Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer—from Tumor Development to Therapeutic Implications

The Changing Landscape of Systemic Treatment of Advanced Hepatocellular Carcinoma: New Targeted Agents and Immunotherapies

(2019) Jens U. Marquardt et al.   Targeted Oncology

The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer

(2019) Jelena Todoric et al.   CANCER CELL

Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma

(2019) Jiajia He et al.   CANCER LETTERS

Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2

(2018) Elham Ahmadian et al.   BIOMEDICINE & PHARMACOTHERAPY

RA190, a Proteasome Subunit ADRM1 Inhibitor, Suppresses Intrahepatic Cholangiocarcinoma by Inducing NF-KB-Mediated Cell Apoptosis

(2018) Guang-Yang Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma

(2018) Oriana Lo Re et al.   HEPATOLOGY

The role of molecular enrichment on future therapies in hepatocellular carcinoma

(2018) Jean-Charles Nault et al.   JOURNAL OF HEPATOLOGY

Perindopril, fosinopril and losartan inhibited the progression of diethylnitrosamine-induced hepatocellular carcinoma in mice via the inactivation of nuclear transcription factor kappa-B

(2018) Sameh Saber et al.   TOXICOLOGY LETTERS

Immunotherapy of Hepatocellular Carcinoma

(2018) Bernd Heinrich et al.   Oncology Research and Treatment

MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer

(2018) Jin’en Wu et al.   Frontiers in Immunology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

(2018) Marcus Grohmann et al.   CELL

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

The trends in incidence of primary liver cancer caused by specific etiologies: Results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention

(2018) Zhenqiu Liu et al.   JOURNAL OF HEPATOLOGY

COMMD7 Regulates NF-κB Signaling Pathway in Hepatocellular Carcinoma Stem-like Cells

(2018) Lu Zheng et al.   Molecular Therapy-Oncolytics

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

(2017) Hyunju Oh et al.   IMMUNITY

Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway

(2017) Kewei Ren et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma

(2017) Jianhua Liu et al.   ONCOLOGY REPORTS

Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis

(2017) Janaki K Iyer et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas

(2017) Darko Castven et al.   Oncotarget

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction

(2016) Tahir Mehmood et al.   BIOFACTORS

Role of Immunity in Pathogenesis and Treatment of Hepatocellular Carcinoma

(2016) Nathalie Schmidt et al.   DIGESTIVE DISEASES

TLR2 promotes human intrahepatic cholangiocarcinoma cell migration and invasion by modulating NF-κB pathway-mediated inflammatory responses

(2016) Bingyan Liu et al.   FEBS Journal

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response

(2016) Yoshiaki Sunami et al.   HEPATOLOGY

Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1

(2016) I-Fang Hsin et al.   HEPATOLOGY

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype

(2016) Matthias S. Matter et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Cutting Edge: Engineering Active IKKβ in T Cells Drives Tumor Rejection

(2016) César Evaristo et al.   JOURNAL OF IMMUNOLOGY

Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells

(2016) Jai-Jen Tsai et al.   ONCOLOGY REPORTS

High expression of Snail and NF-κB predicts poor survival in Chinese hepatocellular carcinoma patients

(2016) Min Zhang et al.   Oncotarget

Mechanistic insights of O-GlcNAcylation that promote progression of cholangiocarcinoma cells via nuclear translocation of NF-κB

(2016) Chatchai Phoomak et al.   Scientific Reports

EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma

(2016) Da-long Yin et al.   Scientific Reports

URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway

(2015) Sizhong Xing et al.   BMC CANCER

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

PD-1 Blunts the Function of Ovarian Tumor–Infiltrating Dendritic Cells by Inactivating NF-κB

(2015) Lavakumar Karyampudi et al.   CANCER RESEARCH

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Romo1 and the NF-κB pathway are involved in oxidative stress-induced tumor cell invasion

(2015) SORA LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer

(2015) Jens U. Marquardt et al.   JOURNAL OF HEPATOLOGY

Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

(2015) Fei Wang et al.   Molecular Cancer

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Cancer risk: Role of environment--Response

(2015) C. Tomasetti et al.   SCIENCE

Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway

(2015) Lei Cao et al.   Oncotarget

Curcumin Sensitizes Hepatocellular Carcinoma Cells to Radiation via Suppression of Radiation-Induced NF-κB Activity

(2015) Fei-Ting Hsu et al.   Biomed Research International

Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression

(2014) Shu-Ching Hsieh et al.   AMINO ACIDS

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

(2014) H Ehlken et al.   CELL DEATH AND DIFFERENTIATION

Emerging trends in hepatocellular carcinoma incidence and mortality

(2014) Basile Njei et al.   HEPATOLOGY

Sorafenib increases efficacy of vorinostat against human hepatocellular carcinoma through transduction inhibition of vorinostat-induced ERK/NF-κB signaling

(2014) FEI-TING HSU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type

(2014) Shinichi Aishima et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Proliferation inhibition and differentiation induction of hepatic cancer stem cells by knockdown of BC047440: A potential therapeutic target of stem cell treatment for hepatocellular carcinoma

(2014) NAN YOU et al.   ONCOLOGY REPORTS

Aberrant Expression of NF-κB in Liver Fluke Associated Cholangiocarcinoma: Implications for Targeted Therapy

(2014) Wunchana Seubwai et al.   PLoS One

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

TNFR1 determines progression of chronic liver injury in the IKKγ/Nemo genetic model

(2013) F J Cubero et al.   CELL DEATH AND DIFFERENTIATION

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Inhibition of nuclear factor-κB enhances the antitumor effect of tumor necrosis factor-α gene therapy for hepatocellular carcinoma in mice

(2013) Koichiro Haruki et al.   SURGERY

The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism

(2012) Nadia Lampiasi et al.   CANCER LETTERS

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Genetic profiling of intrahepatic cholangiocarcinoma

(2012) Jesper B. Andersen et al.   CURRENT OPINION IN GASTROENTEROLOGY

Overexpression of Romo1 Promotes Production of Reactive Oxygen Species and Invasiveness of Hepatic Tumor Cells

(2012) Jin Sil Chung et al.   GASTROENTEROLOGY

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma

(2012) Naoki Oishi et al.   HEPATOLOGY

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation

(2012) Yoshiaki Sunami et al.   HEPATOLOGY

Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response

(2012) Anna Moles et al.   HEPATOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways

(2011) S. Prakobwong et al.   CARCINOGENESIS

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

(2011) Christian Liedtke et al.   GASTROENTEROLOGY

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

NEMO expression in human hepatocellular carcinoma and its association with clinical outcome

(2011) Ariane Aigelsreiter et al.   HUMAN PATHOLOGY

Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies

(2011) Jens U. Marquardt et al.   JOURNAL OF HEPATOLOGY

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic Stellate Cells in Inflammation-Fibrosis-Carcinoma Axis

(2010) Bin-Bin Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers

(2010) Rashmi Singh et al.   CLINICAL IMMUNOLOGY

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

(2009) Y. Hoshida et al.   CANCER RESEARCH

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

(2009) Johannes Kluwe et al.   GASTROENTEROLOGY

S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis

(2009) Julia Németh et al.   HEPATOLOGY

Antitumor Effects of Dehydroxymethylepoxyquinomicin, a Novel Nuclear Factor- B Inhibitor, in Human Liver Cancer Cells Are Mediated through a Reactive Oxygen Species-Dependent Mechanism

(2009) N. Lampiasi et al.   MOLECULAR PHARMACOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL

p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin-induced liver failure

(2008) Jan Heinrichsdorff et al.   EMBO REPORTS

Down-Regulation of Osteopontin Suppresses Growth and Metastasis of Hepatocellular Carcinoma Via Induction of Apoptosis

(2008) Jian Zhao et al.   GASTROENTEROLOGY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

(2008) T. Luedde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol inhibits tumor necrosis factor-α-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells

(2007) Haibo Yu et al.   BIOMEDICINE & PHARMACOTHERAPY