Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis
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Title
Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis
Authors
Keywords
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Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 74, Issue 6, Pages 1275-1283
Publisher
BMJ
Online
2014-02-14
DOI
10.1136/annrheumdis-2013-204105
References
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- (2011) Yoshiya Tanaka et al. ARTHRITIS CARE & RESEARCH
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- (2010) C. T. Ng et al. ANNALS OF THE RHEUMATIC DISEASES
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- (2010) Matthew A Bill et al. Molecular Cancer
- Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial
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- (2009) Joo Eun Jung et al. EXPERIMENTAL AND MOLECULAR MEDICINE
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- Notch Signal Activates Hypoxia Pathway through HES1-Dependent SRC/Signal Transducers and Activators of Transcription 3 Pathway
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