Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry

Ion mobility spectrometry reveals intermediate states in temperature-resolved DNA unfolding

(2017) B. Hommersom et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Joule Heating and Thermal Denaturation of Proteins in Nano-ESI Theta Tips

(2017) Feifei Zhao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Immunogenicity of Therapeutic Protein Aggregates

(2016) Ehab M. Moussa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Ultrafast (1 μs) Mixing and Fast Protein Folding in Nanodrops Monitored by Mass Spectrometry

(2016) Daniel N. Mortensen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen

(2016) Guanbo Wang et al.   MOLECULAR CELL

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Conformational effects in protein electrospray-ionization mass spectrometry

(2015) Jinyu Li et al.   MASS SPECTROMETRY REVIEWS

Comprehensive Characterization of Relationship Between Higher-Order Structure and FcRn Binding Affinity of Stress-Exposed Monoclonal Antibodies

(2015) Daisuke Tsuchida et al.   PHARMACEUTICAL RESEARCH

Temperature denaturation and aggregation of a multi-domain protein (IgG1) investigated with an array of complementary biophysical methods

(2014) E. Cerasoli et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization

(2014) Rachel R. Ogorzalek Loo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

Mass spectrometry-based methods to study protein architecture and dynamics

(2013) Igor A. Kaltashov et al.   PROTEIN SCIENCE

The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

(2012) Sandeep Yadav et al.   MOLECULAR PHARMACEUTICS

Direct Monitoring of Heat-Stressed Biopolymers with Temperature-Controlled Electrospray Ionization Mass Spectrometry

(2011) Guanbo Wang et al.   ANALYTICAL CHEMISTRY

Charge-Surface Correlation in Electrospray Ionization of Folded and Unfolded Proteins

(2011) Lorenzo Testa et al.   ANALYTICAL CHEMISTRY

Evaluation of Electrospray Ionization Mass Spectrometry as a Tool for Characterization of Small Soluble Protein Aggregates

(2011) Guanbo Wang et al.   ANALYTICAL CHEMISTRY

Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics

(2011) Igor A. Kaltashov et al.   BIOTECHNOLOGY ADVANCES

Advanced Mass Spectrometry-Based Methods for the Analysis of Conformational Integrity of Biopharmaceutical Products

(2011) Cedric E. Bobst et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

An Electrostatic Charge Partitioning Model for the Dissociation of Protein Complexes in the Gas Phase

(2011) Stephen V. Sciuto et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Origin of supercharging in electrospray ionization of noncovalent complexes from aqueous solution

(2009) Harry J. Sterling et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

New reagents for increasing ESI multiple charging of proteins and protein complexes

(2009) Shirley H. Lomeli et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Protein stability modulated by a conformational effector: effects of trifluoroethanol on bovine serum albumin

(2009) Rita Carrotta et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

(2009) Christian Beyschau Andersen et al.   PROTEIN SCIENCE

Elucidation of Two Major Aggregation Pathways in an IgG2 Antibody

(2008) Nicholas Van Buren et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Principles, approaches, and challenges for predicting protein aggregation rates and shelf life

(2008) William F. Weiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Do Ionic Charges in ESI MS Provide Useful Information on Macromolecular Structure?

(2008) I KALTASHOV et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Microcalorimetry: a response to challenges in modern biotechnology

(2008) Tino Krell   Microbial Biotechnology

Self-Buffering Antibody Formulations

(2007) Yatin R. Gokarn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES