iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery
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Title
iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery
Authors
Keywords
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Journal
ACTA PHARMACOLOGICA SINICA
Volume 34, Issue 6, Pages 765-776
Publisher
Springer Nature
Online
2013-04-22
DOI
10.1038/aps.2013.21
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Note: Only part of the references are listed.- Stress-mediated p38 activation promotes somatic cell reprogramming
- (2012) Xinxiu Xu et al. CELL RESEARCH
- Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
- (2012) Richard P. Davis et al. CIRCULATION
- Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation
- (2012) J. Fujikura et al. DIABETOLOGIA
- Generation of human induced pluripotent stem cells from urine samples
- (2012) Ting Zhou et al. Nature Protocols
- The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity
- (2012) Stefano Camnasio et al. NEUROBIOLOGY OF DISEASE
- Cure of ADPKD by Selection for Spontaneous Genetic Repair Events in Pkd1-Mutated iPS Cells
- (2012) Li-Tao Cheng et al. PLoS One
- Pathogenic Mutation of ALK2 Inhibits Induced Pluripotent Stem Cell Reprogramming and Maintenance: Mechanisms of Reprogramming and Strategy for Drug Identification
- (2012) Makoto Hamasaki et al. STEM CELLS
- An Elaborate Regulation of Mammalian Target of Rapamycin Activity Is Required for Somatic Cell Reprogramming Induced by Defined Transcription Factors
- (2012) Jing He et al. STEM CELLS AND DEVELOPMENT
- Glia: an emerging target for neurological disease therapy
- (2012) Akshata A Almad et al. Stem Cell Research & Therapy
- Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
- (2011) Taotao Chen et al. AGING CELL
- Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells
- (2011) Quan Wang et al. CELL RESEARCH
- Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
- (2011) Bernadett Papp et al. CELL RESEARCH
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells
- (2011) Ori Bar-Nur et al. Cell Stem Cell
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner
- (2011) Tao Wang et al. Cell Stem Cell
- UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
- (2011) Jin Zhang et al. EMBO JOURNAL
- Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
- (2011) Elena Matsa et al. EUROPEAN HEART JOURNAL
- Modeling familial Alzheimer's disease with induced pluripotent stem cells
- (2011) Takuya Yagi et al. HUMAN MOLECULAR GENETICS
- Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin
- (2011) Shiqiang Zhang et al. HUMAN MOLECULAR GENETICS
- Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation
- (2011) Atara Novak et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
- (2011) P. Seibler et al. JOURNAL OF NEUROSCIENCE
- Modelling schizophrenia using human induced pluripotent stem cells
- (2011) Kristen J. Brennand et al. NATURE
- Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
- (2011) Masayuki Yazawa et al. NATURE
- Modelling the long QT syndrome with induced pluripotent stem cells
- (2011) Ilanit Itzhaki et al. NATURE
- A functionally characterized test set of human induced pluripotent stem cells
- (2011) Gabriella L Boulting et al. NATURE BIOTECHNOLOGY
- Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts
- (2011) Sandra Varum et al. PLoS One
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
- (2011) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human pluripotent stem cells in drug discovery and predictive toxicology
- (2010) Delphine Laustriat et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells
- (2010) Toshihiro Kobayashi et al. CELL
- A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
- (2010) Maria C.N. Marchetto et al. CELL
- Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds
- (2010) Saiyong Zhu et al. Cell Stem Cell
- Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
- (2010) Achia Urbach et al. Cell Stem Cell
- Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA⋅TTC Triplet Repeat Instability
- (2010) Sherman Ku et al. Cell Stem Cell
- Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells
- (2010) Miguel Angel Esteban et al. Cell Stem Cell
- A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts
- (2010) Ronghui Li et al. Cell Stem Cell
- Activation of the ImprintedDlk1-Dio3Region Correlates with Pluripotency Levels of Mouse Stem Cells
- (2010) Lei Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome
- (2010) Jiayin Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
- (2010) S. Tamir Rashid et al. JOURNAL OF CLINICAL INVESTIGATION
- Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
- (2010) Matthias Stadtfeld et al. NATURE
- Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
- (2010) Xonia Carvajal-Vergara et al. NATURE
- L1 retrotransposition in neurons is modulated by MeCP2
- (2010) Alysson R. Muotri et al. NATURE
- Epigenetic memory in induced pluripotent stem cells
- (2010) K. Kim et al. NATURE
- Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
- (2010) Jose M Polo et al. NATURE BIOTECHNOLOGY
- Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
- (2010) Alessandra Moretti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
- (2010) Osahiko Tsuji et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes
- (2010) Stormy J. Chamberlain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
- (2009) Tomofumi Tanaka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oct4-Induced Pluripotency in Adult Neural Stem Cells
- (2009) Jeong Beom Kim et al. CELL
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors
- (2009) Frank Soldner et al. CELL
- A Small-Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
- (2009) Justin K. Ichida et al. Cell Stem Cell
- Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins
- (2009) Hongyan Zhou et al. Cell Stem Cell
- Repair of Acute Myocardial Infarction by Human Stemness Factors Induced Pluripotent Stem Cells
- (2009) Timothy J. Nelson et al. CIRCULATION
- Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells
- (2009) Limor Zwi et al. CIRCULATION
- Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
- (2009) Jianhua Zhang et al. CIRCULATION RESEARCH
- Multiple Mutations in Genetic Cardiovascular Disease
- (2009) Matthew Kelly et al. Circulation-Cardiovascular Genetics
- Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc
- (2009) Nimet Maherali et al. CURRENT BIOLOGY
- Senescence impairs successful reprogramming to pluripotent stem cells
- (2009) A. Banito et al. GENES & DEVELOPMENT
- The genetic basis of long QT and short QT syndromes: A mutation update
- (2009) Paula L. Hedley et al. HUMAN MUTATION
- Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
- (2009) Gabsang Lee et al. NATURE
- Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
- (2009) Hyenjong Hong et al. NATURE
- Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
- (2009) Ángel Raya et al. NATURE
- A chemical platform for improved induction of human iPSCs
- (2009) Tongxiang Lin et al. NATURE METHODS
- Generation of pluripotent stem cells from patients with type 1 diabetes
- (2009) R. Maehr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phenotypic correction of murine hemophilia A using an iPS cell-based therapy
- (2009) Dan Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
- (2009) C. A. Lyssiotis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
- (2009) Stefan R. Braam et al. Stem Cell Research
- Disease-Specific Induced Pluripotent Stem Cells
- (2008) In-Hyun Park et al. CELL
- Stem Cells and Drug Discovery: The Beginning of a New Era?
- (2008) Lee L. Rubin CELL
- A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells
- (2008) Yan Shi et al. Cell Stem Cell
- Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency
- (2008) Alexander Marson et al. Cell Stem Cell
- Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds
- (2008) Yan Shi et al. Cell Stem Cell
- Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors
- (2008) Wenlin Li et al. Cell Stem Cell
- Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells
- (2008) Christina Mauritz et al. CIRCULATION
- Spinal muscular atrophy
- (2008) Mitchell R Lunn et al. LANCET
- Induced pluripotent stem cells from a spinal muscular atrophy patient
- (2008) Allison D. Ebert et al. NATURE
- The ground state of embryonic stem cell self-renewal
- (2008) Qi-Long Ying et al. NATURE
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- (2008) Danwei Huangfu et al. NATURE BIOTECHNOLOGY
- Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
- (2008) Danwei Huangfu et al. NATURE BIOTECHNOLOGY
- Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
- (2008) M. Wernig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
- (2008) M. Chahrour et al. SCIENCE
- Induced Pluripotent Stem Cells Generated Without Viral Integration
- (2008) M. Stadtfeld et al. SCIENCE
- Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
- (2008) J. T. Dimos et al. SCIENCE
- Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
- (2008) Jose Silva et al. PLOS BIOLOGY
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