Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials
出版年份 2020 全文链接
标题
Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 15, Pages 5224
出版商
MDPI AG
发表日期
2020-07-23
DOI
10.3390/ijms21155224
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China
- (2020) Jin-jin Zhang et al. ALLERGY
- The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer
- (2020) Sundy N.Y. Yang et al. ANTIVIRAL RESEARCH
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics
- (2020) David Gurwitz DRUG DEVELOPMENT RESEARCH
- Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus
- (2020) Weicheng Liang et al. GUT
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China
- (2020) Dawei Wang et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
- (2020) Ning Tang et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Baricitinib as potential treatment for 2019-nCoV acute respiratory disease
- (2020) Peter Richardson et al. LANCET
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- (2020) Roujian Lu et al. LANCET
- An interactive web-based dashboard to track COVID-19 in real time
- (2020) Ensheng Dong et al. LANCET INFECTIOUS DISEASES
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- COVID-19 and the cardiovascular system
- (2020) Ying-Ying Zheng et al. Nature Reviews Cardiology
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
- (2020) Jimin Xu et al. ACS Infectious Diseases
- Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods
- (2020) Canrong Wu et al. Acta Pharmaceutica Sinica B
- Amiodarone: A Comprehensive Guide for Clinicians
- (2020) David Hamilton et al. American Journal of Cardiovascular Drugs
- Can spironolactone be used to prevent COVID-19-induced acute respiratory distress syndrome in patients with hypertension?
- (2020) Flávio A. Cadegiani AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs
- (2020) Sangeun Jeon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19
- (2020) Markus Hoffmann et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Convalescent plasma in Covid-19: Possible mechanisms of action
- (2020) Manuel Rojas et al. AUTOIMMUNITY REVIEWS
- Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
- (2020) Vanessa Monteil et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Functional exhaustion of antiviral lymphocytes in COVID-19 patients
- (2020) Meijuan Zheng et al. Cellular & Molecular Immunology
- Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China
- (2020) Yan Deng et al. CHINESE MEDICAL JOURNAL
- Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
- (2020) Mahmoud Gheblawi et al. CIRCULATION RESEARCH
- The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China
- (2020) Wen Zhang et al. CLINICAL IMMUNOLOGY
- Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study
- (2020) Andrea Giacomelli et al. CLINICAL INFECTIOUS DISEASES
- Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China
- (2020) Chuan Qin et al. CLINICAL INFECTIOUS DISEASES
- Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study
- (2020) N. Lian et al. CLINICAL MICROBIOLOGY AND INFECTION
- COVID-19 treatment by repurposing drugs until the vaccine is in sight
- (2020) Mrudula Phadke et al. DRUG DEVELOPMENT RESEARCH
- Repurposing chlorpromazine to treat COVID-19: The reCoVery study
- (2020) M. Plaze et al. ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
- Pulmonary embolism in patients with Covid-19 pneumonia
- (2020) Florian Bompard et al. EUROPEAN RESPIRATORY JOURNAL
- Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review
- (2020) Nicholas E. Ingraham et al. EUROPEAN RESPIRATORY JOURNAL
- High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study
- (2020) Julie Helms et al. INTENSIVE CARE MEDICINE
- Camostat mesilate therapy for COVID-19
- (2020) Yoshiharu Uno Internal and Emergency Medicine
- Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein
- (2020) Naveen Vankadari INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
- (2020) Christian A. Devaux et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine
- (2020) Zahra Sahraei et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial
- (2020) Philippe Gautret et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Three cases of treatment with Nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy
- (2020) Sukbin Jang et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?
