Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders
Authors
Keywords
Poly(ADP-ribose)polymerase-1 (PARP1), DNA repair, Nicotinamide adenine dinucleotide (NAD+), Adenosine triphosphate (ATP), Atherosclerosis, Acute myocardial infarction, Heart failure, PARP inhibition
Journal
Cardiovascular Toxicology
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-07-02
DOI
10.1007/s12012-018-9462-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Role of Peroxynitrite-Induced Activation of Poly(ADP-Ribose) Polymerase (PARP) in Circulatory Shock and Related Pathological Conditions
- (2016) Badar Ul Islam et al. Cardiovascular Toxicology
- Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II
- (2016) Shu-jian Wei et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Effects of 3-aminobenzamide on ventricular function in infarct heart assessed by quantitative tissue velocity imaging
- (2016) Man Wang et al. Journal of Cardiovascular Medicine
- Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes
- (2014) Robert J. Henning et al. CYTOTHERAPY
- PARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
- (2014) Laszlo Deres et al. PLoS One
- Human Umbilical Cord Blood Mononuclear Cell-Conditioned Media Inhibits Hypoxic-Induced Apoptosis in Human Coronary Artery Endothelial Cells and Cardiac Myocytes by Activation of the Survival Protein Akt
- (2013) Hua Jin et al. CELL TRANSPLANTATION
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- (2013) Anu Kauppinen et al. CELLULAR SIGNALLING
- Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications
- (2013) Suowen Xu et al. MEDICINAL RESEARCH REVIEWS
- Therapeutic applications of PARP inhibitors: Anticancer therapy and beyond
- (2013) Nicola J. Curtin et al. MOLECULAR ASPECTS OF MEDICINE
- Poly(ADP-ribose) signaling in cell death
- (2013) László Virág et al. MOLECULAR ASPECTS OF MEDICINE
- PARP-1 and gene regulation: Progress and puzzles
- (2013) W. Lee Kraus et al. MOLECULAR ASPECTS OF MEDICINE
- 50Years of poly(ADP-ribosyl)ation
- (2013) László Virág MOLECULAR ASPECTS OF MEDICINE
- The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
- (2012) Mike De Vos et al. BIOCHEMICAL PHARMACOLOGY
- On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
- (2012) X. Luo et al. GENES & DEVELOPMENT
- Poly(ADP-Ribose) Polymerase 1 Inhibition Improves Coronary Arteriole Function in Type 2 Diabetes Mellitus
- (2012) Soo-Kyoung Choi et al. HYPERTENSION
- Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
- (2012) Elisabet Wahlberg et al. NATURE BIOTECHNOLOGY
- Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress
- (2012) Jean-Philippe Gagné et al. NUCLEIC ACIDS RESEARCH
- Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury
- (2011) Partha Mukhopadhyay et al. FREE RADICAL BIOLOGY AND MEDICINE
- Poly (ADP-Ribose) Polymerase Inhibition Attenuates Atherosclerotic Plaque Development in ApoE-/- Mice with Hyperhomocysteinemia
- (2011) Jiang-jiao Xie et al. Journal of Atherosclerosis and Thrombosis
- Regulation of Kinase Cascade Activation and Heat Shock Protein Expression by Poly(ADP-ribose) Polymerase Inhibition in Doxorubicin-induced Heart Failure
- (2011) Eva Bartha et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury:in vitrostudy of isolated rat heart model
- (2011) Kazuhiro Yamazaki et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Mitochondrial and Nuclear Cross Talk in Cell Death
- (2010) Shaida A. Andrabi et al. Annals of the New York Academy of Sciences
- Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy
- (2010) Chetan P. Hans et al. CARDIOVASCULAR PATHOLOGY
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
- (2010) Raga Krishnakumar et al. MOLECULAR CELL
- THERAPEUTIC INJECTION OF PARP INHIBITOR INO-1001 PRESERVES CARDIAC FUNCTION IN PORCINE MYOCARDIAL ISCHEMIA AND REPERFUSION WITHOUT REDUCING INFARCT SIZE
- (2010) Jan P. Roesner et al. SHOCK
- PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats
- (2009) E. Bartha et al. CARDIOVASCULAR RESEARCH
- Superoxide, no, peroxynitrite and PARP in circulatory shock and inflammation
- (2009) Emanuela Esposito Frontiers in Bioscience-Landmark
- Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content
- (2009) C. P. Hans et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Protective Effects of PARP-1 Knockout on Dyslipidemia-Induced Autonomic and Vascular Dysfunction in ApoE−/− Mice: Effects on eNOS and Oxidative Stress
- (2009) Chetan P. Hans et al. PLoS One
- Poly (ADP-ribose) Polymerase Inhibition Improves Endothelial Dysfunction Induced by Hyperhomocysteinemia in Rats
- (2008) Xian Yu et al. CARDIOVASCULAR DRUGS AND THERAPY
- Inducible and endothelial nitric oxide synthase expression in human atherogenesis: an immunohistochemical and ultrastructural study
- (2008) Ida Perrotta et al. CARDIOVASCULAR PATHOLOGY
- Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability
- (2008) C. P. Hans et al. CARDIOVASCULAR RESEARCH
- Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injuryviasuppressing JNK-mediated AIF translocation
- (2008) Zhao-Feng Song et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial
- (2008) David A. Morrow et al. JOURNAL OF THROMBOSIS AND THROMBOLYSIS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started