PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts

(2019) Xiaowen Xu et al.   BRITISH JOURNAL OF CANCER

LRRK1 phosphorylation of Rab7 at Ser-72 links trafficking of EGFR-containing endosomes to its effector RILP

(2019) Hiroshi Hanafusa et al.   JOURNAL OF CELL SCIENCE

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

(2018) Rafeeq Mir et al.   BIOCHEMICAL JOURNAL

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

(2018) Anetta Härtlova et al.   EMBO JOURNAL

A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

(2018) Subrata Debnath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

(2018) Ga Ram Jeong et al.   Molecular Neurodegeneration

LRRK2 kinase in Parkinson's disease

(2018) Dario R. Alessi et al.   SCIENCE

A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

(2018) Nicolai Bache et al.   MOLECULAR & CELLULAR PROTEOMICS

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

LRRK2 and Rab GTPases

(2018) Suzanne R. Pfeffer   BIOCHEMICAL SOCIETY TRANSACTIONS

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

(2018) Herschel S Dhekne et al.   eLife

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

(2018) J.-M. Heo et al.   Science Advances

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

ProteomicsDB

(2017) Tobias Schmidt et al.   NUCLEIC ACIDS RESEARCH

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2

(2016) Panagiotis S. Athanasopoulos et al.   BIOLOGICAL CHEMISTRY

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes

(2016) Hieng Chiong Tie et al.   MOLECULAR BIOLOGY OF THE CELL

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen

(2016) Rebecca S. Levin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

(2015) Y.-C. Lai et al.   EMBO JOURNAL

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

(2014) Bernd K. Gilsbach et al.   Frontiers in Molecular Neuroscience

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

(2013) Evy Lobbestael et al.   BIOCHEMICAL JOURNAL

Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 Is Required for Phosphatase Activity

(2013) Kan Tanoue et al.   BIOCHEMISTRY

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Regulation of Ribosomal Protein S6 Phosphorylation by Casein Kinase 1 and Protein Phosphatase 1

(2011) John A. Hutchinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kin-cohort analysis of LRRK2-G2019S penetrance in Parkinson's disease

(2011) Stefano Goldwurm et al.   MOVEMENT DISORDERS

A large-scale method to measure absolute protein phosphorylation stoichiometries

(2011) Ronghu Wu et al.   NATURE METHODS

Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers

(2011) C. Marras et al.   NEUROLOGY

PPM1H Is a p27 Phosphatase Implicated in Trastuzumab Resistance

(2011) S. T. Lee-Hoeflich et al.   Cancer Discovery

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L

(2010) Takeyuki Sugiura et al.   CANCER BIOLOGY & THERAPY

Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain)

(2010) Javier Ruiz-Martínez et al.   MOVEMENT DISORDERS

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans

(2010) Jinrong Feng et al.   YEAST

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

(2009) Karsten Melcher et al.   NATURE

Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors

(2009) Y. Ma et al.   SCIENCE

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY