A Land of Controversy: Fibroblast Growth Factor-23 and Uremic Cardiac Hypertrophy

Evolving concepts in the pathogenesis of uraemic cardiomyopathy

(2019) Xiaoliang Wang et al.   Nature Reviews Nephrology

Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway

(2019) Jon D. Wright et al.   FASEB JOURNAL

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

(2019) Ai-hua Zhang et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease

(2019) Connor Francis et al.   KIDNEY INTERNATIONAL

FGF23 induced left ventricular hypertrophy mediated by FGFR4 signaling in the myocardium is attenuated by soluble Klotho in mice

(2019) Xiaobin Han et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation

(2018) Xiaomin Zhang et al.   BMC BIOTECHNOLOGY

X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment

(2018) Yuka Kinoshita et al.   ENDOCRINE REVIEWS

Cardiac hypertrophy elevates serum levels of fibroblast growth factor 23

(2018) Isao Matsui et al.   KIDNEY INTERNATIONAL

The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk

(2018) Eva-Maria Pastor-Arroyo et al.   KIDNEY INTERNATIONAL

Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts

(2018) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study

(2018) Hyo Jin Kim et al.   BMC Nephrology

Crosstalk between FGF23- and angiotensin II-mediated Ca2+ signaling in pathological cardiac hypertrophy

(2018) Ketaki N. Mhatre et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Cardiovascular Interactions between Fibroblast Growth Factor-23 and Angiotensin II

(2018) Min Pi et al.   Scientific Reports

The systemic nature of CKD

(2017) Carmine Zoccali et al.   Nature Reviews Nephrology

Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling

(2017) George Dalton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights into the Mechanism of Action of Soluble Klotho

(2017) George D. Dalton et al.   Frontiers in Endocrinology

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible

(2017) Alexander Grabner et al.   Scientific Reports

Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine

(2016) Ioana Alesutan et al.   CARDIOVASCULAR RESEARCH

The role of fibroblast growth factor 23 and Klotho in uremic cardiomyopathy

(2016) Alexander Grabner et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Patients with FGF23-related hypophosphatemic rickets/osteomalacia do not present with left ventricular hypertrophy

(2016) Yuichi Takashi et al.   ENDOCRINE RESEARCH

Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2D in macrophages

(2016) Xiaobin Han et al.   FEBS LETTERS

FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients

(2016) Mehmet Nuri Turan et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

FGF23 signaling impairs neutrophil recruitment and host defense during CKD

(2016) Jan Rossaint et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum fibroblast growth factor-23 and incident hypertension

(2016) Amber L. Fyfe-Johnson et al.   JOURNAL OF HYPERTENSION

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease

(2016) Saurav Singh et al.   KIDNEY INTERNATIONAL

Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells

(2016) Beatrice Richter et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Soluble klotho and mortality: The Ludwigshafen Risk and Cardiovascular Health Study

(2015) Vincent M. Brandenburg et al.   ATHEROSCLEROSIS

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

(2015) Alexander Grabner et al.   Cell Metabolism

α-Klotho Expression in Human Tissues

(2015) Kenneth Lim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes

(2015) Junnan Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy

(2015) K. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats

(2015) Cynthia S. Ritter et al.   KIDNEY INTERNATIONAL

Klotho ameliorated isoproterenol-induced pathological changes in cardiomyocytes via the regulation of oxidative stress

(2015) Shuang Song et al.   LIFE SCIENCES

Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease

(2015) Maren Leifheit-Nestler et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Solubleα-Klotho Serum Levels in Chronic Kidney Disease

(2015) Silverio Rotondi et al.   International Journal of Endocrinology

αKlotho and vascular calcification

(2014) Ming Chang Hu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

FGF23 regulates renal sodium handling and blood pressure

(2014) Olena Andrukhova et al.   EMBO Molecular Medicine

Soluble Klotho levels in adult renal transplant recipients are modulated by recombinant human erythropoietin

(2014) Francesca Leone et al.   JOURNAL OF NEPHROLOGY

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

(2014) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

(2014) J. Xie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia

(2014) Paula Buendía et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium

(2014) Isabelle Six et al.   PLoS One

Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients

(2014) Maurits S Buiten et al.   BMC Nephrology

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

(2014) Kook Hwan Kim et al.   Diabetes & Metabolism Journal

FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy

(2013) Chad D. Touchberry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Validation of an Immunoassay for Soluble Klotho Protein

(2012) Sridevi Devaraj et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes

(2012) Justine Bacchetta et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Biological Variability of Plasma Intact and C-Terminal FGF23 Measurements

(2012) Edward R. Smith et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

(2012) Victoria Shalhoub et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

(2012) Wei Ling Lau et al.   KIDNEY INTERNATIONAL

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

(2012) L. Darryl Quarles   Nature Reviews Endocrinology

Secreted Klotho and FGF23 in chronic kidney disease Stage 1 to 5: a sequence suggested from a cross-sectional study

(2012) Ivana Pavik et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fibroblast growth factor 23 and left ventricular hypertrophy in children on dialysis

(2012) Wacharee Seeherunvong et al.   PEDIATRIC NEPHROLOGY

A Comparative Transcriptome Analysis Identifying FGF23 Regulated Genes in the Kidney of a Mouse CKD Model

(2012) Bing Dai et al.   PLoS One

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

Circulating levels of soluble α-Klotho in patients with chronic kidney disease

(2011) Hidekazu Sugiura et al.   Clinical and Experimental Nephrology

Fibroblast Growth Factor 23 and Risks of Mortality and End-Stage Renal Disease in Patients With Chronic Kidney Disease

(2011) Tamara Isakova   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serum Fibroblast Growth Factor-23 Levels and Progression of Aortic Arch Calcification in Non-Diabetic Patients on Chronic Hemodialysis

(2011) Noriko Tamei et al.   Journal of Atherosclerosis and Thrombosis

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Elevated Fibroblast Growth Factor 23 is a Risk Factor for Kidney Transplant Loss and Mortality

(2011) M. Wolf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cross Talk Between the Renin-Angiotensin-Aldosterone System and Vitamin D-FGF-23-klotho in Chronic Kidney Disease

(2011) M. H. de Borst et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

(2011) Tamara Isakova et al.   KIDNEY INTERNATIONAL

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

Cardioprotective effect of calcineurin inhibition in an animal model of renal disease

(2010) Giovana S. Di Marco et al.   EUROPEAN HEART JOURNAL

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells

(2010) Q. Zhou et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease

(2010) Hisashi Hasegawa et al.   KIDNEY INTERNATIONAL

FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease

(2010) Mahmut I. Yilmaz et al.   KIDNEY INTERNATIONAL

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients

(2010) A. Kirkpantur et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy

(2010) H. E. Yoon et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23

(2009) Peidang Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fibroblast Growth Factor 23: A Possible Cause of Left Ventricular Hypertrophy in Hemodialysis Patients

(2009) Heng Jung Hsu et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Tumor Necrosis Factor and Interferon-γ Down-regulate Klotho in Mice With Colitis

(2009) Robert D. Thurston et al.   GASTROENTEROLOGY

Circulating Fibroblast Growth Factor 23 in Patients with End-Stage Renal Disease Treated by Peritoneal Dialysis Is Intact and Biologically Active

(2009) Takashi Shimada et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated Atherosclerotic Calcification and Monckeberg's Sclerosis: A Continuum of Advanced Vascular Pathology in Chronic Kidney Disease

(2008) P. A. McCullough et al.   Clinical Journal of the American Society of Nephrology

Physiological Regulation and Disorders of Phosphate Metabolism -Pivotal Role of Fibroblast Growth Factor 23-

(2008) Seiji Fukumoto   INTERNAL MEDICINE

Amelioration of the premature ageing-like features ofFgf-23knockout mice by genetically restoring the systemic actions of FGF-23

(2008) S DeLuca et al.   JOURNAL OF PATHOLOGY

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE