Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel

Development and Evaluation of a Reverse-Entry Ion Source Orbitrap Mass Spectrometer

(2018) Michael L. Poltash et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

(2018) Jani Reddy Bolla et al.   Nature Chemistry

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allostery revealed within lipid binding events to membrane proteins

(2018) John W. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry

(2018) Michael L. Poltash et al.   ANALYTICAL CHEMISTRY

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins

(2018) Jennifer L. Lippens et al.   ANALYTICAL CHEMISTRY

Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation

(2017) I-Shan Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

Allosteric modulation of protein-protein interactions by individual lipid binding events

(2017) Xiao Cong et al.   Nature Communications

Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

(2017) Hsin-Yung Yen et al.   Science Advances

Drugging Membrane Protein Interactions

(2016) Hang Yin et al.   Annual Review of Biomedical Engineering

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids

(2016) Sun-Joo Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

Determining Membrane Protein–Lipid Binding Thermodynamics Using Native Mass Spectrometry

(2016) Xiao Cong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Membrane Protein–Lipid Interactions by Mass Spectrometry Ion Mobility Mass Spectrometry

(2016) Yang Liu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

High-resolution mass spectrometry of small molecules bound to membrane proteins

(2016) Joseph Gault et al.   NATURE METHODS

Novel cell-free high-throughput screening method for pharmacological tools targeting K+channels

(2016) Zhenwei Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery: An Overview of Its History, Concepts, Methods, and Applications

(2016) Jin Liu et al.   PLoS Computational Biology

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

The Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase

(2015) Eamonn Reading et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels

(2015) S. K. Adney et al.   JOURNAL OF NEUROSCIENCE

Quantifying the stabilizing effects of protein–ligand interactions in the gas phase

(2015) Timothy M. Allison et al.   Nature Communications

Charge Reduction Stabilizes Intact Membrane Protein Complexes for Mass Spectrometry

(2014) Shahid Mehmood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Phosphoinositide regulation of inward rectifier potassium (Kir) channels

(2014) Oliver Fürst et al.   Frontiers in Physiology

Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry

(2013) Dragana Cubrilovic et al.   ACS Chemical Biology

Energetics and Location of Phosphoinositide Binding in Human Kir2.1 Channels

(2013) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels

(2013) Sun-Joo Lee et al.   Nature Communications

Two decades of studying non-covalent biomolecular assemblies by means of electrospray ionization mass spectrometry

(2012) G. R. Hilton et al.   Journal of the Royal Society Interface

Dual-Mode Phospholipid Regulation of Human Inward Rectifying Potassium Channels

(2011) Wayland W.L. Cheng et al.   BIOPHYSICAL JOURNAL

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Genetic defects in the hotspot of inwardly rectifying K+ (Kir) channels and their metabolic consequences: A review

(2011) Bikash R. Pattnaik et al.   MOLECULAR GENETICS AND METABOLISM

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Direct and Specific Activation of Human Inward Rectifier K+Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Gas-Phase Unfolding and Disassembly Reveals Stability Differences in Ligand-Bound Multiprotein Complexes

(2009) Suk-Joon Hyung et al.   CHEMISTRY & BIOLOGY

A discrete alcohol pocket involved in GIRK channel activation

(2009) Prafulla Aryal et al.   NATURE NEUROSCIENCE

Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels

(2009) H. J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics