Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

Generation of two iPSC lines (FAMRCi006-A and FAMRCi006-B) from patient with dilated cardiomyopathy and Emery–Dreifuss muscular dystrophy associated with genetic variant LMNAp.Arg527Pro.

(2020) Kseniya Perepelina et al.   Stem Cell Research

Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells

(2020) Xinchao Hu et al.   Stem Cells International

Fabricating retinal pigment epithelial cell sheets derived from human induced pluripotent stem cells in an automated closed culture system for regenerative medicine

(2019) Erino Matsumoto et al.   PLoS One

‘Reprogrammed’ stem cells to treat spinal-cord injuries for the first time

(2019) David Cyranoski   NATURE

Results of the First Completed Clinical Trial of an iPSC-Derived Product: CYP-001 in Steroid-Resistant Acute GvHD

(2019) John E.J. Rasko et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

(2019) Stephen Attwood et al.   Journal of Clinical Medicine

Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform

(2019) Juan Antonio Garcia-Leon et al.   Future Medicinal Chemistry

Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

(2019) José Bragança et al.   World Journal of Stem Cells

Modeling Alzheimer’s disease with iPSC-derived brain cells

(2019) Jay Penney et al.   MOLECULAR PSYCHIATRY

Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer’s Disease

(2019) Chiara A. Elia et al.   Cells

A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies—In Vitro and In Vivo Treatments to Boost Cellular Engraftment

(2019) Daniela Gois Beghini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Pluripotent Stem Cell-Derived Extracellular Vesicles: Characteristics and Applications

(2019) Richard Jeske et al.   TISSUE ENGINEERING PART B-REVIEWS

Generation of a human induced pluripotent stem cell–based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration

(2018) Juan Antonio García-León et al.   Alzheimers & Dementia

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

(2018) Robin L. Webb et al.   STROKE

Human pluripotent reprogramming with CRISPR activators

(2018) Jere Weltner et al.   Nature Communications

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

(2018) Sara Martina Maffioletti et al.   Cell Reports

Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

(2018) Adekunle Ebenezer Omole et al.   PeerJ

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing

(2018) Chengzu Long et al.   Science Advances

Patient-derived induced pluripotent stem cells for models of cancer and cancer stem cell research

(2018) Hsiao-Mei Chao et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

‘Reprogrammed’ stem cells approved to mend human hearts for the first time

(2018) David Cyranoski   NATURE

Japan must tighten up clinical trial of stem cells for heart failure

(2018) Akira Akabayashi et al.   NATURE

Modeling Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells

(2018) Hong Li et al.   Journal of Parkinsons Disease

‘Reprogrammed’ stem cells implanted into patient with Parkinson’s disease

(2018) David Cyranoski   NATURE

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells

(2017) Ryuhei Hayashi et al.   Nature Protocols

Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

(2017) Juan Carlos Polanco et al.   Nature Reviews Neurology

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

microRNAs: important regulators of stem cells

(2017) Na Li et al.   Stem Cell Research & Therapy

Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

(2017) Peter Gee et al.   Stem Cells International

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?

(2017) Yoon-Ju Lim et al.   Acta Neuropathologica Communications

Techniques of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Derivation

(2016) Jarosław Lewandowski et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The use of human neurons for novel drug discovery in dementia research

(2016) Mariana Vargas-Caballero et al.   Expert Opinion on Drug Discovery

Advances in therapeutic CRISPR/Cas9 genome editing

(2016) Nataša Savić et al.   Translational Research

Characterization of Induced Pluripotent Stem Cell Microvesicle Genesis, Morphology and Pluripotent Content

(2016) Jing Zhou et al.   Scientific Reports

Pluripotent Stem Cells: Current Understanding and Future Directions

(2016) Antonio Romito et al.   Stem Cells International

Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates

(2016) Mattia Quattrocelli et al.   Stem Cell Reports

Cell Therapy in Duchenne Muscular Dystrophy Treatment: Clinical Trials Overview

(2015) Anna Bajek et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

(2015) Akvilė Jarmalavičiūtė et al.   CYTOTHERAPY

Current status of pluripotent stem cells: moving the first therapies to the clinic

(2015) Erin A. Kimbrel et al.   NATURE REVIEWS DRUG DISCOVERY

Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9

(2015) Hongmei Lisa Li et al.   Stem Cell Reports

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

iPS cell technologies: significance and applications to CNS regeneration and disease

(2014) Hideyuki Okano et al.   Molecular Brain

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery

(2013) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

(2013) Maria Sundberg et al.   STEM CELLS

Cell fate conversion by mRNA

(2013) Mo Li et al.   Stem Cell Research & Therapy

Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice

(2012) Radbod Darabi et al.   Cell Stem Cell

Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model

(2012) M. Kawamura et al.   CIRCULATION

Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease

(2012) Yong Soon Chun et al.   International Journal of Biological Sciences

Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells

(2012) Takuya Kuroda et al.   PLoS One

Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy

(2012) F. S. Tedesco et al.   Science Translational Medicine

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human-Induced Pluripotent Stem Cells form Functional Neurons and Improve Recovery After Grafting in Stroke-Damaged Brain

(2012) Koichi Oki et al.   STEM CELLS

Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model

(2012) Kilsoo Jeon et al.   STEM CELLS AND DEVELOPMENT

Nonhuman Primate Induced Pluripotent Stem Cells in Regenerative Medicine

(2012) Yuehong Wu et al.   Stem Cells International

Generation of hircine-induced pluripotent stem cells by somatic cell reprogramming

(2011) Jiangtao Ren et al.   CELL RESEARCH

Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors

(2011) Lei Bao et al.   CELL RESEARCH

Generation of induced pluripotent stem cells from bovine embryonic fibroblast cells

(2011) Xiaoping Han et al.   CELL RESEARCH

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

(2011) Frederick Anokye-Danso et al.   Cell Stem Cell

Preclinical Derivation and Imaging of Autologously Transplanted Canine Induced Pluripotent Stem Cells

(2011) Andrew S. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease

(2011) Yong-Hee Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

(2011) Budd A. Tucker et al.   PLoS One

Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors

(2011) Masaharu Hiratsuka et al.   PLoS One

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors

(2011) H. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins

(2011) H. Liu et al.   Science Translational Medicine

Optimization of Adenovirus Vectors for Transduction in Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2011) Katsuhisa TASHIRO   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

(2010) Xonia Carvajal-Vergara et al.   NATURE

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors

(2010) Kazim H Narsinh et al.   Nature Protocols

Regulation of somatic cell reprogramming through inducible mir-302 expression

(2010) Shi-Lung Lin et al.   NUCLEIC ACIDS RESEARCH

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cell Lines from Tibetan Miniature Pig

(2009) Miguel A. Esteban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

(2009) Keisuke Kaji et al.   NATURE

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

(2009) Ángel Raya et al.   NATURE

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells

(2009) Wenbo Zhou et al.   STEM CELLS

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Generation of Induced Pluripotent Stem Cell Lines from Adult Rat Cells

(2008) Jing Liao et al.   Cell Stem Cell

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Reprogramming of murine and human somatic cells using a single polycistronic vector

(2008) B. W. Carey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

(2008) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette

(2008) Cesar A. Sommer et al.   STEM CELLS