- (2020) Samir Jawhara INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Convalescent Plasma to Treat COVID-19
- (2020) John D. Roback et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
- (2020) Chenguang Shen et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State
- (2020) Eli S. Rosenberg et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
- (2020) James M. Sanders et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression
- (2020) Dan Zhou et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy
- (2020) Angela Ceribelli et al. JOURNAL OF AUTOIMMUNITY
- The convalescent sera option for containing COVID-19
- (2020) Arturo Casadevall et al. JOURNAL OF CLINICAL INVESTIGATION
- Deployment of convalescent plasma for the prevention and treatment of COVID-19
- (2020) Evan M. Bloch et al. JOURNAL OF CLINICAL INVESTIGATION
- Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact
- (2020) Fabrizio Cantini et al. JOURNAL OF INFECTION
- Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19
- (2020) Zhen Zhu et al. JOURNAL OF INFECTION
- Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19
- (2020) Yun Xie et al. JOURNAL OF INFECTION
- Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study
- (2020) Lisi Deng et al. JOURNAL OF INFECTION
- Treatment with convalescent plasma for COVID-19 patients in Wuhan, China
- (2020) Mingxiang Ye et al. JOURNAL OF MEDICAL VIROLOGY
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated
- (2020) Carlos Gustavo Wambier et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
- (2020) Behnood Bikdeli et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cutaneous manifestations in COVID‐19: a first perspective
- (2020) S. Recalcati JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- ISTH interim guidance on recognition and management of coagulopathy in COVID‐19: A Comment
- (2020) Christopher D. Barrett et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia
- (2020) Songping Cui et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome
- (2020) Marco Ranucci et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Acute limb ischemia in patients with COVID-19 pneumonia
- (2020) Raffaello Bellosta et al. JOURNAL OF VASCULAR SURGERY
- Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
- (2020) Fei Zhou et al. LANCET
- COVID-19: consider cytokine storm syndromes and immunosuppression
- (2020) Puja Mehta et al. LANCET
- A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
- (2020) Markus Hoffmann et al. MOLECULAR CELL
- Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
- (2020) Giuseppe Mancia et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
- (2020) Harmony R. Reynolds et al. NEW ENGLAND JOURNAL OF MEDICINE
- ST-Segment Elevation in Patients with Covid-19 — A Case Series
- (2020) Sripal Bangalore et al. NEW ENGLAND JOURNAL OF MEDICINE
- Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
- (2020) Muthiah Vaduganathan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
- (2020) Joshua Geleris et al. NEW ENGLAND JOURNAL OF MEDICINE
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
- (2020) Thomas J. Oxley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
- (2020) Tianxiao Liu et al. PHARMACOLOGY & THERAPEUTICS
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effectiveness of convalescent plasma therapy in severe COVID-19 patients
- (2020) Kai Duan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the RNA-dependent RNA polymerase from COVID-19 virus
- (2020) Yan Gao et al. SCIENCE
- Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
- (2020) Linlin Zhang et al. SCIENCE
- Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses
- (2020) Shibo Jiang et al. TRENDS IN IMMUNOLOGY
- Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection
- (2020) David S. Fedson et al. mBio
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France
- (2020) Matthieu Million et al. Travel Medicine and Infectious Disease
- Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study
- (2020) Philippe Gautret et al. Travel Medicine and Infectious Disease
- Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin
- (2020) José Millán-Oñate et al. Annals of Clinical Microbiology and Antimicrobials
- Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial
- (2020) Wei Tang et al. BMJ-British Medical Journal
- Amiodarone as a possible therapy for coronavirus infection
- (2020) Alberto Aimo et al. European Journal of Preventive Cardiology
- Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
- (2020) Chaomin Wu et al. JAMA Internal Medicine
- Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China
- (2020) Ling Mao et al. JAMA Neurology
- Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China
- (2020) Ping Wu et al. JAMA Ophthalmology
- Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
- (2020) Lei Fang et al. Lancet Respiratory Medicine
- Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
- (2020) Xin Zou et al. Frontiers of Medicine
- Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
- (2020) Jia Liu et al. Cell Discovery
- High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019
- (2020) Wei Cao et al. Open Forum Infectious Diseases
- Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19
- (2020) Sebastiano Bruno Solerte et al. ACTA DIABETOLOGICA
- The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
- (2020) Leon Caly et al. ANTIVIRAL RESEARCH
- Reply to Gautret et al: hydroxychloroquine sulfate and azithromycin for COVID-19: what is the evidence and what are the risks?
- (2020) Julian D Machiels et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19
- (2020) Ling Li et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Effects of ARBs, ACEis, and Statins on Clinical Outcomes of COVID-19 Infection Among Nursing Home Residents
- (2020) Anton De Spiegeleer et al. Journal of the American Medical Directors Association
- No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection
- (2020) J.M. Molina et al. MEDECINE ET MALADIES INFECTIEUSES
- Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
- (2020) Sai Kiran S.S. Pindiprolu et al. MEDICAL HYPOTHESES
- A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19
- (2020) David R. Boulware et al. NEW ENGLAND JOURNAL OF MEDICINE
- Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection
- (2020) Roberto Maggio et al. PHARMACOLOGICAL RESEARCH
- Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility
- (2020) Hong-Long Ji et al. PHYSIOLOGICAL REVIEWS
- Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
- (2020) Johanna Hansen et al. SCIENCE
- Incidence of thrombotic complications in critically ill ICU patients with COVID-19
- (2020) F.A. Klok et al. THROMBOSIS RESEARCH
- Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels
- (2020) P. Demelo-Rodríguez et al. THROMBOSIS RESEARCH
- Coagulation abnormalities and thrombosis in patients with COVID-19
- (2020) Marcel Levi et al. Lancet Haematology
- Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
- (2020) Mayla Gabriela Silva Borba et al. JAMA Network Open
- TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection
- (2019) Naoko Iwata-Yoshikawa et al. JOURNAL OF VIROLOGY
- Arbidol and other Low Molecular Weight Drugs That Inhibit Lassa and Ebola Viruses
- (2019) C. E. Hulseberg et al. JOURNAL OF VIROLOGY
- Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells
- (2019) Huimin Zou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process
- (2019) Dat Huu Tran et al. JOURNAL OF ANTIBIOTICS
- The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication
- (2019) Morgan R. Herod et al. JOURNAL OF GENERAL VIROLOGY
- Antimalarial activity of primaquine operates via a two-step biochemical relay
- (2019) Grazia Camarda et al. Nature Communications
- Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses
- (2019) Chunfeng Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial
- (2019) Morihisa Hirota et al. JOURNAL OF GASTROENTEROLOGY
- A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC)
- (2019) Mitchell L. Ramsey et al. Trials
- Lipophilic statins inhibit Zika virus production in Vero cells
- (2019) Erica Españo et al. Scientific Reports
- Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib
- (2019) Elena Maria Elli et al. Frontiers in Oncology
- Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells
- (2019) Kim et al. Biomolecules
- Classics in Chemical Neuroscience: Chlorpromazine
- (2018) Debra Boyd-Kimball et al. ACS Chemical Neuroscience
- Niclosamide: Beyond an antihelminthic drug
- (2018) Wei Chen et al. CELLULAR SIGNALLING
- Hydroxychloroquine: An old drug with new relevance
- (2018) E. A. SHIPPEY et al. CLEVELAND CLINIC JOURNAL OF MEDICINE
- Drugs in Development for Malaria
- (2018) Elizabeth A. Ashley et al. DRUGS
- Antiviral activity of arbidol hydrochloride against herpes simplex virus I in vitro and in vivo
- (2018) Min-ke Li et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Adjunctive therapy with azithromycin for moderate and severe acute respiratory distress syndrome: a retrospective, propensity score-matching analysis of prospectively collected data at a single center
- (2018) Kodai Kawamura et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses
- (2018) Jan Haviernik et al. Viruses-Basel
- Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing
- (2018) Punya Shrivastava-Ranjan et al. mBio
- Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope
- (2018) Romulo L. S. Neris et al. Scientific Reports
- The Antiviral Drug Arbidol Inhibits Zika Virus
- (2018) Susan L. Fink et al. Scientific Reports
- Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations
- (2017) Andy Crump JOURNAL OF ANTIBIOTICS
- Doxycycline as an anti-inflammatory agent: updates in dermatology
- (2017) M. Henehan et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion
- (2017) Judith M. Phillips et al. JOURNAL OF VIROLOGY
- PharmGKB summary
- (2017) Alison E. Fohner et al. Pharmacogenetics and Genomics
- Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study
