Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Ying Chen, Yan Dong, Zai-Li Zhang, Jie Han, Feng-Shou Chen, Xiang-Yi Tong, Hong Ma
Summary: This study demonstrates that Fra-1 plays a promoting role in apoptosis and inflammation in spinal cord ischemia/reperfusion injury. It is found that S100A8 is an upstream regulator of Fra-1 and the interaction between Fra-1 and S100A8 forms a feedback loop in the signaling pathways activated by this injury.
Article
Neurosciences
Haiyun Guo, Zhen Zhang, Tingting Gu, Doutong Yu, Yanru Shi, Zejun Gao, Zhongheng Wang, Wenming Liu, Ze Fan, Wugang Hou, Huaning Wang, Yanhui Cai
Summary: This study found that Salvianolic acid B (SAB) has a neuroprotective effect on brain reperfusion injury by accelerating glycogenolysis in astrocytes. Inhibition of glycogenolysis weakens the neuroprotective effect of SAB.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Amita Daverey, Sandeep K. Agrawal
Summary: This study reveals the protective role of Prdx6 in spinal cord white matter against hypoxia-reperfusion injury, possibly through astrocytes and the Nrf2 signaling pathway.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Jinying Xu, Tong Ji, Guichen Li, Haiying Zhang, Yangyang Zheng, Meiying Li, Jie Ma, Yulin Li, Guangfan Chi
Summary: The study reveals that under conditions of ischemia or oxygen-glucose deprivation (OGD), lactate stabilizes NDRG2 in astrocytes by inhibiting its ubiquitination, which plays an important anti-inflammatory role and inhibits TNF alpha expression and secretion. This finding suggests that NDRG2 may be a potential therapeutic target for cerebral ischemia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Yifeng Xu, Boqian Wang, Xiaoxiao Liu, Yunfei Deng, Yanqi Zhu, Feng Zhu, Yanyan Liang, Hongli Li
Summary: This study investigated the role and mechanism of PARP1 in MIRI, demonstrating that inhibition of PARP1 can protect cardiomyocytes from MIRI by regulating autophagy. Additionally, it was found that Sp1, a transcription factor of PARP1, plays a role in this process by binding to the target gene promoter of PARP1 during transcription. These findings suggest that targeting PARP1 has great therapeutic potential for MIRI in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shun-Da Wang, Ying-Ying Fu, Xin-Yuan Han, Zhi-Jun Yong, Qing Li, Zhen Hu, Zhen-Guo Liu
Summary: The study demonstrated that HBO preconditioning for five days can provide significant protection in a rat stroke model, showing that HBO-PC can alleviate ischemia/reperfusion injury by inhibiting mitochondrial apoptosis and regulating energy metabolism. XIAP and SMAC signaling pathways play important roles in the protective effects of HBO-PC.
NEUROCHEMICAL RESEARCH
(2021)
Article
Clinical Neurology
Ilcim Ermutlu, Ramazan Fesli, Ata Turker Arikok, Berrin Imge Erguder, Hayri Kertmen, Bora Gurer
Summary: This study aimed to evaluate the neuroprotective effects of niacin on spinal cord ischemia/reperfusion injury. Rabbits were divided into four groups and treated with different interventions. The results showed that treatment with niacin and methylprednisolone led to improvements in histopathological, ultrastructural, and neurological assessments. The study suggests that niacin has similar neuroprotective effects to methylprednisolone in this type of injury.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Robert P. Ostrowski, Emanuela Pucko, Ewa Matyja
Summary: This study investigated the role of the proteasome in the mechanism of preconditioning with hyperbaric oxygen (HBO-PC). The results showed that HBO-PC can protect the brain against severe ischemic brain insult and this protection may be linked to a depletion of apoptotic proteins and improved regenerative potential.
FRONTIERS IN NEUROLOGY
(2022)
Article
Physiology
Fang Su, Huajun Yang, Anchen Guo, Zhengyi Qu, Jianping Wu, Qun Wang
Summary: Low-dose ethanol preconditioning can alleviate neuronal apoptosis during oxygen-glucose deprivation and reperfusion by activating the BKCa channel, and also modulate mitochondrial function by reducing the expression of apoptosis-related proteins.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vivian Doerr, Ryan N. Montalvo, Branden L. Nguyen, Franccesco P. Boeno, Michael D. Sunshine, Victoria E. Bindi, David D. Fuller, Ashley J. Smuder
Summary: DOX chemotherapy can lead to cardiorespiratory dysfunction, while HBO therapy may increase muscle antioxidant expression. However, HBO therapy is not sufficient to prevent DOX-induced cardiorespiratory dysfunction.
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Guangxu Xiao, Ming Lyu, Zhixiong Li, Linghua Cao, Xinyan Liu, Yule Wang, Shuang He, Zihao Chen, Hongxia Du, Yuxin Feng, Jigang Wang, Yan Zhu
Summary: This study demonstrates the critical role of SHH-PTCH1-GLI1-mediated axonal guidance signaling in the early stages of acute stroke, providing a novel clinical treatment option for acute ischemic stroke using GXNI. The experiments showed that GXNI significantly alleviated cerebral ischemic reperfusion injury by reducing cerebral infarction volume and improving neurological deficits. Additionally, GXNI promoted axon growth and synaptogenesis of damaged neurons, further confirming the results of in vivo experiments.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Toxicology
J. Bai, P. Jia, Y. Zhang, K. Wang, G. Wu
Summary: PON2 plays a crucial role in protecting neurons against oxidative stress induced by cerebral ischemia-reperfusion injury. Upregulation of PON2 improves neuronal viability, reduces apoptosis, and attenuates reactive oxygen species levels under oxidative stress. PON2 achieves this neuroprotective effect by potentiating Nrf2 activation through modulation of GSK-3 beta.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)