Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
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Title
Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence
Authors
Keywords
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Journal
ENDOCRINE-RELATED CANCER
Volume 23, Issue 12, Pages T179-T197
Publisher
Bioscientifica
Online
2016-11-01
DOI
10.1530/erc-16-0422
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Note: Only part of the references are listed.- AR-V7 Transcripts in Whole Blood RNA of Patients with Metastatic Castration Resistant Prostate Cancer Correlate with Response to Abiraterone Acetate
- (2017) Tilman Todenhöfer et al. JOURNAL OF UROLOGY
- Association Between Androgen Deprivation Therapy and Risk of Dementia
- (2017) Kevin T. Nead et al. JAMA Oncology
- EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor
- (2016) Eva De Mol et al. ACS Chemical Biology
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Targeting Androgen Receptor Activation Function-1 with EPI to Overcome Resistance Mechanisms in Castration-Resistant Prostate Cancer
- (2016) Y. C. Yang et al. CLINICAL CANCER RESEARCH
- Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer
- (2016) Jonathan Welti et al. EUROPEAN UROLOGY
- Recent progress in the development of protein–protein interaction inhibitors targeting androgen receptor–coactivator binding in prostate cancer
- (2016) Eric Biron et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- A Whole Blood Assay for AR-V7 and ARv567es in Patients with Prostate Cancer
- (2016) Xichun Liu et al. JOURNAL OF UROLOGY
- BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer
- (2016) I. A. Asangani et al. MOLECULAR CANCER RESEARCH
- A community-based model of rapid autopsy in end-stage cancer patients
- (2016) Kathryn Alsop et al. NATURE BIOTECHNOLOGY
- Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
- (2016) Akash Kumar et al. NATURE MEDICINE
- Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
- (2016) Himisha Beltran et al. NATURE MEDICINE
- ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer
- (2016) Junjian Wang et al. NATURE MEDICINE
- FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression
- (2016) J C Zhao et al. ONCOGENE
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Galeterone for the treatment of advanced prostate cancer: the evidence to date
- (2016) Emmanuel Antonarakis et al. Drug Design Development and Therapy
- A concise review of testosterone and bone health
- (2016) Nur Vaizura Mohamad et al. Clinical Interventions in Aging
- Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer
- (2016) Christopher Foley et al. Hormones & Cancer
- Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer
- (2016) Alexander W. Wyatt et al. JAMA Oncology
- Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
- (2015) Jeffrey L. Gustafson et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Lethal Prostate Cancer
- (2015) Samuel J. Vidal et al. CANCER CELL
- Androgen Receptor Splice Variants Dimerize to Transactivate Target Genes
- (2015) D. Xu et al. CANCER RESEARCH
- miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
- (2015) X.-B. Shi et al. CANCER RESEARCH
- Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation
- (2015) D. E. Spratt et al. CANCER RESEARCH
- Integrative Clinical Genomics of Advanced Prostate Cancer
- (2015) Dan Robinson et al. CELL
- The Molecular Taxonomy of Primary Prostate Cancer
- (2015) Adam Abeshouse et al. CELL
- Growth factors mediated cell signalling in prostate cancer progression: Implications in discovery of anti-prostate cancer agents
- (2015) Gaurav Joshi et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth
- (2015) Y. Yamamoto et al. CLINICAL CANCER RESEARCH
- Androgen Receptor Gene Aberrations in Circulating Cell-Free DNA: Biomarkers of Therapeutic Resistance in Castration-Resistant Prostate Cancer
- (2015) A. A. Azad et al. CLINICAL CANCER RESEARCH
- GATA2 deficiency
- (2015) Amy P. Hsu et al. Current Opinion in Allergy and Clinical Immunology
- Targeting the adaptive molecular landscape of castration-resistant prostate cancer
- (2015) A. W. Wyatt et al. EMBO Molecular Medicine
- Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure
- (2015) R. Pagliarini et al. EMBO REPORTS
- Efficacy of Cabazitaxel in Castration-resistant Prostate Cancer Is Independent of the Presence of AR-V7 in Circulating Tumor Cells
- (2015) Wendy Onstenk et al. EUROPEAN UROLOGY
- Molecular Characterization of Enzalutamide-treated Bone Metastatic Castration-resistant Prostate Cancer
- (2015) Eleni Efstathiou et al. EUROPEAN UROLOGY
- Discovery and Development of Galeterone (TOK-001 or VN/124-1) for the Treatment of All Stages of Prostate Cancer
- (2015) Vincent C. O. Njar et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Cistrome and Gene Signature of Androgen Receptor Splice Variants in Castration Resistant Prostate Cancer Cells
- (2015) Ji Lu et al. JOURNAL OF UROLOGY
- The evolutionary history of lethal metastatic prostate cancer
- (2015) Gunes Gundem et al. NATURE
- Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies
- (2015) Siu Chiu Chan et al. NUCLEIC ACIDS RESEARCH
- Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition
- (2015) Chengfei Liu et al. PROSTATE
- Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: Results from a pilot clinical study
- (2015) M. T. Schweizer et al. Science Translational Medicine
- Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy
- (2015) Daniel O’Neill et al. Oncotarget
- Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo
- (2015) Andrew K. Kwegyir-Afful et al. Oncotarget
- EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer
- (2015) Lucas J. Brand et al. Oncotarget
- The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7
- (2015) Jacqueline Stockley et al. Scientific Reports
- Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients With Metastatic Castration-Resistant Prostate Cancer
- (2015) Emmanuel S. Antonarakis et al. JAMA Oncology
- Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors
- (2015) Joanna L Gillis et al. Oncotarget
- GATA2 as a potential metastasis-driving gene in prostate cancer
- (2015) Yan Ting Chiang et al. Oncotarget
- Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
- (2015) Bo Cao et al. Oncotarget
- Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
- (2015) Anu-Maarit Moilanen et al. Scientific Reports
- AR Variant ARv567es Induces Carcinogenesis in a Novel Transgenic Mouse Model of Prostate Cancer
- (2015) Gang Liu et al. NEOPLASIA
- Abstract 5066: Matriptase mediated signaling in breast cancer.
- (2014) Gina L. Zoratti et al. CANCER RESEARCH
- Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
- (2014) C. Geng et al. CANCER RESEARCH
- Organoid Cultures Derived from Patients with Advanced Prostate Cancer
- (2014) Dong Gao et al. CELL
- Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer
- (2014) Z. Yu et al. CLINICAL CANCER RESEARCH
- Galeterone Prevents Androgen Receptor Binding to Chromatin and Enhances Degradation of Mutant Androgen Receptor
- (2014) Z. Yu et al. CLINICAL CANCER RESEARCH
- Niclosamide Inhibits Androgen Receptor Variants Expression and Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer
- (2014) C. Liu et al. CLINICAL CANCER RESEARCH
- Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors
- (2014) E. J. Chen et al. CLINICAL CANCER RESEARCH
- Androgen biosynthesis in castration-resistant prostate cancer
- (2014) Trevor M Penning ENDOCRINE-RELATED CANCER
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Selectively Targeting the DNA-binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer
- (2014) Kush Dalal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Androgen deprivation–induced NCoA2 promotes metastatic and castration-resistant prostate cancer
- (2014) Jun Qin et al. JOURNAL OF CLINICAL INVESTIGATION
- Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor
- (2014) Huifang Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial
- (2014) Karim Fizazi et al. LANCET ONCOLOGY
- N-terminal targeting of androgen receptor variant enhances response of castration resistant prostate cancer to taxane chemotherapy
- (2014) Sarah K. Martin et al. Molecular Oncology
- Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
- (2014) Irfan A. Asangani et al. NATURE
- AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
- (2014) Emmanuel S. Antonarakis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
- (2014) Tomasz M. Beer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Proteomic-Coupled-Network Analysis of T877A-Androgen Receptor Interactomes Can Predict Clinical Prostate Cancer Outcomes between White (Non-Hispanic) and African-American Groups
- (2014) Naif Zaman et al. PLoS One
- GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
- (2014) Bin He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor clone dynamics in lethal prostate cancer
- (2014) S. Carreira et al. Science Translational Medicine
- Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program
- (2014) Hong-Jian Jin et al. Nature Communications
- Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
- (2014) Jian An et al. Cell Reports
- Androgen deprivation therapy: evidence-based management of side effects
- (2013) Hamed Ahmadi et al. BJU INTERNATIONAL
- First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer
- (2013) D Bianchini et al. BRITISH JOURNAL OF CANCER
- The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity
- (2013) Jianfei Qi et al. CANCER CELL
- High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development
- (2013) D. Lin et al. CANCER RESEARCH
- An androgen receptor N-terminal domain antagonist for treating prostate cancer
- (2013) Jae-Kyung Myung et al. JOURNAL OF CLINICAL INVESTIGATION
- CCAR1 promotes chromatin loading of androgen receptor (AR) transcription complex by stabilizing the association between AR and GATA2
- (2013) W.-Y. Seo et al. NUCLEIC ACIDS RESEARCH
- Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype
- (2013) J L L Robinson et al. ONCOGENE
- Mechanisms of the androgen receptor splicing in prostate cancer cells
- (2013) L L Liu et al. ONCOGENE
- Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
- (2013) C. Geng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer
- (2013) M. D. Nyquist et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- How Sex Hormones Promote Skeletal Muscle Regeneration
- (2013) Martina Velders et al. SPORTS MEDICINE
- Peptidomimetic targeting of critical androgen receptor–coregulator interactions in prostate cancer
- (2013) Preethi Ravindranathan et al. Nature Communications
- An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)
- (2013) M. Korpal et al. Cancer Discovery
- A Clinically Relevant Androgen Receptor Mutation Confers Resistance to Second-Generation Antiandrogens Enzalutamide and ARN-509
- (2013) J. D. Joseph et al. Cancer Discovery
- Overcoming mutation-based resistance to antiandrogens with rational drug design
- (2013) Minna D Balbas et al. eLife
- ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
- (2012) N. J. Clegg et al. CANCER RESEARCH
- Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
- (2012) R. Hu et al. CANCER RESEARCH
- Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines
- (2012) Y. Li et al. CANCER RESEARCH
- Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity
- (2012) Himisha Beltran et al. EUROPEAN UROLOGY
- Targeted disruption of the p160 coactivator interface of androgen receptor (AR) selectively inhibits AR activity in both androgen-dependent and castration-resistant AR-expressing prostate cancer cells
- (2012) Manjula Nakka et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal
- (2012) Siu Chiu Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?
- (2012) T. E. Hickey et al. MOLECULAR ENDOCRINOLOGY
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
- (2012) Christopher E Barbieri et al. NATURE GENETICS
- Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
- (2012) Howard I. Scher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
- (2012) Charles J. Ryan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells
- (2012) S Sarkar et al. ONCOGENE
- Modeling Truncated AR Expression in a Natural Androgen Responsive Environment and Identification of RHOB as a Direct Transcriptional Target
- (2012) Hui-Chi Tsai et al. PLoS One
- FOXA1 Promotes Tumor Progression in Prostate Cancer and Represents a Novel Hallmark of Castration-Resistant Prostate Cancer
- (2011) Josefine Gerhardt et al. AMERICAN JOURNAL OF PATHOLOGY
- Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1
- (2011) Changmeng Cai et al. CANCER CELL
- Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
- (2011) Biswajyoti Sahu et al. EMBO JOURNAL
- High-level expression of forkhead-box protein A1 in metastatic prostate cancer
- (2011) Rohit K Jain et al. HISTOPATHOLOGY
- Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice
- (2011) Karel De Gendt et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Reduced Expression of the Androgen Receptor by Third Generation of Antisense Shows Antitumor Activity in Models of Prostate Cancer
- (2011) Y. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
- (2011) Dong Wang et al. NATURE
- Abiraterone and Increased Survival in Metastatic Prostate Cancer
- (2011) Johann S. de Bono et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival
- (2011) Emma Hörnberg et al. PLoS One
- Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
- (2011) L. V. Sequist et al. Science Translational Medicine
- Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
- (2010) Raymond J. Andersen et al. CANCER CELL
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Detection of Androgen Receptor Mutations in Circulating Tumor Cells in Castration-Resistant Prostate Cancer
- (2010) Y. Jiang et al. CLINICAL CHEMISTRY
- Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
- (2010) Shihua Sun et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
- (2010) Jianming Zhang et al. NATURE
- Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
- (2010) P. A. Watson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity
- (2010) Hiromitsu Kawata et al. PROSTATE
- The ubiquitin-proteasome system in prostate cancer and its transition to castration resistance
- (2010) Ioannis A. Voutsadakis et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination
- (2009) Kexin Xu et al. CANCER CELL
- Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
- (2009) M. P. Steinkamp et al. CANCER RESEARCH
- A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth
- (2009) Z. Guo et al. CANCER RESEARCH
- Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
- (2009) Qianben Wang et al. CELL
- A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes
- (2009) M Böhm et al. ONCOGENE
- Coactivator selective regulation of androgen receptor activity
- (2009) Irina U. Agoulnik et al. STEROIDS
- Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells
- (2008) Yue-Qing Tang et al. ASIAN JOURNAL OF ANDROLOGY
- Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance
- (2008) S. M. Dehm et al. CANCER RESEARCH
- Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer
- (2008) R. Hu et al. CANCER RESEARCH
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