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Fingolimod effect on brain volume loss independently contributes to its effect on disability

(2015) MP Sormani et al.   Multiple Sclerosis Journal

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

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Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

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Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

(2013) Celina Wu et al.   Journal of Neuroinflammation

Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration

(2013) Silvia Rossi et al.   Multiple Sclerosis Journal

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

B cells and antibodies in multiple sclerosis pathogenesis and therapy

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Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

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An autocrine sphingosine-1-phosphate signaling loop enhances NF-κB-activation and survival

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Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

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More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

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A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

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IL-11 Regulates Autoimmune Demyelination

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Identification of BLyS (B Lymphocyte Stimulator), a Non-Myelin-Associated Protein, as a Functional Ligand for Nogo-66 Receptor

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina

(2009) Srinivas Chollangi et al.   NEUROBIOLOGY OF DISEASE

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Interferon-β increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity

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Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis

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