
- (2012) Rune Salbo et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Characterizing the resolution and accuracy of a second-generation traveling-wave ion mobility separator for biomolecular ions
- (2011) Yueyang Zhong et al. ANALYST
- Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry
- (2011) Yury O. Tsybin et al. ANALYTICAL CHEMISTRY
- Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies
- (2011) Hao Zhang et al. ANALYTICAL CHEMISTRY
- Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics
- (2011) Igor A. Kaltashov et al. BIOTECHNOLOGY ADVANCES
- Mass spectrometry: come of age for structural and dynamical biology
- (2011) Justin LP Benesch et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Bound Anions Differentially Stabilize Multiprotein Complexes in the Absence of Bulk Solvent
- (2011) Linjie Han et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ion mobility mass spectrometry for peptide analysis
- (2011) Sophie R. Harvey et al. METHODS
- Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange
- (2011) Aming Zhang et al. PHARMACEUTICAL RESEARCH
- Enhancements in travelling wave ion mobility resolution
- (2011) Kevin Giles et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry
- (2011) Rebecca J. Rose et al. STRUCTURE
- Resolving Disulfide Structural Isoforms of IgG2 Monoclonal Antibodies by Ion Mobility Mass Spectrometry
- (2010) Dhanashri Bagal et al. ANALYTICAL CHEMISTRY
- Collision Cross Sections of Proteins and Their Complexes: A Calibration Framework and Database for Gas-Phase Structural Biology
- (2010) Matthew F. Bush et al. ANALYTICAL CHEMISTRY
- Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly
- (2010) Hao Zhang et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding
- (2010) Damian Houde et al. MOLECULAR & CELLULAR PROTEOMICS
- Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography
- (2010) Başak Kükrer et al. PHARMACEUTICAL RESEARCH
- An improved trypsin digestion method minimizes digestion-induced modifications on proteins
- (2009) Da Ren et al. ANALYTICAL BIOCHEMISTRY
- Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry
- (2009) Damian Houde et al. ANALYTICAL CHEMISTRY
- Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS
- (2009) Cédric Atmanene et al. ANALYTICAL CHEMISTRY
- Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes
- (2009) Suk-Joon Hyung et al. CHEMISTRY & BIOLOGY
- Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer
- (2009) Pavel V. Bondarenko et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab
- (2009) Carola W. N. Damen et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Electrospray: From ions in solution to ions in the gas phase, what we know now
- (2009) Paul Kebarle et al. MASS SPECTROMETRY REVIEWS
- Ion mobility-mass spectrometry
- (2008) Abu B. Kanu et al. JOURNAL OF MASS SPECTROMETRY
- Native mass spectrometry: a bridge between interactomics and structural biology
- (2008) Albert J R Heck NATURE METHODS
- Ion mobility–mass spectrometry analysis of large protein complexes
- (2008) Brandon T Ruotolo et al. Nature Protocols
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now