Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Authors
Keywords
-
Journal
Nature Communications
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-11-22
DOI
10.1038/s41467-017-01969-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
- (2016) J. M. Backer BIOCHEMICAL JOURNAL
- Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
- (2016) Samira Alliouachene et al. DIABETOLOGIA
- mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
- (2015) M. J. Munson et al. EMBO JOURNAL
- PI(5)P Regulates Autophagosome Biogenesis
- (2015) Mariella Vicinanza et al. MOLECULAR CELL
- Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo
- (2015) Ayako Honda et al. ACS Medicinal Chemistry Letters
- Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling
- (2015) Ivan Nemazanyy et al. Nature Communications
- Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
- (2015) Samira Alliouachene et al. Cell Reports
- Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
- (2015) Julie Guillermet-Guibert et al. PLoS Genetics
- Conditional Knockout of Pik3c3 Causes a Murine Muscular Dystrophy
- (2014) Aaron Reifler et al. AMERICAN JOURNAL OF PATHOLOGY
- Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
- (2014) Ruzica Bago et al. BIOCHEMICAL JOURNAL
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
- (2014) William E. Dowdle et al. NATURE CELL BIOLOGY
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism
- (2013) Congcong He et al. CELL
- Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease
- (2013) Ivan Nemazanyy et al. EMBO Molecular Medicine
- Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
- (2013) Camilla Raiborg et al. FEBS Journal
- Deletion of Autophagy-related 5 (Atg5) andPik3c3Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation
- (2013) Hideaki Morishita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34
- (2013) V. V. Parekh et al. JOURNAL OF IMMUNOLOGY
- Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
- (2013) Russell A. Miller et al. NATURE
- Exercise, GLUT4, and Skeletal Muscle Glucose Uptake
- (2013) Erik A. Richter et al. PHYSIOLOGICAL REVIEWS
- Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis
- (2013) Kelly Devereaux et al. PLoS One
- Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling
- (2013) Sarah Carpentier et al. TRAFFIC
- A novel mass assay to quantify the bioactive lipid PtdIns3Pin various biological samples
- (2012) Gaëtan Chicanne et al. BIOCHEMICAL JOURNAL
- Erratum: Illuminating the functional and structural repertoire of human TBC/RABGAPs
- (2012) Marieke A. M. Frasa et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis
- (2012) T. Willinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function
- (2012) N. Jaber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
- (2011) Junji Ezaki et al. Autophagy
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
- (2011) R. K. Amaravadi et al. CLINICAL CANCER RESEARCH
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- The Class III Kinase Vps34 Promotes T Lymphocyte Survival through Regulating IL-7Rα Surface Expression
- (2011) Ian X. McLeod et al. JOURNAL OF IMMUNOLOGY
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation
- (2011) Xiang Zhou et al. PLoS One
- Human Fatty Liver Disease: Old Questions and New Insights
- (2011) J. C. Cohen et al. SCIENCE
- Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
- (2010) Hannah E.J. Polson et al. Autophagy
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
- (2010) Marc Foretz et al. JOURNAL OF CLINICAL INVESTIGATION
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration
- (2010) L. Wang et al. NEUROSCIENCE
- Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway
- (2010) X. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2
- (2009) Gerald R. V. Hammond et al. BIOCHEMICAL JOURNAL
- The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease
- (2009) Stergios A. Polyzos et al. DIABETES OBESITY & METABOLISM
- Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice
- (2009) Anurag Kumar Singh et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
- (2009) Y. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
- (2008) Chie Ebato et al. Cell Metabolism
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now