The whole is greater than the sum of its parts: at the intersection of order, disorder, and kinetochore function

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells

(2020) Amanda J. Broad et al.   JOURNAL OF CELL BIOLOGY

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

(2020) Robert T. Wimbish et al.   Frontiers in Cell and Developmental Biology

The right place at the right time: Aurora B kinase localization to centromeres and kinetochores

(2020) Amanda J. Broad et al.   Essays in Biochemistry

Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

(2020) Emanuele Roscioli et al.   Cell Reports

The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment

(2020) Robert T. Wimbish et al.   MOLECULAR BIOLOGY OF THE CELL

The binding of Borealin to microtubules underlies a tension independent kinetochore-microtubule error correction pathway

(2019) Prasad Trivedi et al.   Nature Communications

Centromere mechanical maturation during mammalian cell mitosis

(2019) Lauren A. Harasymiw et al.   Nature Communications

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore

(2019) Richard J. Smith et al.   Cell Reports

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

(2018) Vladimir A Volkov et al.   eLife

KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive

(2018) Rakhi Bajaj et al.   STRUCTURE

An engineered minimal chromosomal passenger complex reveals a role for INCENP/Sli15 spindle association in chromosome biorientation

(2017) Sarah Fink et al.   JOURNAL OF CELL BIOLOGY

Microtubule nucleation: beyond the template

(2017) Johanna Roostalu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

(2017) Rutger C. C. Hengeveld et al.   Nature Communications

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

(2017) Gang Zhang et al.   Nature Communications

Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips

(2017) Jonathan W Driver et al.   eLife

How the kinetochore couples microtubule force and centromere stretch to move chromosomes

(2016) Aussie Suzuki et al.   NATURE CELL BIOLOGY

Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

(2016) Janko Kajtez et al.   Nature Communications

Chromosome biorientation produces hundreds of piconewtons at a metazoan kinetochore

(2016) Anna A. Ye et al.   Nature Communications

Bistability of a coupled Aurora B kinase-phosphatase system in cell division

(2016) Anatoly V Zaytsev et al.   eLife

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

(2015) Rui Zhang et al.   CELL

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1

(2015) Eelco Tromer et al.   Genome Biology and Evolution

The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes

(2015) David M. Kern et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

Discovering centromere proteins: from cold white hands to the A, B, C of CENPs

(2015) William C. Earnshaw   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment

(2015) Zhen Dou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Regulation of kinetochore–microtubule attachments through homeostatic control during mitosis

(2014) Kristina M. Godek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

(2013) Hironori Funabiki et al.   CHROMOSOMA

KI Motifs of Human Knl1 Enhance Assembly of Comprehensive Spindle Checkpoint Complexes around MELT Repeats

(2013) Veronica Krenn et al.   CURRENT BIOLOGY

Conserved and divergent features of kinetochores and spindle microtubule ends from five species

(2013) J. Richard McIntosh et al.   JOURNAL OF CELL BIOLOGY

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity

(2013) Gina V. Caldas et al.   JOURNAL OF CELL BIOLOGY

A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation

(2013) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization

(2013) Christopher S. Campbell et al.   NATURE

Kinetic framework of spindle assembly checkpoint signalling

(2013) Amalie E. Dick et al.   NATURE CELL BIOLOGY

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Determinants of robustness in spindle assembly checkpoint signalling

(2013) Stephanie Heinrich et al.   NATURE CELL BIOLOGY

Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules

(2013) V. A. Volkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

(2013) Ivana Primorac et al.   eLife

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

(2012) Julien Espeut et al.   JOURNAL OF CELL BIOLOGY

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore

(2012) Z. Venkei et al.   Open Biology

KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint

(2011) Jessica S. Rosenberg et al.   CURRENT BIOLOGY

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Sds22 regulates aurora B activity and microtubule–kinetochore interactions at mitosis

(2010) Markus Posch et al.   JOURNAL OF CELL BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Intrakinetochore localization and essential functional domains of Drosophila Spc105

(2009) Ralf B Schittenhelm et al.   EMBO JOURNAL

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution

(2009) L. J. Holt et al.   SCIENCE

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Fibrils Connect Microtubule Tips with Kinetochores: A Mechanism to Couple Tubulin Dynamics to Chromosome Motion

(2008) J. Richard McIntosh et al.   CELL

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

Architecture and Flexibility of the Yeast Ndc80 Kinetochore Complex

(2008) Hong-Wei Wang et al.   JOURNAL OF MOLECULAR BIOLOGY