Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer
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Title
Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer
Authors
Keywords
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Journal
IMMUNOLOGICAL REVIEWS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-07-30
DOI
10.1111/imr.12906
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Note: Only part of the references are listed.- Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression
- (2020) Annika Hausmann et al. Mucosal Immunology
- NLRC4, ASC and Caspase-1 Are Inflammasome Components That Are Mediated by P2Y2R Activation in Breast Cancer Cells
- (2020) Hana Jin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma
- (2020) Jeannette L. Tenthorey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
- (2020) Shelbi Christgen et al. Frontiers in Cellular and Infection Microbiology
- NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD
- (2019) Koichiro Ohashi et al. HEPATOLOGY
- The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1
- (2019) Samuel J. Carpentier et al. Science Signaling
- Dendritic cell NLRC4 regulates influenza A virus–specific CD4+ T cell responses through FasL expression
- (2019) Emma E. Hornick et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential Expression Profile of NLRs and AIM2 in Glioma and Implications for NLRP12 in Glioblastoma
- (2019) Nidhi Sharma et al. Scientific Reports
- Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients
- (2019) Jaejoon Lim et al. Scientific Reports
- Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
- (2019) Augusto V. Gonçalves et al. PLoS Pathogens
- Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses
- (2019) Raphaela P. Semper et al. JOURNAL OF IMMUNOLOGY
- HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4
- (2019) Akhouri Kishore Raghawan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Emerging Activators and Regulators of Inflammasomes and Pyroptosis
- (2019) Yansong Xue et al. TRENDS IN IMMUNOLOGY
- A novel de novo NLRC4 mutation reinforces the likely pathogenicity of specific LRR domain mutation
- (2019) Chai Teng Chear et al. CLINICAL IMMUNOLOGY
- IRF8 Regulates Transcription of Naip s for NLRC4 Inflammasome Activation
- (2018) Rajendra Karki et al. CELL
- Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)–LRR oligomerization interface
- (2018) Fiona Moghaddas et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke
- (2018) Luting Poh et al. BRAIN BEHAVIOR AND IMMUNITY
- Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action
- (2018) Jenni A. Hayward et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis
- (2018) Si Ming Man Nature Reviews Gastroenterology & Hepatology
- ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
- (2018) Bettina L. Lee et al. Scientific Reports
- Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome
- (2018) Julie Barsalou et al. Frontiers in Immunology
- The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses
- (2018) Damien Bierschenk et al. JOURNAL OF LEUKOCYTE BIOLOGY
- NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8
- (2017) Isabella Rauch et al. IMMUNITY
- The intra- and extracellular functions of ASC specks
- (2017) Bernardo S Franklin et al. IMMUNOLOGICAL REVIEWS
- Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
- (2017) Si Ming Man et al. IMMUNOLOGICAL REVIEWS
- The NLRC4 Inflammasome
- (2017) Joseph A. Duncan et al. IMMUNOLOGICAL REVIEWS
- Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition
- (2017) Scott W. Canna et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
- (2017) Leslie Freeman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection
- (2017) Weiwei Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cirtical role for Salmonella effector SopB in regulating inflammasome activation
- (2017) Gui-Qiu Hu et al. MOLECULAR IMMUNOLOGY
- Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation With Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites
- (2017) Jiancong Liang et al. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
- Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome
- (2017) Valeria M. Reyes Ruiz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion
- (2017) Jeannette L. Tenthorey et al. SCIENCE
- NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
- (2017) Randilea D. Nichols et al. Nature Communications
- Identification of a High-Frequency SomaticNLRC4Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection
- (2017) Yuri Kawasaki et al. Arthritis & Rheumatology
- NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma
- (2017) Xiangkun Wang et al. Cancer Medicine
- NLRC4 regulates caspase-1 and IL-1beta production in a CD11blowLy6Glow population of cells required for resistance to Pseudomonas aeruginosa keratitis
- (2017) Sharon A. McClellan et al. PLoS One
- Erythematous nodes, urticarial rash and arthralgias in a large pedigree withNLRC4-related autoinflammatory disease, expansion of the phenotype
- (2016) C.M.L. Volker-Touw et al. BRITISH JOURNAL OF DERMATOLOGY
- Inflammasome Complexes: Emerging Mechanisms and Effector Functions
- (2016) Vijay A.K. Rathinam et al. CELL
- Pig lacks functional NLRC4 and NAIP genes
- (2016) Chisato Sakuma et al. IMMUNOGENETICS
- The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation
- (2016) Xiaowei Wang et al. INFECTION AND IMMUNITY
- A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death
- (2016) Akhouri Kishore Raghawan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NLRC4 suppresses melanoma tumor progression independently of inflammasome activation
- (2016) Ann M. Janowski et al. JOURNAL OF CLINICAL INVESTIGATION
- NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo
- (2016) Isabella Rauch et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NLRP3 recruitment by NLRC4 duringSalmonellainfection
- (2016) Yan Qu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice
- (2016) Yue Zhao et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Pore-forming activity and structural autoinhibition of the gasdermin family
- (2016) Jingjin Ding et al. NATURE
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- (2016) Xing Liu et al. NATURE
- Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
- (2016) Ryan Kolb et al. Nature Communications
- Differential ASC Requirements Reveal a Key Role for Neutrophils and a Noncanonical IL-1β Response to Pseudomonas aeruginosa
- (2015) Yash R Patankar et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- The NAIP/NLRC4 inflammasomes
- (2015) Russell E Vance CURRENT OPINION IN IMMUNOLOGY
- Caspase-11: arming the guards against bacterial infection
- (2015) Irma Stowe et al. IMMUNOLOGICAL REVIEWS
- The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
- (2015) Yue Zhao et al. IMMUNOLOGICAL REVIEWS
- Regulation of inflammasome activation
- (2015) Si Ming Man et al. IMMUNOLOGICAL REVIEWS
- The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments
- (2015) Parimala R. Vajjhala et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epithelial NAIPs protect against colonic tumorigenesis
- (2015) Ramanjaneyulu Allam et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by FlagellatedLegionellaSpecies in Mouse Macrophages and In Vivo
- (2015) Daiane M. Cerqueira et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin
- (2015) Jens Kortmann et al. JOURNAL OF IMMUNOLOGY
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
- (2015) Magdalena Matusiak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
- (2015) Adam Denes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
- (2015) L. Zhang et al. SCIENCE
- Structural and biochemical basis for induced self-propagation of NLRC4
- (2015) Z. Hu et al. SCIENCE
- Differential expression of inflammasomes in lung cancer cell lines and tissues
- (2015) Hui Kong et al. TUMOR BIOLOGY
- Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
- (2015) Rongrong Liu et al. Oncotarget
- Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa
- (2014) Mikael E. Sellin et al. Cell Host & Microbe
- An inherited mutation inNLRC4causes autoinflammation in human and mice
- (2014) Akiko Kitamura et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes
- (2014) Jeannette L. Tenthorey et al. MOLECULAR CELL
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
- (2014) Neil Romberg et al. NATURE GENETICS
- An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
- (2014) Scott W Canna et al. NATURE GENETICS
- Actin polymerization as a key innate immune effector mechanism to controlSalmonellainfection
- (2014) Si Ming Man et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
- (2014) S. M. Man et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
- (2014) Kaiwen W. Chen et al. Cell Reports
- Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ
- (2014) Shiho Suzuki et al. PLoS Pathogens
- Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia
- (2013) Taylor S. Cohen et al. JOURNAL OF CLINICAL INVESTIGATION
- Salmonella Downregulates Nod-like Receptor Family CARD Domain Containing Protein 4 Expression To Promote Its Survival in B Cells by Preventing Inflammasome Activation and Cell Death
- (2013) A. Perez-Lopez et al. JOURNAL OF IMMUNOLOGY
- Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1 Production
- (2013) S. M. Man et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein
- (2013) M. Rayamajhi et al. JOURNAL OF IMMUNOLOGY
- NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen
- (2013) S Nordlander et al. Mucosal Immunology
- IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease
- (2013) Li Liu et al. NEUROBIOLOGY OF AGING
- Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
- (2013) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism
- (2013) Z. Hu et al. SCIENCE
- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
- (2013) J. A. Hagar et al. SCIENCE
- A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
- (2013) Michelle M Simon et al. GENOME BIOLOGY
- Sensing of microbial molecular patterns by Toll-like receptors
- (2012) Dong Hyun Song et al. IMMUNOLOGICAL REVIEWS
- Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
- (2012) F A Carvalho et al. Mucosal Immunology
- Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
- (2012) Jakob von Moltke et al. NATURE
- Phosphorylation of NLRC4 is critical for inflammasome activation
- (2012) Yan Qu et al. NATURE
- NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
- (2012) Luigi Franchi et al. NATURE IMMUNOLOGY
- NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells
- (2012) Andreas Kupz et al. NATURE IMMUNOLOGY
- Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota
- (2012) Janelle S Ayres et al. NATURE MEDICINE
- Differential Requirements for NAIP5 in Activation of the NLRC4 Inflammasome
- (2011) Karla L. Lightfield et al. INFECTION AND IMMUNITY
- Activation of NLRC4 by Flagellated Bacteria Triggers Caspase-1-Dependent and -Independent Responses To Restrict Legionella pneumophila Replication in Macrophages and In Vivo
- (2011) M. S. F. Pereira et al. JOURNAL OF IMMUNOLOGY
- The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
- (2011) Yue Zhao et al. NATURE
- Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
- (2011) Eric M. Kofoed et al. NATURE
- Non-canonical inflammasome activation targets caspase-11
- (2011) Nobuhiko Kayagaki et al. NATURE
- The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis
- (2011) Marcelo S. F. Pereira et al. Frontiers in Microbiology
- Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
- (2010) Yatender Kumar et al. BIOCHEMICAL JOURNAL
- Pore Formation Triggered by Legionella spp. Is an Nlrc4 Inflammasome-Dependent Host Cell Response That Precedes Pyroptosis
- (2010) T. N. Silveira et al. INFECTION AND IMMUNITY
- The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
- (2010) Irving C. Allen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella
- (2010) Petr Broz et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
- (2010) Edward A Miao et al. NATURE IMMUNOLOGY
- Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
- (2010) B. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
- (2010) E. A. Miao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins
- (2009) Olivier Danot et al. STRUCTURE
- The NLR Gene Family: A Standard Nomenclature
- (2008) Jenny P.-Y. Ting et al. IMMUNITY
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes
- (2008) Mohamed Lamkanfi et al. MOLECULAR & CELLULAR PROTEOMICS
- Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
- (2008) Karla L Lightfield et al. NATURE IMMUNOLOGY
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