The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

(2018) Shireen Chikara et al.   CANCER LETTERS

Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology

(2018) Martina Magni et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells

(2018) Ting Sun et al.   Cell Death & Disease

SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer

(2018) Khaldoun Rifaï et al.   Oncotarget

TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage

(2018) Martina Magni et al.   CELL DEATH AND DIFFERENTIATION

Ketogenic Diet Modulates NAD+-Dependent Enzymes and Reduces DNA Damage in Hippocampus

(2018) Marwa Elamin et al.   Frontiers in Cellular Neuroscience

Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage

(2018) Stuart G. Jarrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

(2017) Renea P. Jablonski et al.   FASEB JOURNAL

Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress

(2017) Jianing Zhong et al.   International Journal of Biological Sciences

SIRT1 regulates Mxd1 during malignant melanoma progression

(2017) Fabiana M. Meliso et al.   Oncotarget

SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair

(2017) Jiho Jang et al.   Stem Cell Reports

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

(2016) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells

(2016) Mendel Roth et al.   Oncotarget

SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

(2016) Linh Ho et al.   Aging-US

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

(2015) Rishabh Kala et al.   BMC CANCER

Differential DNA lesion formation and repair in heterochromatin and euchromatin

(2015) Chunhua Han et al.   CARCINOGENESIS

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

(2015) Emelyn H. Shroff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage

(2015) Ning Ding et al.   Journal of Molecular Cell Biology

CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage

(2015) Martina Magni et al.   Oncotarget

The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes

(2015) Erika S. Langsfeld et al.   PLoS Pathogens

KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair

(2015) Yi-Hui Lin et al.   PLoS One

Sirtuin deacetylases: A new target for melanoma management

(2014) Melissa J Wilking et al.   CELL CYCLE

DNA breaks and chromosomal aberrations arise when replication meets base excision repair

(2014) Michael Ensminger et al.   JOURNAL OF CELL BIOLOGY

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

(2013) Zhi-Feng Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chromatin modifications during repair of environmental exposure-induced DNA damage: A potential mechanism for stable epigenetic alterations

(2013) Heather M. O'Hagan   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

ARF induction in response to DNA strand breaks is regulated by PARP1

(2013) Giulia Orlando et al.   NUCLEIC ACIDS RESEARCH

Chromatin modifications and the DNA damage response to ionizing radiation

(2013) Rakesh Kumar et al.   Frontiers in Oncology

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

(2012) Z Wang et al.   ONCOGENE

Sirtuins, Metabolism, and Cancer

(2012) Barbara Martinez-Pastor et al.   Frontiers in Pharmacology

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

(2011) Heather M. O'Hagan et al.   CANCER CELL

FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide

(2011) Katherine J. Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription

(2011) Ramkumar Rajendran et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

The Arf/p53 Pathway in Cancer and Aging

(2008) A. Matheu et al.   CANCER RESEARCH

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

The endless tale of non-homologous end-joining

(2008) Eric Weterings et al.   CELL RESEARCH

Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein

(2008) Tomoaki Kahyo et al.   FEBS LETTERS

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE