Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis

Circulating IFN-γ producing CD4+ T cells and IL-17A producing CD4+ T cells, HLA-shared epitope and ACPA may characterize the clinical response to therapy in rheumatoid arthritis patients

(2020) Niloofar Alvandpur et al.   HUMAN IMMUNOLOGY

Immunometabolism in the development of rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   IMMUNOLOGICAL REVIEWS

Dimethyl fumarate prevents osteoclastogenesis by decreasing NFATc1 expression, inhibiting of erk and p38 MAPK phosphorylation, and suppressing of HMGB1 release

(2020) Tsuyoshi Nishioku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulated PKM2 in Macrophages Exacerbates Experimental Arthritis via STAT1 Signaling

(2020) Jing Xu et al.   JOURNAL OF IMMUNOLOGY

Melatonin in macrophage biology: Current understanding and future perspectives

(2019) Yaoyao Xia et al.   JOURNAL OF PINEAL RESEARCH

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

(2019) Zhenke Wen et al.   NATURE IMMUNOLOGY

Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis

(2019) Sudhir Kumar Yadav et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

T-cells interact with B cells, dendritic cells, and fibroblast-like synoviocytes as hub-like key cells in rheumatoid arthritis

(2019) Xiao-Xi Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway

(2019) Jing Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Immunometabolism: an overview and therapeutic prospects in autoimmune diseases

(2019) Chrysoula Stathopoulou et al.   Immunotherapy

Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients

(2019) Sara Biasi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The impaired gene expression of adenosine monophosphate-activated kinase (AMPK), a key metabolic enzyme in leukocytes of newly diagnosed rheumatoid arthritis patients

(2019) Zahra Samimi et al.   MOLECULAR BIOLOGY REPORTS

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

(2019) Patricia Gnieslaw de Oliveira et al.   Frontiers in Immunology

Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases

(2019) Paola Di Benedetto et al.   AUTOIMMUNITY REVIEWS

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

(2019) Stefano Angiari et al.   Cell Metabolism

Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast‐like synoviocytes of rheumatoid arthritis

(2019) Xiaoyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-α

(2019) Huimin Deng et al.   CYTOKINE

Barbaloin Attenuates Mucosal Damage in Experimental Models of Rat Colitis by Regulating Inflammation and the AMPK Signaling Pathway

(2019) Ling Gai et al.   MEDICAL SCIENCE MONITOR

PKM2: A Potential Regulator of Rheumatoid Arthritis via Glycolytic and Non-Glycolytic Pathways

(2019) Danyi Xu et al.   Frontiers in Immunology

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

(2018) André L. Saraiva et al.   FASEB JOURNAL

Innate immunity and tolerance toward mitochondria

(2018) Anthony Rongvaux   MITOCHONDRION

Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

(2018) Claire Speirs et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

(2018) Angelika S. Rambold et al.   TRENDS IN IMMUNOLOGY

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

Optimization of Polycistronic Anti-CCR5 Artificial microRNA Leads to Improved Accuracy of Its Lentiviral Vector Transfer and More Potent Inhibition of HIV-1 in CD4+ T-Cells

(2018) et al.   Cells

Evolving Concepts of Mitochondrial Dynamics

(2018) Gerald W. Dorn   Annual Review of Physiology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2018) David O’Sullivan et al.   IMMUNITY

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis

(2018) Pavanish Kumar et al.   JOURNAL OF AUTOIMMUNITY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization

(2018) Qiuyue Kong et al.   DIABETES

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Genetic and Epigenetic Determinants in Autoinflammatory Diseases

(2017) Damiana Álvarez-Errico et al.   Frontiers in Immunology

3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation

(2017) Takaichi Okano et al.   Scientific Reports

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Coexistence of ischemic heart disease and rheumatoid arthritis patients—A case control study

(2016) Esther Houri Levi et al.   AUTOIMMUNITY REVIEWS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

(2016) Yinyin Li et al.   IMMUNITY

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis

(2016) Joong Kyong Ahn et al.   JOINT BONE SPINE

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis

(2016) Filippos Michopoulos et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis

(2016) Takayoshi Morita et al.   PLoS One

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

(2015) Peng Yang et al.   CELLULAR SIGNALLING

TNF-α-Induced NF-κB Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1α

(2015) A. H. V. Remels et al.   ENDOCRINOLOGY

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation

(2015) So Youn Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation and intracellular metabolism: new targets in OA

(2015) R. Liu-Bryan   OSTEOARTHRITIS AND CARTILAGE

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis

(2015) Monica Guma et al.   PLoS One

Mitochondria in lung biology and pathology: more than just a powerhouse

(2014) Paul T. Schumacker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

(2014) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluation of tocilizumab therapy in patients with rheumatoid arthritis based on FDG-PET/CT

(2014) Koichi Okamura et al.   BMC MUSCULOSKELETAL DISORDERS

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling

(2014) Peng Yang et al.   CELLULAR SIGNALLING

Metabolic Mysteries of the Inflammatory Response: T Cell Polarization and Plasticity

(2014) Kelley M. Fracchia et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect

(2014) Eduardo N. Maldonado et al.   MITOCHONDRION

Assessment of peripheral blood CD4+ adenosine triphosphate activity in patients with rheumatoid arthritis

(2014) Masaki Akimoto et al.   Modern Rheumatology

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

STAT3 Activities and Energy Metabolism: Dangerous Liaisons

(2014) Annalisa Camporeale et al.   Cancers

The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

(2013) Stephen P. Young et al.   ARTHRITIS AND RHEUMATISM

The function of the respiratory supercomplexes: The plasticity model

(2013) Rebeca Acin-Perez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis

(2013) Kwi Young Kang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondria and AMP-activated Protein Kinase-dependent Mechanism of Efferocytosis

(2013) Shaoning Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

T cell Activation Is Driven by an ADP-Dependent Glucokinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

(2012) Marcin M. Kamiński et al.   Cell Reports

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Disorders in angiogenesis and redox pathways are main factors contributing to the progression of rheumatoid arthritis: A comparative proteomics study

(2011) Jian-Guang Wang et al.   ARTHRITIS AND RHEUMATISM

NFκB and HIF display synergistic behaviour during hypoxic inflammation

(2011) Ulrike Bruning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Macrophages, Meta-Inflammation, and Immuno-Metabolism

(2011) Haim Shapiro et al.   TheScientificWorldJOURNAL

Redox signalling and the inflammatory response in rheumatoid arthritis

(2010) L. I. Filippin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Innate immunity, epigenetics and autoimmunity in rheumatoid arthritis

(2009) Hanna Maciejewska Rodrigues et al.   MOLECULAR IMMUNOLOGY