Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

A Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation

(2019) Elin Byman et al.   JOURNAL OF ALZHEIMERS DISEASE

Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson’s disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy

(2019) Junge Zhu et al.   BRAIN RESEARCH

Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease

(2019) Nathan A. Bihlmeyer et al.   Alzheimers & Dementia

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity

(2019) Lindsay T. Michalovicz et al.   JOURNAL OF NEUROCHEMISTRY

Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer’s disease

(2019) Isabel Carreras et al.   Scientific Reports

Interleukin-33 reduces neuronal damage and white matter injury via selective microglia M2 polarization after intracerebral hemorrhage in rats

(2019) Zhouqing Chen et al.   BRAIN RESEARCH BULLETIN

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Brain alpha-amylase: a novel energy regulator important in Alzheimer disease?

(2018) Elin Byman et al.   BRAIN PATHOLOGY

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

(2018) D. M. Vargas et al.   Alzheimers Research & Therapy

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

(2018) Minghui Wang et al.   Scientific Data

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

(2018) Philip L. De Jager et al.   Scientific Data

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain

(2018) Tina Heiland et al.   GLIA

Stroke target identification guided by astrocyte transcriptome analysis

(2018) Cordula Rakers et al.   GLIA

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model

(2018) Sean J. Miller et al.   JOURNAL OF NEUROGENETICS

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

(2017) Pradoldej Sompol et al.   JOURNAL OF NEUROSCIENCE

ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury

(2017) Yuanyuan Yang et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

IL-33 Provides Neuroprotection through Suppressing Apoptotic, Autophagic and NF-κB-Mediated Inflammatory Pathways in a Rat Model of Recurrent Neonatal Seizure

(2017) Yuan Gao et al.   Frontiers in Molecular Neuroscience

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

(2017) Marta Sidoryk-Wegrzynowicz et al.   Acta Neuropathologica Communications

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model

(2016) T. Draheim et al.   GLIA

Spinal cord injury induces astroglial conversion towards neuronal lineage

(2016) Harun Najib Noristani et al.   Molecular Neurodegeneration

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Role of Matricellular Proteins in Disorders of the Central Nervous System

(2016) A. R. Jayakumar et al.   NEUROCHEMICAL RESEARCH

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage

(2016) Haijun Bao et al.   NEUROSCIENCE LETTERS

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease

(2016) Nurgul Aytan et al.   Scientific Reports

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

(2015) Yuriy Pomeshchik et al.   BRAIN BEHAVIOR AND IMMUNITY

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival

(2015) Jaclynn Levine et al.   GLIA

Cholesterol-induced astrocyte activation is associated with increased amyloid precursor protein expression and processing

(2015) Evangelina Avila-Muñoz et al.   GLIA

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Thrombospondin-1 prevents amyloid beta–mediated synaptic pathology in Alzheimer's disease

(2015) Sung Min Son et al.   NEUROBIOLOGY OF AGING

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

(2015) Sachin P. Gadani et al.   NEURON

Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy

(2015) Tomoya Kon et al.   NEUROPATHOLOGY

Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93Atransgenic mice

(2015) Yuko Kobayakawa et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice

(2015) H. Chen et al.   NEUROSCIENCE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system

(2015) Anna R. Malik et al.   Frontiers in Cellular Neuroscience

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Nrf2 Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning

(2014) Jiajun Xu et al.   JOURNAL OF NEUROTRAUMA

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Apelin-13 Attenuates Traumatic Brain Injury-Induced Damage by Suppressing Autophagy

(2014) Hai-Jun Bao et al.   NEUROCHEMICAL RESEARCH

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms

(2014) Brigit E. Riley et al.   PLoS One

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

(2014) Emma V. Jones et al.   NEURAL PLASTICITY

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

Cyr61, a Matricellular Protein, Is Needed for Dendritic Arborization of Hippocampal Neurons

(2013) Anna R. Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GATAD2Bloss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth inDrosophila

(2013) Marjolein H Willemsen et al.   JOURNAL OF MEDICAL GENETICS

Amyloid-β Inhibits Thrombospondin 1 Release From Cultured Astrocytes: Effects on Synaptic Protein Expression

(2013) Kakulavarapu V. Rama Rao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

(2013) Corinne Brana et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Developmental expression of IL-33 in the mouse brain

(2013) Grzegorz Wicher et al.   NEUROSCIENCE LETTERS

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

(2012) Willem Kamphuis et al.   GLIA

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective and reparative effects of carotid body grafts in a chronic MPTP model of Parkinson's disease

(2012) Ana B. Muñoz-Manchado et al.   NEUROBIOLOGY OF AGING

Early Induction of Oxidative Stress in Mouse Model of Alzheimer Disease with Reduced Mitochondrial Superoxide Dismutase Activity

(2012) Hyun-Pil Lee et al.   PLoS One

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Apelin Deficiency Accelerates the Progression of Amyotrophic Lateral Sclerosis

(2011) Atsushi Kasai et al.   PLoS One

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

(2010) Ruben Van Doorn et al.   GLIA

Cellular Localization of Sphingosine-1-phosphate Receptor 1 Expression in the Human Central Nervous System

(2010) Hirotake Nishimura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia

(2010) Wen-Sheng Qu et al.   JOURNAL OF NEUROCHEMISTRY

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Galectin-1 Enhances Astrocytic BDNF Production and Improves Functional Outcome in Rats Following Ischemia

(2010) Wen-sheng Qu et al.   NEUROCHEMICAL RESEARCH

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

(2009) Çagla Eroglu et al.   CELL

MAPK induces AQP1 expression in astrocytes following injury

(2009) Eric Mccoy et al.   GLIA

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Sonic Hedgehog Pathway Activation Is Induced by Acute Brain Injury and Regulated by Injury-Related Inflammation

(2009) N. M. Amankulor et al.   JOURNAL OF NEUROSCIENCE

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration

(2008) Angelo C. Lepore et al.   EXPERIMENTAL NEUROLOGY

Type-Dependent Oxidative Damage in Frontotemporal Lobar Degeneration: Cortical Astrocytes Are Targets of Oxidative Damage

(2008) Anna Martínez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA