Myeloid‐specific blockade of Notch signaling alleviates murine pulmonary fibrosis through regulating monocyte‐derived Ly6c lo MHCII hi alveolar macrophages recruitment and TGF‐β secretion

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

(2019) Svetoslav Chakarov et al.   SCIENCE

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

The role of macrophages in the resolution of inflammation

(2019) Satoshi Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease

(2019) Carolina Ballester-López et al.   EBioMedicine

Notch signaling via Wnt regulates the proliferation of alternative, CCR2-independent tumor-associated macrophages in hepatocellular carcinoma

(2019) Yu-Chen Ye et al.   CANCER RESEARCH

Monocyte-derived Alveolar Macrophages: The Dark Side of Lung Repair?

(2018) Alexandra C. McQuattie-Pimentel et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis

(2018) Alexandra L. McCubbrey et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Location or origin? What is critical for macrophage propagation of lung fibrosis?

(2018) Xiaofeng Zhou et al.   EUROPEAN RESPIRATORY JOURNAL

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrow-derived macrophage

(2018) Yali Jiang et al.   Protein & Cell

TGF-β Signaling in Lung Health and Disease

(2018) Akira Saito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages

(2017) Catherine Sabatel et al.   IMMUNITY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice

(2017) Peng-Fei Ma et al.   JOURNAL OF HEPATOLOGY

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages

(2017) Fei Huang et al.   Frontiers in Immunology

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

(2016) Jun-Long Zhao et al.   CANCER RESEARCH

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

IL-10-producing lung interstitial macrophages prevent neutrophilic asthma

(2016) Hideo Kawano et al.   INTERNATIONAL IMMUNOLOGY

Notch in fibrosis and as a target of anti-fibrotic therapy

(2016) Biao Hu et al.   PHARMACOLOGICAL RESEARCH

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages

(2015) S. L. Gibbings et al.   BLOOD

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Myeloid-specific disruption of recombination signal binding protein Jκameliorates hepatic fibrosis by attenuating inflammation through cylindromatosis in mice

(2014) Fei He et al.   HEPATOLOGY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Pulmonary macrophage transplantation therapy

(2014) Takuji Suzuki et al.   NATURE

An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation

(2014) Kae Won Cho et al.   Cell Reports

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

(2013) Alexander V. Misharin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Temporal and spatial characterization of mononuclear phagocytes in circulating, lung alveolar and interstitial compartments in a mouse model of bleomycin-induced pulmonary injury

(2013) Wen-Jie Ji et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Myeloid hypoxia-inducible factor 1α prevents airway allergy in mice through macrophage-mediated immunoregulation

(2012) M Toussaint et al.   Mucosal Immunology

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

(2011) Michael A. Gibbons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

(2010) Lei Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via Transforming Growth Factor–β–Smad3 Pathway

(2010) Kana Aoyagi-Ikeda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice

(2009) Denis Bedoret et al.   JOURNAL OF CLINICAL INVESTIGATION

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

(2009) Kamran Atabai et al.   JOURNAL OF CLINICAL INVESTIGATION

Hairy-Related Transcription Factors Inhibit Notch-Induced Smooth Muscle α-Actin Expression by Interfering With Notch Intracellular Domain/CBF-1 Complex Interaction With the CBF-1–Binding Site

(2008) Yuefeng Tang et al.   CIRCULATION RESEARCH