Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachment

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling

(2015) Pavithra Aravamudhan et al.   NATURE CELL BIOLOGY

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

(2014) Veronica Rodriguez-Bravo et al.   CELL

The dynamic protein Knl1 - a kinetochore rendezvous

(2014) P. Ghongane et al.   JOURNAL OF CELL SCIENCE

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

(2014) Xinghui Wang et al.   PLoS One

Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore

(2013) Tongge Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

(2013) Wilco Nijenhuis et al.   JOURNAL OF CELL BIOLOGY

Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast

(2013) R. E. Meyer et al.   SCIENCE

Tracking spindle checkpoint signals from kinetochores to APC/C

(2013) Luying Jia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

(2013) Ivana Primorac et al.   eLife

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

(2012) Philippe Thebault et al.   BIOCHEMICAL JOURNAL

CDK-Dependent Potentiation of MPS1 Kinase Activity Is Essential to the Mitotic Checkpoint

(2012) Violeta Morin et al.   CURRENT BIOLOGY

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores

(2012) S. Heinrich et al.   JOURNAL OF CELL SCIENCE

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

On the molecular mechanisms of mitotic kinase activation

(2012) R. Bayliss et al.   Open Biology

Probing thein vivofunction of Mad1:C-Mad2 in the spindle assembly checkpoint

(2011) Luca L Fava et al.   EMBO JOURNAL

Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases

(2011) Semin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

(2011) Zhen Dou et al.   PLoS One

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin

(2010) Xia Ding et al.   CELL RESEARCH

A chemical tool box defines mitotic and interphase roles for Mps1 kinase

(2010) Weijie Lan et al.   JOURNAL OF CELL BIOLOGY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

(2010) Tale Sliedrecht et al.   PLoS One

Aurora B kinase activation requires survivin priming phosphorylation by PLK1

(2010) Youjun Chu et al.   Journal of Molecular Cell Biology

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

(2009) Stefan Kemmler et al.   EMBO JOURNAL

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1

(2009) S. Elowe et al.   JOURNAL OF CELL SCIENCE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS