The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

(2020) Robert T. Wimbish et al.   Frontiers in Cell and Developmental Biology

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner

(2019) Jonathan Kuhn et al.   JOURNAL OF CELL BIOLOGY

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

(2019) Pim J Huis in 't Veld et al.   eLife

Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation

(2019) Duccio Conti et al.   eLife

Multitasking Ska in Chromosome Segregation: Its Distinct Pools Might Specify Various Functions

(2018) Qian Zhang et al.   BIOESSAYS

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore–microtubule attachments

(2018) Luke A. Helgeson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An optimized method for 3D fluorescence co-localization applied to human kinetochore protein architecture

(2018) Aussie Suzuki et al.   eLife

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

(2018) Tae Yeon Yoo et al.   eLife

Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment

(2017) Philip Auckland et al.   JOURNAL OF CELL BIOLOGY

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics

(2017) Keith F. DeLuca et al.   JOURNAL OF CELL BIOLOGY

She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain

(2017) Kari H. Ecklund et al.   Nature Communications

How the kinetochore couples microtubule force and centromere stretch to move chromosomes

(2016) Aussie Suzuki et al.   NATURE CELL BIOLOGY

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

(2016) Sushama Sivakumar et al.   eLife

Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain

(2016) Maria Alba Abad et al.   Scientific Reports

Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity

(2015) Anatoly V. Zaytsev et al.   MOLECULAR BIOLOGY OF THE CELL

Stable kinetochore–microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells

(2015) Eric C. Tauchman et al.   Nature Communications

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

(2015) Banafsheh Etemad et al.   Nature Communications

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

The spindle and kinetochore–associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit

(2014) Sushama Sivakumar et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic spindle multipolarity without centrosome amplification

(2014) Helder Maiato et al.   NATURE CELL BIOLOGY

Structural basis for microtubule recognition by the human kinetochore Ska complex

(2014) Maria Alba Abad et al.   Nature Communications

Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexes

(2013) Fabienne Lampert et al.   JOURNAL OF CELL BIOLOGY

The KMN protein network - chief conductors of the kinetochore orchestra

(2013) D. Varma et al.   JOURNAL OF CELL SCIENCE

Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation

(2013) D. K. Cheerambathur et al.   SCIENCE

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

A Redundant Function for the N-Terminal Tail of Ndc80 in Kinetochore-Microtubule Interaction in Saccharomyces cerevisiae

(2012) P. B. Demirel et al.   GENETICS

Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction

(2012) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores

(2012) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface

(2012) A. Arockia Jeyaprakash et al.   MOLECULAR CELL

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore–microtubule attachment

(2012) Dileep Varma et al.   NATURE CELL BIOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multimodal microtubule binding by the Ndc80 kinetochore complex

(2012) Gregory M Alushin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ndc80 kinetochore complex directly modulates microtubule dynamics

(2012) N. T. Umbreit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase

(2011) John R. Daum et al.   CURRENT BIOLOGY

Structural organization of the kinetochore–microtubule interface

(2011) Jennifer G. DeLuca et al.   CURRENT OPINION IN CELL BIOLOGY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

(2011) John G. Tooley et al.   MOLECULAR BIOLOGY OF THE CELL

The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore–microtubule attachment in mitosis

(2011) Lynsie J.R. Sundin et al.   MOLECULAR BIOLOGY OF THE CELL

Abnormal Kinetochore-Generated Pulling Forces from Expressing a N-Terminally Modified Hec1

(2011) Marta Mattiuzzo et al.   PLoS One

Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest

(2011) Deanna Stevens et al.   PLoS One

Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores

(2010) Jens C. Schmidt et al.   JOURNAL OF CELL BIOLOGY

The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex

(2010) Fabienne Lampert et al.   JOURNAL OF CELL BIOLOGY

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B

(2010) Jerry F. Tien et al.   JOURNAL OF CELL BIOLOGY

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis

(2009) John R. Daum et al.   CURRENT BIOLOGY

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

Connecting with Ska, a key complex at the kinetochore–microtubule interface

(2009) Geoffrey J Guimaraes et al.   EMBO JOURNAL

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

(2009) Stefan Kemmler et al.   EMBO JOURNAL

Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division

(2009) Mirko Theis et al.   EMBO JOURNAL

RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment

(2009) J. A. Raaijmakers et al.   JOURNAL OF CELL SCIENCE

Hec1 Contributes to Mitotic Centrosomal Microtubule Growth for Proper Spindle Assembly through Interaction with Hice1

(2009) Guikai Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Kinetochore-Microtubule Attachment Relies on the Disordered N-Terminal Tail Domain of Hec1

(2008) Geoffrey J. Guimaraes et al.   CURRENT BIOLOGY

Kinetochore Attachments Require an Interaction between Unstructured Tails on Microtubules and Ndc80Hec1

(2008) Stephanie A. Miller et al.   CURRENT BIOLOGY

Orientation and structure of the Ndc80 complex on the microtubule lattice

(2008) Elizabeth M. Wilson-Kubalek et al.   JOURNAL OF CELL BIOLOGY

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY