The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity

(2019) Pamlea N. Brady et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

PARP6 inhibition as a strategy to exploit centrosome clustering in cancer cells?

(2019) Zebin Wang et al.   Oncotarget

Tankyrase (PARP5) Inhibition Induces Bone Loss through Accumulation of Its Substrate SH3BP2

(2019) Tomoyuki Mukai et al.   Cells

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders

(2019) Giovanna Grimaldi et al.   BIOCHEMICAL PHARMACOLOGY

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

(2019) Ewa Gogola et al.   CANCER CELL

Novel insights into PARPs in gene expression: regulation of RNA metabolism

(2019) Yueshuang Ke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

(2019) Xiaoxiao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide-donor/PARP-inhibitor combination: A new approach for sensitization to ionizing radiation

(2019) Aaron Wilson et al.   Redox Biology

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes

(2019) Ameer Ali Bohio et al.   JOURNAL OF IMMUNOLOGY

Clinical Development of PARP Inhibitors in Treating Metastatic Castration-Resistant Prostate Cancer

(2019) Jacob J. Adashek et al.   Cells

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

(2019) Sylvie M. Noordermeer et al.   TRENDS IN CELL BIOLOGY

PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials

(2018) Dalia Kamel et al.   CURRENT DRUG TARGETS

Regulation of poly ADP-Ribose polymerase 1 functions by post-translational modifications

(2018) Ryuji Hamamoto   Frontiers in Bioscience-Landmark

PARP1 Stabilizes CTCF Binding and Chromatin Structure to Maintain Epstein Barr Virus Latency Type

(2018) Lena N. Lupey-Green et al.   JOURNAL OF VIROLOGY

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Metabolic regulation of transcription through compartmentalized NAD+biosynthesis

(2018) Keun Woo Ryu et al.   SCIENCE

OGG1-initiated base excision repair exacerbates oxidative stress-induced parthanatos

(2018) Ruoxi Wang et al.   Cell Death & Disease

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

(2018) Jone Michelena et al.   Nature Communications

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines

(2018) Bahram Sharif-Askari et al.   BREAST CANCER RESEARCH AND TREATMENT

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

Poly(ADP‑ribose) polymerase‑3 overexpression is associated with poor prognosis in patients with breast cancer following chemotherapy

(2018) Zhiguo Song et al.   Oncology Letters

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme

(2018) Mario Leutert et al.   Cell Reports

Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation

(2018) Sara C. Larsen et al.   Cell Reports

Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity

(2018) Alvin Gomez et al.   BIOCHEMICAL JOURNAL

PARPs in genome stability and signal transduction: implications for cancer therapy

(2018) Luca Palazzo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer

(2018) Zebin Wang et al.   CANCER RESEARCH

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Novel insight into the function of tankyrase (Review)

(2018) Mi Kim   Oncology Letters

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Hu antigen R (HuR) multimerization contributes to glioma disease progression

(2017) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

(2017) Xin Luo et al.   MOLECULAR CELL

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1

(2017) Arthur Fischbach et al.   NUCLEIC ACIDS RESEARCH

The role of poly ADP-ribosylation in the first wave of DNA damage response

(2017) Chao Liu et al.   NUCLEIC ACIDS RESEARCH

Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells

(2017) Haipeng Wang et al.   ONCOLOGY REPORTS

PARP1 orchestrates epigenetic events setting up chromatin domains

(2017) Fabio Ciccarone et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PARP, transcription and chromatin modeling

(2017) Melanija Posavec Marjanović et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter

(2017) Lena N. Lupey-Green et al.   VIROLOGY

Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

(2017) Yueshuang Ke et al.   Nature Communications

PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma

(2017) Balázs Murnyák et al.   Oncotarget

Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review

(2017) Gurupreet S. Sethi et al.   Frontiers in Immunology

TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors

(2016) C. Bindesboll et al.   BIOCHEMICAL JOURNAL

Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II

(2016) Shu-jian Wei et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

New directions in poly(ADP-ribose) polymerase biology

(2016) Florian J. Bock et al.   FEBS Journal

JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production

(2016) Linjie Zheng et al.   MOLECULAR NEUROBIOLOGY

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

(2016) Roni H. G. Wright et al.   SCIENCE

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies

(2016) Xia Ding et al.   Nature Communications

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

(2016) Hiroshi Iwata et al.   Nature Communications

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

(2016) Gabrielle J. Grundy et al.   Nature Communications

PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer

(2016) Guangying Qi et al.   Oncotarget

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis

(2016) Olga Karicheva et al.   Oncotarget

Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs

(2016) Zita Nagy et al.   PLoS Genetics

PARP inhibitors in the management of breast cancer: current data and future prospects

(2015) Luca Livraghi et al.   BMC Medicine

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases

(2015) Keun Woo Ryu et al.   CHEMICAL REVIEWS

PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription

(2015) Honglei Zhao et al.   MOLECULAR CELL

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

(2015) Amanda A. Riccio et al.   NUCLEIC ACIDS RESEARCH

Readers of poly(ADP-ribose): designed to be fit for purpose

(2015) Federico Teloni et al.   NUCLEIC ACIDS RESEARCH

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha

(2015) Enkhzaya Batnasan et al.   TOXICOLOGY LETTERS

Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer

(2015) Tanya Todorova et al.   TRENDS IN MOLECULAR MEDICINE

Nuclear PARP1 expression and its prognostic significance in breast cancer patients

