Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

(2014) Lisa Oestereich et al.   ANTIVIRAL RESEARCH

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

(2014) Gerrit Gehring et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Amine-Containing Molecules and the Induction of an Expanded Lysosomal Volume Phenotype: A Structure–Activity Relationship Study

(2014) Randall Logan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay

(2014) H. A. Elshabrawy et al.   JOURNAL OF VIROLOGY

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle

(2013) Yuan-Lung Cheng et al.   CLINICAL SCIENCE

A Mutation in the Ebola Virus Envelope Glycoprotein Restricts Viral Entry in a Host Species- and Cell-Type-Specific Manner

(2013) O. Martinez et al.   JOURNAL OF VIROLOGY

Multiple Cationic Amphiphiles Induce a Niemann-Pick C Phenotype and Inhibit Ebola Virus Entry and Infection

(2013) Charles J. Shoemaker et al.   PLoS One

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

(2012) Patrick Iversen et al.   Viruses-Basel

Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype

(2011) Elena Piccoli et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a Small-Molecule Entry Inhibitor for Filoviruses

(2011) A. Basu et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Quantitative analysis of particles, genomes and infectious particles in supernatants of haemorrhagic fever virus cell cultures

(2011) Manfred Weidmann et al.   Virology Journal

Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms

(2010) S. Mitterreiter et al.   JOURNAL OF NEUROSCIENCE

Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines

(2010) Michael A. Whitt   JOURNAL OF VIROLOGICAL METHODS

Biochemical and Structural Characterization of Cathepsin L-Processed Ebola Virus Glycoprotein: Implications for Viral Entry and Immunogenicity

(2010) C. L. Hood et al.   JOURNAL OF VIROLOGY

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology

(2009) G Morissette et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lysosomal degradation of membrane lipids

(2009) Thomas Kolter et al.   FEBS LETTERS

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity

(2009) Cristiano Salata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Primed Ebolavirus Glycoprotein (19-Kilodalton GP1,2): Sequence and Residues Critical for Host Cell Binding

(2009) D. Dube et al.   JOURNAL OF VIROLOGY

Amiodarone Alters Late Endosomes and Inhibits SARS Coronavirus Infection at a Post-Endosomal Level

(2008) Konrad Stadler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Amiodarone Inhibits Arterial Thrombus Formation and Tissue Factor Translation

(2008) A. Breitenstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE