Current status of pluripotent stem cells: moving the first therapies to the clinic
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Current status of pluripotent stem cells: moving the first therapies to the clinic
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 14, Issue 10, Pages 681-692
Publisher
Springer Nature
Online
2015-09-22
DOI
10.1038/nrd4738
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes
- (2016) Shian-ling Ding et al. Clinical Interventions in Aging
- Long-term functional benefits of human embryonic stem cell-derived cardiac progenitors embedded into a fibrin scaffold
- (2015) Valérie Bellamy et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
- (2015) Jieyuan Zhang et al. Journal of Translational Medicine
- Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies
- (2015) Steven D Schwartz et al. LANCET
- Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients
- (2015) Won Kyung Song et al. Stem Cell Reports
- Derivation of Hair-Inducing Cell from Human Pluripotent Stem Cells
- (2015) Ksenia Gnedeva et al. PLoS One
- Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells
- (2015) Taku Tanaka et al. Scientific Reports
- Platelet bioreactor-on-a-chip
- (2014) J. N. Thon et al. BLOOD
- Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
- (2014) Hong Chen et al. Cell Stem Cell
- MSC-Based Product Characterization for Clinical Trials: An FDA Perspective
- (2014) Michael Mendicino et al. Cell Stem Cell
- Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells
- (2014) Lei Ye et al. Cell Stem Cell
- Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease
- (2014) Shane Grealish et al. Cell Stem Cell
- Modeling human lung development and disease using pluripotent stem cells
- (2014) H.-W. Snoeck DEVELOPMENT
- Targeted gene therapy and cell reprogramming in Fanconi anemia
- (2014) P. Rio et al. EMBO Molecular Medicine
- Towards a clinical use of human embryonic stem cell-derived cardiac progenitors: a translational experience
- (2014) Philippe Menasché et al. EUROPEAN HEART JOURNAL
- Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 andpiggyBac
- (2014) Fei Xie et al. GENOME RESEARCH
- Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
- (2014) James J. H. Chong et al. NATURE
- An in vivo model of human small intestine using pluripotent stem cells
- (2014) Carey L Watson et al. NATURE MEDICINE
- Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
- (2014) Pablo Tebas et al. NEW ENGLAND JOURNAL OF MEDICINE
- Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture
- (2014) Richard L. Gieseck III et al. PLoS One
- RNA Expression Profiling of Human iPSC-Derived Cardiomyocytes in a Cardiac Hypertrophy Model
- (2014) Praful Aggarwal et al. PLoS One
- Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
- (2014) Kosuke Funato et al. SCIENCE
- Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa
- (2014) V. Sebastiano et al. Science Translational Medicine
- Induced pluripotent stem cells from human revertant keratinocytes for the treatment of epidermolysis bullosa
- (2014) N. Umegaki-Arao et al. Science Translational Medicine
- Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
- (2014) A. D. Ebert et al. Science Translational Medicine
- Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2
- (2014) Koutaro Takamatsu et al. Stem Cell Research
- Mesenchymal Stem Cell Population Derived from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and Therapeutic Properties
- (2014) Erin A. Kimbrel et al. STEM CELLS AND DEVELOPMENT
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor
- (2014) Amiq Gazdhar et al. Stem Cell Research & Therapy
- Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
- (2014) Faye M. Drawnel et al. Cell Reports
- The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa
- (2014) Tetsu Yoshida et al. Molecular Brain
- Proceedings: Debilitating Eye Diseases
- (2014) Ingrid W. Caras et al. Stem Cells Translational Medicine
- Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson-Gilford Progeria Syndrome
- (2014) Sophie Blondel et al. Stem Cells Translational Medicine
- A Multiplex High-Throughput Gene Expression Assay to Simultaneously Detect Disease and Functional Markers in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium
- (2014) Marc Ferrer et al. Stem Cells Translational Medicine
- Chemically Induced Specification of Retinal Ganglion Cells From Human Embryonic and Induced Pluripotent Stem Cells
- (2014) Hamidreza Riazifar et al. Stem Cells Translational Medicine
- Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers
- (2014) Qing Liu et al. JAMA Neurology
- Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells
- (2014) Gabor Földes et al. Stem Cell Reports
- Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application
- (2014) Hiroyuki Kamao et al. Stem Cell Reports
- Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis
- (2014) Xiaofang Wang et al. Stem Cell Reports
- Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation
- (2014) Daisuke Doi et al. Stem Cell Reports
- Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells
- (2014) Qiang Feng et al. Stem Cell Reports
- Tenascin C Promotes Hematoendothelial Development and T Lymphoid Commitment from Human Pluripotent Stem Cells in Chemically Defined Conditions
- (2014) Gene Uenishi et al. Stem Cell Reports
- 3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
- (2014) Anastasia Petrova et al. Stem Cell Reports
- Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging
- (2014) Hoi-Hung Cheung et al. Stem Cell Reports
- Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients
- (2013) L. Garcon et al. BLOOD
- A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS
- (2013) Yin M. Yang et al. Cell Stem Cell
- Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays
- (2013) E. G. Navarrete et al. CIRCULATION
- Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
- (2013) Ping Liang et al. CIRCULATION
- The mesenchymal stromal cells dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
- (2013) Jacques Galipeau CYTOTHERAPY
- Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model
- (2013) Monica Nizzardo et al. HUMAN MOLECULAR GENETICS
- Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix
- (2013) Mahboobe Ghaedi et al. JOURNAL OF CLINICAL INVESTIGATION
- A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
- (2013) Matthew F. Burkhardt et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Vascularized and functional human liver from an iPSC-derived organ bud transplant
- (2013) Takanori Takebe et al. NATURE
- Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
- (2013) Changsung Kim et al. NATURE
- Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
- (2013) Sarah X L Huang et al. NATURE BIOTECHNOLOGY
- Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
- (2013) D. S. Welsbie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
- (2013) D. Sareen et al. Science Translational Medicine
- Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy
- (2013) Reto Eggenschwiler et al. Stem Cells Translational Medicine
- Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells
- (2013) Xiaocui Ma et al. Stem Cells Translational Medicine
- Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium
- (2013) David E. Buchholz et al. Stem Cells Translational Medicine
- Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation
- (2012) Philipp Koch et al. AMERICAN JOURNAL OF PATHOLOGY
- Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes
- (2012) The HD iPSC Consortium Cell Stem Cell
- Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells
- (2012) Blake Byers et al. Current Neurology and Neuroscience Reports
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- VPA response in SMA is suppressed by the fatty acid translocase CD36
- (2012) L. Garbes et al. HUMAN MOLECULAR GENETICS
- Assessing iPSC reprogramming methods for their suitability in translational medicine
- (2012) Mahendra S. Rao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Differentiation of Human Embryonic Stem Cells into Clinically Amenable Keratinocytes in an Autogenic Environment
- (2012) Fahad K. Kidwai et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Embryonic stem cell trials for macular degeneration: a preliminary report
- (2012) Steven D Schwartz et al. LANCET
- CD166pos Subpopulation From Differentiated Human ES and iPS Cells Support Repair of Acute Lung Injury
- (2012) Boon Seng Soh et al. MOLECULAR THERAPY
- Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
- (2012) Amy P Wong et al. NATURE BIOTECHNOLOGY
- Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
- (2012) Gabsang Lee et al. NATURE BIOTECHNOLOGY
- Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model
- (2012) Ena Ray Banerjee et al. PLoS One
- A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells
- (2012) Thomas C. Schulz et al. PLoS One
- Human Pluripotent Stem Cell-Derived Cardiomyocytes: Response to TTX and Lidocain Reveals Strong Cell to Cell Variability
- (2012) Xiaowu Sheng et al. PLoS One
- A GAL4-Driver Line Resource for Drosophila Neurobiology
- (2012) Arnim Jenett et al. Cell Reports
- Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
- (2012) Agnete Kirkeby et al. Cell Reports
- Translation of Stem Cell Research: Points to Consider in Designing Preclinical Animal Studies
- (2012) Joyce Frey-Vasconcells et al. Stem Cells Translational Medicine
- In vitropathological modelling using patient-specific induced pluripotent stem cells: the case of progeria
- (2011) Xavier Nissan et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
- (2011) Shi-Jiang Lu et al. CELL RESEARCH
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Modeling familial Alzheimer's disease with induced pluripotent stem cells
- (2011) Takuya Yagi et al. HUMAN MOLECULAR GENETICS
- Cellules souches embryonnaires humaines et iPS
- (2011) Thomas Touboul et al. M S-MEDECINE SCIENCES
- Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction
- (2011) Kazuo Takayama et al. MOLECULAR THERAPY
- Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome
- (2011) Guang-Hui Liu et al. NATURE
- Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells
- (2011) Olivia G Kelly et al. NATURE BIOTECHNOLOGY
- A more efficient method to generate integration-free human iPS cells
- (2011) Keisuke Okita et al. NATURE METHODS
- Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
- (2011) Naoki Yahata et al. PLoS One
- Brief Report: Phenotypic Rescue of Induced Pluripotent Stem Cell-Derived Motoneurons of a Spinal Muscular Atrophy Patient
- (2011) Tammy Chang et al. STEM CELLS
- Concise Review: Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: Progress Toward Safe Clinical Products
- (2011) Yunjoon Jung et al. STEM CELLS
- Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells
- (2011) Jessica Dias et al. STEM CELLS AND DEVELOPMENT
- Mesenchymal Stromal Cell Migration: Possibilities to Improve Cellular Therapy
- (2011) Marijke W. Maijenburg et al. STEM CELLS AND DEVELOPMENT
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Derivation of Endothelial Cells From Human Embryonic Stem Cells by Directed Differentiation
- (2010) Nicole M. Kane et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
- (2010) Maria C.N. Marchetto et al. CELL
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects
- (2010) Jinqiu Zhang et al. Cell Stem Cell
- Human embryonic stem cell−derived vascular progenitor cells capable of endothelial and smooth muscle cell function
- (2010) Katherine L. Hill et al. EXPERIMENTAL HEMATOLOGY
- Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine
- (2010) H. Lapillonne et al. HAEMATOLOGICA
- Roadblocks en route to the clinical application of induced pluripotent stem cells
- (2010) W. E. Lowry et al. JOURNAL OF CELL SCIENCE
- Transient activation ofc-MYCexpression is critical for efficient platelet generation from human induced pluripotent stem cells
- (2010) Naoya Takayama et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
- (2010) Z. Ni et al. JOURNAL OF VIROLOGY
- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
- (2010) Jason R. Spence et al. NATURE
- A nonviral minicircle vector for deriving human iPS cells
- (2010) Fangjun Jia et al. NATURE METHODS
- Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
- (2010) Aba Somers et al. STEM CELLS
- Enrichment of Human ESC-Derived Multipotent Mesenchymal Stem Cells with Immunosuppressive and Anti-Inflammatory Properties Capable to Protect Against Experimental Inflammatory Bowel Disease
- (2010) Laura Sánchez et al. STEM CELLS
- VEGF Induces Differentiation of Functional Endothelium From Human Embryonic Stem Cells
- (2009) Marilyn B. Nourse et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- In vitro differentiation of retinal ganglion-like cells from embryonic stem cell derived neural progenitors
- (2009) Balusamy Jagatha et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
- (2009) P. S. Woll et al. BLOOD
- Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
- (2009) Zhihua Song et al. CELL RESEARCH
- Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins
- (2009) Dohoon Kim et al. Cell Stem Cell
- Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones
- (2009) F. Timmermans et al. JOURNAL OF IMMUNOLOGY
- piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
- (2009) Knut Woltjen et al. NATURE
- Developing safe therapies from human pluripotent stem cells
- (2009) Melissa K Carpenter et al. NATURE BIOTECHNOLOGY
- Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
- (2009) Noemi FUSAKI et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells
- (2009) Su-Yi Tseng et al. Regenerative Medicine
- Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
- (2009) J. Yu et al. SCIENCE
- Long-Term Safety and Function of RPE from Human Embryonic Stem Cells in Preclinical Models of Macular Degeneration
- (2009) Bin Lu et al. STEM CELLS
- Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
- (2008) N. Takayama et al. BLOOD
- Biologic properties and enucleation of red blood cells from human embryonic stem cells
- (2008) S.-J. Lu et al. BLOOD
- Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
- (2008) Maria C.N. Marchetto et al. Cell Stem Cell
- Differentiation of Human Embryonic Stem Cells into Immunostimulatory Dendritic Cells under Feeder-Free Culture Conditions
- (2008) Z. Su et al. CLINICAL CANCER RESEARCH
- Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes
- (2008) Hesham Basma et al. GASTROENTEROLOGY
- Induced pluripotent stem cells from a spinal muscular atrophy patient
- (2008) Allison D. Ebert et al. NATURE
- Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
- (2008) Evert Kroon et al. NATURE BIOTECHNOLOGY
- Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
- (2008) Wolfgang Wagner et al. PLoS One
- Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
- (2008) J. T. Dimos et al. SCIENCE
- Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
- (2008) Sadhana Agarwal et al. STEM CELLS
- Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection
- (2008) Sriram Bandi et al. AIDS Research and Therapy
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search