A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

(2015) Magdalena Matusiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

(2015) Christoph A. Diebolder et al.   STRUCTURE

Differential expression of inflammasomes in lung cancer cell lines and tissues

(2015) Hui Kong et al.   TUMOR BIOLOGY

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

An inherited mutation inNLRC4causes autoinflammation in human and mice

(2014) Akiko Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

Biochemical regulation of the inflammasome

(2012) Jennifer K. Dowling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Differential Requirements for NAIP5 in Activation of the NLRC4 Inflammasome

(2011) Karla L. Lightfield et al.   INFECTION AND IMMUNITY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death

(2010) Yatender Kumar et al.   BIOCHEMICAL JOURNAL

FADD: a regulator of life and death

(2010) Léa Tourneur et al.   TRENDS IN IMMUNOLOGY

The CULt of Caspase-8 Ubiquitination

(2009) Miklós Békés et al.   CELL

The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription

(2008) Kavita P. Bhat et al.   MOLECULAR IMMUNOLOGY