Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

(2012) P Gergely et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

(2012) Ruben van Doorn et al.   Journal of Neuroinflammation

Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions

(2011) María I. Gaitán et al.   ANNALS OF NEUROLOGY

Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system

(2011) Mirjam Schuchardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insights into the pharmacological relevance of lysophospholipid receptors

(2011) Tetsuji Mutoh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

(2011) Hye Jung Kim et al.   FASEB JOURNAL

Neurovascular function in Alzheimer's disease patients and experimental models

(2011) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Fingolimod modulates microglial activation to augment markers of remyelination

(2011) Samuel J Jackson et al.   Journal of Neuroinflammation

The role of advanced magnetic resonance imaging techniques in primary progressive MS

(2011) Maria A. Rocca et al.   JOURNAL OF NEUROLOGY

Oral treatment for multiple sclerosis

(2011) Joep Killestein et al.   LANCET NEUROLOGY

Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy

(2011) R. Hohlfeld et al.   NEUROLOGY

Review: The architecture of inflammatory demyelinating lesions: implications for studies on pathogenesis

(2011) H. Lassmann   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions

(2011) Iris Fischer et al.   PLoS One

Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis

(2010) Chang Wook Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Inflammation, demyelination, and degeneration — Recent insights from MS pathology

(2010) Christine Stadelmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling

(2010) Tomoya Ohno et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Design and Synthesis of Selective and Potent Orally Active S1P5 Agonists

(2010) Henri Mattes et al.   ChemMedChem

Cellular Localization of Sphingosine-1-phosphate Receptor 1 Expression in the Human Central Nervous System

(2010) Hirotake Nishimura et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Differential responses of human microglia and blood-derived myeloid cells to FTY720

(2010) Bryce A. Durafourt et al.   JOURNAL OF NEUROIMMUNOLOGY

Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology

(2010) Cornelia Laule et al.   Multiple Sclerosis Journal

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Cortical lesions and cognitive impairment in multiple sclerosis

(2010) F. Rinaldi et al.   NEUROLOGICAL SCIENCES

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

(2010) Ranjan Dutta et al.   PROGRESS IN NEUROBIOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Diffusely Abnormal White Matter in Chronic Multiple Sclerosis

(2009) Alexandra Seewann et al.   ARCHIVES OF NEUROLOGY

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Cortical pathology in multiple sclerosis

(2009) Christine Stadelmann et al.   CURRENT OPINION IN NEUROLOGY

Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system

(2009) H. Meng et al.   DEVELOPMENTAL DYNAMICS

Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod

(2008) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular and lymphatic endothelial cells

(2008) Takashi Akiyama et al.   JOURNAL OF MOLECULAR HISTOLOGY

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

(2007) Kumlesh K. Dev et al.   PHARMACOLOGY & THERAPEUTICS