- (2017) Kodai Kawamura et al. BMC Pulmonary Medicine
- A reappraisal of the mucoactive activity and clinical efficacy of bromhexine
- (2017) Alessandro Zanasi et al. MULTIDISCIPLINARY RESPIRATORY MEDICINE
- Discovery and Development of Calcium Channel Blockers
- (2017) Théophile Godfraind Frontiers in Pharmacology
- Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay
- (2016) Mizuki Yamamoto et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Investigational hemagglutinin-targeted influenza virus inhibitors
- (2016) Li-Yan Zeng et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Heparin and anticoagulation
- (2016) Robert J Linhardt Frontiers in Bioscience-Landmark
- Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX
- (2016) I. Assunção-Miranda et al. JOURNAL OF APPLIED MICROBIOLOGY
- Use of Antipsychotics for the Treatment of Behavioral Symptoms of Dementia
- (2016) H. Karl Greenblatt et al. JOURNAL OF CLINICAL PHARMACOLOGY
- The Synthetic Antiviral Drug Arbidol Inhibits Globally Prevalent Pathogenic Viruses
- (2016) Eve-Isabelle Pécheur et al. JOURNAL OF VIROLOGY
- The anti-dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression
- (2016) Owen Lloyd Bryan-Marrugo et al. Molecular Medicine Reports
- Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision)
- (2016) Michael F. Marmor et al. OPHTHALMOLOGY
- Tetrandrine – A molecule of wide bioactivity
- (2016) N. Bhagya et al. PHYTOCHEMISTRY
- Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol
- (2016) Rameshwar U. Kadam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Zika virus cell tropism in the developing human brain and inhibition by azithromycin
- (2016) Hanna Retallack et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-inflammatory and immunomodulatory effects of antibiotics and their use in dermatology
- (2016) Bhushan Madke et al. INDIAN JOURNAL OF DERMATOLOGY
- Prescribing azithromycin
- (2015) Brendan K McMullan et al. Australian Prescriber
- Nafamostat Mesilate Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production
- (2015) Min-Woong Kang et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Ruxolitinib versus Standard Therapy for the Treatment of Polycythemia Vera
- (2015) Alessandro M. Vannucchi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
- (2015) Yasuteru Sakurai et al. SCIENCE
- Statins May Decrease the Fatality Rate of Middle East Respiratory Syndrome Infection: FIG 1
- (2015) Shu Yuan mBio
- Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
- (2015) Wahyu N. Wulan et al. Frontiers in Microbiology
- Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process
- (2015) Cristiano Salata et al. Pathogens and Disease
- Evaluation of Ebola Virus Inhibitors for Drug Repurposing
- (2015) Peter B. Madrid et al. ACS Infectious Diseases
- Arbidol as a broad-spectrum antiviral: An update
- (2014) Julie Blaising et al. ANTIVIRAL RESEARCH
- The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry
- (2014) Gerrit Gehring et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis
- (2014) John Mair-Jenkins et al. JOURNAL OF INFECTIOUS DISEASES
- An Investigational Antiviral Drug, DAS181, Effectively Inhibits Replication of Zoonotic Influenza A Virus Subtype H7N9 and Protects Mice From Lethality
- (2014) Henju Marjuki et al. JOURNAL OF INFECTIOUS DISEASES
- Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, for the Treatment of Rheumatoid Arthritis in Open-label, Longterm Extension Studies
- (2014) J. Wollenhaupt et al. JOURNAL OF RHEUMATOLOGY
- Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells
- (2014) A. Milewska et al. JOURNAL OF VIROLOGY
- Recent Advances on Plasmin Inhibitors for the Treatment of Fibrinolysis-Related Disorders
- (2014) Rami A. Al-Horani et al. MEDICINAL RESEARCH REVIEWS
- The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis
- (2014) J. M. Lucas et al. Cancer Discovery
- Meta-Analysis of the Adverse Effects of Long-Term Azithromycin Use in Patients with Chronic Lung Diseases
- (2013) Hui Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Arbidol inhibits viral entry by interfering with clathrin-dependent trafficking
- (2013) Julie Blaising et al. ANTIVIRAL RESEARCH
- Inhibitory effect of doxycycline against dengue virus replication in vitro
- (2013) Hussin A. Rothan et al. ARCHIVES OF VIROLOGY
- Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
- (2013) Nianshuang Wang et al. CELL RESEARCH
- Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle
- (2013) Yuan-Lung Cheng et al. CLINICAL SCIENCE
- Hemozoin and antimalarial drug discovery
- (2013) Kim Y Fong et al. Future Medicinal Chemistry
- Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis
- (2013) Josje Altenburg et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Oseltamivir resistance during treatment of H7N9 infection
- (2013) Alan J Hay et al. LANCET
- Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
- (2013) V. Stalin Raj et al. NATURE
- Imbalance Between Pulmonary Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Activity in Acute Respiratory Distress Syndrome
- (2013) Roelie M. Wösten-van Asperen et al. Pediatric Critical Care Medicine
- Practical management of patients with myelofibrosis receiving ruxolitinib
- (2013) Claire Harrison et al. Expert Review of Hematology
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- (2012) Kylie M. Wagstaff et al. BIOCHEMICAL JOURNAL
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- (2012) George R. Stark et al. IMMUNITY
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- (2012) Jennifer L. McKimm-Breschkin Influenza and Other Respiratory Viruses
- Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry
- (2012) M. Kawase et al. JOURNAL OF VIROLOGY
- Macrolide Therapy in Respiratory Viral Infections
- (2012) Jin-Young Min et al. MEDIATORS OF INFLAMMATION
- Ruxolitinib
- (2012) Ruben A. Mesa et al. NATURE REVIEWS DRUG DISCOVERY
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- (2012) Jing-Xuan Pan et al. Chinese Journal of Cancer
- Linagliptin
- (2011) Lesley J. Scott DRUGS
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- (2011) Yukio Maruyama et al. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
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- (2011) Aitana Braza-Boïls et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol
- (2011) Elodie Teissier et al. PLoS One
- Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans
- (2011) Jianshe Lang et al. PLoS One
- Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature
- (2010) Michael O. Griffin et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Azithromycin Alters Macrophage Phenotype and Pulmonary Compartmentalization during Lung Infection with Pseudomonas
- (2010) D. J. Feola et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Azithromycin induces anti-viral responses in bronchial epithelial cells
- (2010) V. Gielen et al. EUROPEAN RESPIRATORY JOURNAL
- Up-Regulation of the Inflammatory Response by Ovariectomy in Collagen-Induced Arthritis. Effects of Tin Protoporphyrin IX
- (2010) Lidia Ibáñez et al. INFLAMMATION
- A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo
- (2010) Anne Moscona et al. JOURNAL OF INFECTIOUS DISEASES
- DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues
- (2009) R. W. Y. Chan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis
- (2009) Gallen B. Triana-Baltzer et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease
- (2009) K. Coote et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine fromStephaniae tetrandrae
- (2009) Lijin Zhang et al. JOURNAL OF SEPARATION SCIENCE
- An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
- (2009) S. McCavera et al. MOLECULAR PHARMACOLOGY
- The spike protein of SARS-CoV — a target for vaccine and therapeutic development
- (2009) Lanying Du et al. NATURE REVIEWS MICROBIOLOGY
- Inhibition of Neuraminidase Inhibitor-Resistant Influenza Virus by DAS181, a Novel Sialidase Fusion Protein
- (2009) Gallen B. Triana-Baltzer et al. PLoS One
- Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
- (2009) S. Belouzard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Macrolides for the treatment of severe respiratory illness caused by novel H1N1 swine influenza viral strains
- (2009) Jesus F. Bermejo-Martin et al. Journal of Infection in Developing Countries
- Amiodarone Alters Late Endosomes and Inhibits SARS Coronavirus Infection at a Post-Endosomal Level
- (2008) Konrad Stadler et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.
- (2008) Bijan Zakeri et al. Biochemistry and Cell Biology
- Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension
- (2008) Ai Maekawa et al. JOURNAL OF HYPERTENSION
- Mouse Hepatitis Virus Type 2 Enters Cells through a Clathrin-Mediated Endocytic Pathway Independent of Eps15
- (2008) Y. Pu et al. JOURNAL OF VIROLOGY
- The anti-inflammatory effects of heparin and related compounds
- (2007) Edward Young THROMBOSIS RESEARCH
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