Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients

(2014) I Roberts et al.   HEALTH TECHNOLOGY ASSESSMENT

Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages

(2013) Qun Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Functional characterization of a slow and tight-binding inhibitor of plasmin isolated from Russell's viper venom

(2013) An-Chun Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antifibrinolytic agents in current anaesthetic practice

(2013) E Ortmann et al.   BRITISH JOURNAL OF ANAESTHESIA

Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer

(2013) V Heinemann et al.   BRITISH JOURNAL OF CANCER

The plasminogen activation system: new targets in lung inflammation and remodeling

(2013) Michael Schuliga et al.   CURRENT OPINION IN PHARMACOLOGY

The promise of sulfated synthetic small molecules as modulators of glycosaminoglycan function

(2013) Umesh R Desai   Future Medicinal Chemistry

Comparison of Epsilon Aminocaproic Acid and Tranexamic Acid in Thoracic Aortic Surgery: Clinical Efficacy and Safety

(2013) Neeti Makhija et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions

(2013) Rafik Karaman et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing Inhibition

(2013) Preetpal Singh Sidhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of New Cyclic Plasmin Inhibitors with Excellent Potency and Selectivity

(2013) Sebastian M. Saupe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Fibrinolysis Inhibitor Discovered by Shape and Electrostatic Complementarity to the Drug Tranexamic Acid

(2013) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site

(2013) Rajesh Karuturi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sulfated Pentagalloylglucoside Is a Potent, Allosteric, and Selective Inhibitor of Factor XIa

(2013) Rami A. Al-Horani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into thrombin activatable fibrinolysis inhibitor function and regulation

(2013) J. H. Foley et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Alternatives to blood transfusion

(2013) Donat R Spahn et al.   LANCET

A Spider-Derived Kunitz-Type Serine Protease Inhibitor That Acts as a Plasmin Inhibitor and an Elastase Inhibitor

(2013) Hu Wan et al.   PLoS One

Gender Affects Skin Wound Healing in Plasminogen Deficient Mice

(2013) Birgitte Rønø et al.   PLoS One

The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake

(2013) Emma-Karin I. Millers et al.   PLoS One

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

(2013) James J. Valdés et al.   PLoS One

Interactions of heparin and a covalently-linked antithrombin-heparin complex with components of the fibrinolytic system

(2013) Ankush Chander et al.   THROMBOSIS AND HAEMOSTASIS

Diagnosis and treatment of acquired von Willebrand syndrome

(2013) Andreas Tiede   THROMBOSIS RESEARCH

Risk Factors for Hepatic Artery Thrombosis After Microsurgical Vascular Reconstruction in Liver Transplantation

(2013) S. Miyagi et al.   TRANSPLANTATION PROCEEDINGS

Activation of the anti-cancer agent upamostat by the mARC enzyme system

(2013) Danilo Froriep et al.   XENOBIOTICA

Cooperative Plasminogen Recruitment to the Surface of Streptococcus canis via M Protein and Enolase Enhances Bacterial Survival

(2013) M. Fulde et al.   mBio

Tranexamic acid: an important adjuvant in the treatment of melasma

(2013) Tsz Wah Tse et al.   Journal of Cosmetic Dermatology

The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure

(2012) I. T. N. Campos et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Effects of MDCO-2010, a Serine Protease Inhibitor, on Activated Clotting Time in Blood Obtained from Volunteers and Cardiac Surgical Patients

(2012) Heezoo Kim et al.   ANESTHESIA AND ANALGESIA

The urokinase plasminogen activator system in breast cancer invasion and metastasis

(2012) Linlin Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis

(2012) W. Wu et al.   BLOOD

Natural and Engineered Plasmin Inhibitors: Applications and Design Strategies

(2012) Joakim E. Swedberg et al.   CHEMBIOCHEM

Structure and function of invertebrate Kunitz serine protease inhibitors

(2012) Shiwanthi Ranasinghe et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor

(2012) D. Navaneetham et al.   JOURNAL OF BIOCHEMISTRY

Cell Surface Remodeling by Plasmin: A New Function for an Old Enzyme

(2012) Elena I. Deryugina et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors

(2012) Irene Lecker et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasmin as a proinflammatory cell activator

(2012) T. Syrovets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite 2 to Induce Inhibition

(2012) May H. Abdel Aziz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

(2012) Sebastian M. Saupe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead

(2012) Naoki Teno et al.   JOURNAL OF PEPTIDE SCIENCE

Coronary artery bypass grafting after aprotinin: Are we doing better?

(2012) Ziv Beckerman et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Putting the record straight on aprotinin as safe and effective: Results from a mixed treatment meta-analysis of trials of aprotinin

(2012) Neil Howell et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Crystal structure of the native plasminogen reveals an activation-resistant compact conformation

(2012) Y. XUE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antifibrinolytic Role of a Bee Venom Serine Protease Inhibitor That Acts as a Plasmin Inhibitor

(2012) Young Moo Choo et al.   PLoS One

Novel low molecular weight lignins as potential anti-emphysema agents: In vitro triple inhibitory activity against elastase, oxidation and inflammation

(2012) Bhawana Saluja et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Molecular cloning and antifibrinolytic activity of a serine protease inhibitor from bumblebee (Bombus terrestris) venom

(2012) Yuling Qiu et al.   TOXICON

Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia

(2012) John W. Chen et al.   JACC-Cardiovascular Imaging

The X-ray Crystal Structure of Full-Length Human Plasminogen

(2012) Ruby H.P. Law et al.   Cell Reports

Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study

(2011) Tomoki Nishiyama et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Nafamostat Mesilate Attenuates Postreperfusion Syndrome during Liver Transplantation

(2011) H.-G. Ryu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Identification of the site of binding of sulfated, low molecular weight lignins on thrombin

(2011) May H. Abdel Aziz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases

(2011) Brian L. Henry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The P2′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity

(2011) Moh'd A. Salameh et al.   BIOCHEMICAL JOURNAL

Plasmin Substrate Binding Site Cooperativity Guides the Design of Potent Peptide Aldehyde Inhibitors

(2011) Joakim E. Swedberg et al.   BIOCHEMISTRY

Identification of novel plasmin inhibitors possessing nitrile moiety as warhead

(2011) Naoki Teno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How I treat the acquired von Willebrand syndrome

(2011) A. Tiede et al.   BLOOD

Managing clotting

(2011) Roman M. Sniecinski et al.   Current Opinion in Anesthesiology

Nafamostat Mesilate as an Anticoagulant during Continuous Veno-Venous Hemodialysis: A Three-Year Retrospective Cohort Study

(2011) Yukio Maruyama et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Contribution of Conserved Lysine Residues in the α2-Antiplasmin C Terminus to Plasmin Binding and Inhibition

(2011) Bernadine G. C. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator

(2011) Paul Y. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing Nonsaccharide, Allosteric Activators of Antithrombin for Accelerated Inhibition of Factor Xa

(2011) Rami A. Al-Horani et al.   JOURNAL OF MEDICINAL CHEMISTRY

A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial)

(2011) Paula M. Bokesch et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b+/F4/80+ myeloid cell recruitment

(2011) M Ishihara et al.   LEUKEMIA

Nafamostat Mesilate for Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

(2011) Kyo-Sang Yoo et al.   PANCREAS

Plasmin Inhibitors Prevent Leukocyte Accumulation and Remodeling Events in the Postischemic Microvasculature

(2011) Christoph A. Reichel et al.   PLoS One

Multidrug strategies are effective in the treatment of severe experimental pancreatitis

(2011) Jens Werner et al.   SURGERY

Antifibrinolytics in women with menorrhagia

(2011) Claire S. Philipp   THROMBOSIS RESEARCH

High-Dose Tranexamic Acid Is Associated with Nonischemic Clinical Seizures in Cardiac Surgical Patients

(2010) John M. Murkin et al.   ANESTHESIA AND ANALGESIA

Plasmin Triggers Chemotaxis of Monocyte-Derived Dendritic Cells Through an Akt2-Dependent Pathway and Promotes a T-Helper Type-1 Response

(2010) Xuehua Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding

(2010) In Seok Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Noncovalent Interaction of α2-Antiplasmin with Fibrin(ogen): Localization of α2-Antiplasmin-Binding Sites

(2010) Galina Tsurupa et al.   BIOCHEMISTRY

A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity

(2010) Renata M.O. Watanabe et al.   BIOCHIMIE

Biologic protease inhibitors as novel therapeutic agents

(2010) Christopher J. Scott et al.   BIOCHIMIE

Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity

(2010) Renata M.O. Watanabe et al.   BIOCHIMIE

Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells

(2010) Tsuyoshi Fukushima et al.   CANCER SCIENCE

Thrombolytics and Myocardial Infarction

(2010) Vijayalakshmi Kunadian et al.   Cardiovascular Therapeutics

The plasmin–antiplasmin system: structural and functional aspects

(2010) Johann Schaller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Re-evaluation of the role of antifibrinolytic therapy with lysine analogs during cardiac surgery in the post aprotinin era

(2010) Andreas Koster et al.   Current Opinion in Anesthesiology

Inhibition of cell invasion and protease activity by cholesterol sulfate

(2010) Hanako Nakae et al.   FERTILITY AND STERILITY

Engineering Kunitz Domain 1 (KD1) of Human Tissue Factor Pathway Inhibitor-2 to Selectively Inhibit Fibrinolysis

(2010) Madhu S. Bajaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel synthetic serine protease inhibitor CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model

(2010) Gábor Szabó et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Role of plasminogen in macrophage accumulation during liver repair

(2010) Naoyuki Kawao et al.   THROMBOSIS RESEARCH

Drug development from Australian elapid snake venoms and the Venomics pipeline of candidates for haemostasis: Textilinin-1 (Q8008), Haempatch™ (Q8009) and CoVase™ (V0801)

(2010) Stephen T.H. Earl et al.   TOXICON

Efficacy of tranexamic acid in sporadic idiopathic bradykinin angioedema

(2009) A. Du-Thanh et al.   ALLERGY

Noninfectious Serious Hazards of Transfusion

(2009) Jeanne E. Hendrickson et al.   ANESTHESIA AND ANALGESIA

Textilinin-1, an alternative anti-bleeding agent to aprotinin: Importance of plasmin inhibition in controlling blood loss

(2009) Simone M. Flight et al.   BRITISH JOURNAL OF HAEMATOLOGY

Guidelines for the diagnosis and management of disseminated intravascular coagulation

(2009) M Levi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bleeding in Liver Surgery: Prevention and Treatment

(2009) Edris M. Alkozai et al.   Clinics in Liver Disease

Structure and function of invertebrate Kazal-type serine proteinase inhibitors

(2009) Vichien Rimphanitchayakit et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

(2009) Emma-Karin I. Millers et al.   FEBS Journal

Inhibition of proteases involved in embryo implantation by cholesterol sulfate

(2009) M. Koizumi et al.   HUMAN REPRODUCTION

A Kazal-type serine proteinase inhibitor from chicken liver (clTI-1)

(2009) Agnieszka Kubiak et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Plasminogen Enhances Neuritogenesis on Laminin-1

(2009) A. Gutierrez-Fernandez et al.   JOURNAL OF NEUROSCIENCE

Effects of novel synthetic serine protease inhibitors on postoperative blood loss, coagulation parameters, and vascular relaxation after cardiac surgery

(2009) Gábor Szabó et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Structure of a serine protease poised to resynthesize a peptide bond

(2009) E. Zakharova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pivotal Role of Thrombin in Cancer Biology and Tumorigenesis

(2009) Kristen Snyder et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Sulfated, low-molecular-weight lignins are potent inhibitors of plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies

(2009) Brian Henry et al.   THROMBOSIS AND HAEMOSTASIS

Activity-based costs of blood transfusions in surgical patients at four hospitals

(2009) Aryeh Shander et al.   TRANSFUSION

CU-2010—A Novel Small Molecule Protease Inhibitor with Antifibrinolytic and Anticoagulant Properties

(2008) Wulf Dietrich et al.   ANESTHESIOLOGY

Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids

(2008) Brian L Henry et al.   BLOOD COAGULATION & FIBRINOLYSIS

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery

(2008) Andreas Lehmann   EXPERT OPINION ON BIOLOGICAL THERAPY

Systemic AL amyloidosis with disseminated intravascular coagulation associated with hyperfibrinolysis

(2008) Toru Takahashi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Macrocyclic inhibitors for the serine protease plasmin

(2008) Fengtian Xue et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Aprotinin during Coronary-Artery Bypass Grafting and Risk of Death

(2008) Sebastian Schneeweiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Effect of Aprotinin on Outcome after Coronary-Artery Bypass Grafting

(2008) Andrew D. Shaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure and activity of plasmin and other direct thrombolytic agents

(2008) Valery Novokhatny   THROMBOSIS RESEARCH

Pharmacologic methods to reduce perioperative bleeding

(2008) Jerrold H. Levy   TRANSFUSION