(2015) Annalisa Mazzotta et al.   TUMOR BIOLOGY

Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-α-stimulated murine lung epithelial cells via depressing PARP-1 activity

(2014) Hai-yan Li et al.   ACTA PHARMACOLOGICA SINICA

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

(2014) M. B. Iqbal et al.   BLOOD

DNA Damage Response and Metabolic Disease

(2014) Ippei Shimizu et al.   Cell Metabolism

Mechanisms That Regulate Macrophage Burden in Atherosclerosis

(2014) Gwendalyn J Randolph   CIRCULATION RESEARCH

Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

(2014) Carole Beck et al.   EXPERIMENTAL CELL RESEARCH

Original article Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas

(2014) Tamás Csonka et al.   FOLIA NEUROPATHOLOGICA

PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation

(2014) Iain Welsby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript

(2014) Tanya Todorova et al.   Nature Communications

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

(2013) Yingbiao Ji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis

(2013) Amit Kamboj et al.   Journal of Neuroinflammation

Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications

(2013) Suowen Xu et al.   MEDICINAL RESEARCH REVIEWS

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

(2013) Carles Cantó et al.   MOLECULAR ASPECTS OF MEDICINE

PARP-1 and gene regulation: Progress and puzzles

(2013) W. Lee Kraus et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10

(2013) Patricia Verheugd et al.   Nature Communications

The pathogenesis of Epstein–Barr virus persistent infection

(2013) David A Thorley-Lawson et al.   Current Opinion in Virology

Beyond DNA Repair: Additional Functions of PARP-1 in Cancer

(2013) Alice N. Weaver et al.   Frontiers in Oncology

PARty promoters

(2012) Roni H.G. Wright et al.   CELL CYCLE

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

(2012) P. Russo et al.   CURRENT MEDICINAL CHEMISTRY

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Lipopolysaccharide activates ERK–PARP-1–RelA pathway and promotes nuclear factor–κB transcription in murine macrophages

(2012) Linlin Liu et al.   HUMAN IMMUNOLOGY

PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development

(2012) HANDAN TUNCEL et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of B-NHEJ in Plateau-Phase Cells Is Not a Direct Consequence of Suppressed Growth Factor Signaling

(2012) Satyendra K. Singh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Reprogramming cellular events by poly(ADP-ribose)-binding proteins

(2012) Jana Krietsch et al.   MOLECULAR ASPECTS OF MEDICINE

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

(2012) Miri Jwa et al.   NATURE CELL BIOLOGY

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer

(2012) Jonathan Ledermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation

(2012) Laura MacPherson et al.   NUCLEIC ACIDS RESEARCH

YY1-Binding Sites Provide Central Switch Functions in the PARP-1 Gene Expression Network

(2012) Martina Doetsch et al.   PLoS One

Systematic identification of type I and type II interferon-induced antiviral factors

(2012) S.-Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of PARP1 in the DNA damage response and its application in tumor therapy

(2012) Zhifeng Wang et al.   Frontiers of Medicine

PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model

(2011) R. Datta et al.   ALLERGY

Signaling Mechanism of Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Inflammatory Diseases

(2011) Xueqing Ba et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy

(2011) Pawel Domagala et al.   BREAST CANCER RESEARCH AND TREATMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

(2011) Péter Bai et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

(2011) Shaida A Andrabi et al.   NATURE MEDICINE

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

(2010) Purvi Mehrotra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poly(ADP-Ribose) Polymerase-1 Is a Determining Factor in Crm1-Mediated Nuclear Export and Retention of p65 NF- B upon TLR4 Stimulation

(2010) M. Zerfaoui et al.   JOURNAL OF IMMUNOLOGY

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

(2010) L Nicolás et al.   ONCOGENE

Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer

(2010) Zhen-Yu He   WORLD JOURNAL OF GASTROENTEROLOGY

The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor

(2009) Xiao-Lan Xu et al.   CARCINOGENESIS

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

(2009) Yingfei Wang et al.   EXPERIMENTAL NEUROLOGY

PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases

(2009) Andreína Peralta-Leal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Poly(ADP-Ribose) Polymerase Suppresses Inflammation and Promotes Recovery after Ischemic Injury

(2009) Tiina M Kauppinen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mutational Analysis of the Poly(ADP-Ribosyl)ation Sites of the Transcription Factor CTCF Provides an Insight into the Mechanism of Its Regulation by Poly(ADP-Ribosyl)ation

(2009) D. Farrar et al.   MOLECULAR AND CELLULAR BIOLOGY

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Poly(ADP-ribosyl)ation of heterogeneous nuclear ribonucleoproteins modulates splicing

(2009) Yingbiao Ji et al.   NUCLEIC ACIDS RESEARCH

eNOS, metabolic syndrome and cardiovascular disease

(2009) Paul L. Huang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease

(2008) Pal Pacher et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Poly(ADP-ribose) polymerase activity in different pathologies – The link to inflammation and infarction

(2008) Sascha Beneke   EXPERIMENTAL GERONTOLOGY

Regulation of Transcription Factor NFAT by ADP-Ribosylation

(2008) O. A. Olabisi et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE