Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

(2016) Swapnil Rohidas Shinde et al.   Nature Communications

Disruption of tubular Flcn expression as a mouse model for renal tumor induction

(2015) Jindong Chen et al.   KIDNEY INTERNATIONAL

A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

(2015) A. Minajigi et al.   SCIENCE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

(2014) Elaine A Dunlop et al.   Autophagy

Interdependent epidermal growth factor receptor signalling and trafficking

(2014) Sylwia Jones et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis

(2014) Imoh S. Okon et al.   JOURNAL OF CLINICAL INVESTIGATION

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

(2014) Steffen Durinck et al.   NATURE GENETICS

Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression

(2014) Joshua J. Steffan et al.   PLoS One

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion

(2013) H. J. k. Balderhaar et al.   JOURNAL OF CELL SCIENCE

Defective Axonal Transport of Rab7 GTPase Results in Dysregulated Trophic Signaling

(2013) K. Zhang et al.   JOURNAL OF NEUROSCIENCE

RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms

(2013) Jamie S. Rush et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Folliculin Delays Cell Cycle Progression through Late S and G2/M-Phases: Effect of Phosphorylation and Tumor Associated Mutations

(2013) Laura A. Laviolette et al.   PLoS One

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

(2012) Michael S. Nahorski et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

(2012) Hisashi Hasumi et al.   JNCI-Journal of the National Cancer Institute

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

(2012) Doug A. Medvetz et al.   PLoS One

Endosomal crosstalk: meeting points for signaling pathways

(2012) Máté Pálfy et al.   TRENDS IN CELL BIOLOGY

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability

(2011) Michael S. Nahorski et al.   HUMAN MUTATION

DENN Domain Proteins: Regulators of Rab GTPases

(2011) Andrea L. Marat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal

(2011) Tuanlao Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells

(2009) Helen M. Jopling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Birt-Hogg-Dubé syndrome: diagnosis and management

(2009) Fred H Menko et al.   LANCET ONCOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesis

(2009) T R Hartman et al.   ONCOGENE

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

(2009) Y. Hasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Fission Yeast Rab7 Homologs, Ypt7 and Ypt71, Play Antagonistic Roles in the Regulation of Vacuolar Morphology

(2009) Jun Kashiwazaki et al.   TRAFFIC

The UOK 257 cell line: a novel model for studies of the human Birt–Hogg–Dubé gene pathway

(2008) Youfeng Yang et al.   CANCER GENETICS AND CYTOGENETICS

Identification and characterization of a novel folliculin-interacting protein FNIP2

(2008) Hisashi Hasumi et al.   GENE

Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease

(2008) M. R. Spinosa et al.   JOURNAL OF NEUROSCIENCE

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

(2008) M. Baba et al.   JNCI-Journal of the National Cancer Institute

Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

(2008) Michael Zimmer et al.   MOLECULAR CELL

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

(2008) Y Takagi et al.   ONCOGENE