Epigenetic Modifications and Therapy in Chronic Obstructive Pulmonary Disease (COPD): An Update Review

LncRNAs NR-026690 and ENST00000447867 are upregulated in CD4+ T cells in patients with acute exacerbation of COPD

(2019) Xuefei Qi et al.   International Journal of Chronic Obstructive Pulmonary Disease

Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

(2019) Mi Kyeong Lee et al.   Clinical Epigenetics

Cathelicidin LL-37 restoring glucocorticoid function in smoking and lipopolysaccharide-induced airway inflammation in rats

(2019) Jian-Zhen Weng et al.   CHINESE MEDICAL JOURNAL

One functional variant in the 3′‐untranslated region of TLR4 is associated with the elevated risk of ventilator‐associated pneumonia in the patients with chronic obstructive pulmonary disease

(2019) Xiaoyun Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of epigenetic changes in preeclampsia

(2019) Amin Kamrani et al.   BIOFACTORS

Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease

(2019) Hong Peng et al.   EXPERIMENTAL LUNG RESEARCH

Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor κB Axis in Macrophages and Mice Lungs

(2019) Nan Ma et al.   PATHOBIOLOGY

Role of miRNA-181a-2-3p in cadmium-induced inflammatory responses of human bronchial epithelial cells

(2019) Jeeyoung Kim et al.   Journal of Thoracic Disease

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis

(2019) Rim S.J. Sarker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Toxicological effects of ambient fine (PM2.5-0.18) and ultrafine (PM0.18) particles in healthy and diseased 3D organo-typic mucocilary-phenotype models

(2019) J. Sotty et al.   ENVIRONMENTAL RESEARCH

Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

(2019) Andreas Keller et al.   Cells

Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD

(2019) Adel Mohamed et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice

(2019) Jingjing Ding et al.   LIFE SCIENCES

MicroRNA Dysregulation in Pulmonary Arteries from COPD: Relationships with Vascular Remodeling

(2018) Melina M Musri et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HDAC2 Suppresses IL17A-Mediated Airway Remodeling in Human and Experimental Modeling of COPD

(2018) Tianwen Lai et al.   CHEST

MiR-27-3p regulates TLR2/4-dependent mouse alveolar macrophage activation by targetting PPARγ

(2018) Dan Wang et al.   CLINICAL SCIENCE

Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells

(2018) Maria Gabriella Matera et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells

(2018) Serena Di Vincenzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long Noncoding RNAs and mRNA Regulation in Peripheral Blood Mononuclear Cells of Patients with Chronic Obstructive Pulmonary Disease

(2018) Xiaoyan Qu et al.   MEDIATORS OF INFLAMMATION

The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach

(2018) Dan-Dan Wu et al.   PHARMACOLOGY & THERAPEUTICS

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

(2018) Rachel L. Clifford et al.   Clinical Epigenetics

Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension

(2018) Selvi Asker et al.   International Journal of Chronic Obstructive Pulmonary Disease

Theophylline inhibits cigarette smoke-induced inflammation in skeletal muscle by upregulating HDAC2 expression and decreasing NF-κB activation

(2018) Yanfei Bin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miRNA-206 regulates human pulmonary microvascular endothelial cell apoptosis via targeting in chronic obstructive pulmonary disease

(2018) Ying Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-186 is associated with hypoxia-inducible factor-1α expression in chronic obstructive pulmonary disease

(2018) Li Lin et al.   Molecular Genetics & Genomic Medicine

miR-483-5p plays a protective role in chronic obstructive pulmonary disease

(2017) Zhenyu Shen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions

(2017) Younis Mohammad Hazari et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease

(2017) Jun Ikari et al.   PLoS One

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

(2017) J. Song et al.   Clinical Epigenetics

DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD

(2017) Isaac K. Sundar et al.   Clinical Epigenetics

miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting

(2017) Martin Connolly et al.   Journal of Cachexia Sarcopenia and Muscle

Peripheral leukocyte microRNAs as novel biomarkers for COPD

(2017) Ruiying Wang et al.   International Journal of Chronic Obstructive Pulmonary Disease

Cystic Fibrosis Lung Immunity: The Role of the Macrophage

(2016) Emanuela M. Bruscia et al.   Journal of Innate Immunity

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Epigenetic Modifications and Therapy in Multiple Sclerosis

(2016) Saeed Aslani et al.   NEUROMOLECULAR MEDICINE

The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline

(2016) Annika Karch et al.   RESPIRATORY MEDICINE

Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis

(2016) Jameel Barnawi et al.   RESPIROLOGY

Curcumin modulates the effect of histone modification on the expression of chemokines by type II alveolar epithelial cells in a rat COPD model

(2016) Xingli Gan et al.   International Journal of Chronic Obstructive Pulmonary Disease

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

(2015) Hitomi Takada et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of culture conditions on microRNA expression in primary adult control and COPD lung fibroblasts in vitro

(2015) Jun Ikari et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Epigenetic targets for novel therapies of lung diseases

(2015) Brian S. Comer et al.   PHARMACOLOGY & THERAPEUTICS

SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes

(2015) Sun-Yee Kim et al.   PLoS One

Global burden of COPD

(2015) José Luis López-Campos et al.   RESPIROLOGY

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)

(2015) Jameel Barnawi et al.   PLoS One

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

(2014) M. Adam et al.   EUROPEAN RESPIRATORY JOURNAL

Ventilator-associated pneumonia: present understanding and ongoing debates

(2014) Girish B. Nair et al.   INTENSIVE CARE MEDICINE

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels

(2014) Fatemat Hassan et al.   RESPIRATORY RESEARCH

Role of alveolar macrophages in chronic obstructive pulmonary disease

(2014) Ross Vlahos   Frontiers in Immunology

Associations of Ambient Air Pollution with Chronic Obstructive Pulmonary Disease Hospitalization and Mortality

(2013) Wen Qi Gan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Foxa2 Regulates Leukotrienes to Inhibit Th2-mediated Pulmonary Inflammation

(2013) Xiaoju Tang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

(2013) Emily A. Vucic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Long noncoding RNAs and the genetics of cancer

(2013) S W Cheetham et al.   BRITISH JOURNAL OF CANCER

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Immune and Genetic Mechanisms in COPD: Possible Targets for Therapeutic Interventions

(2013) Eleni G. Tzortzaki et al.   CURRENT DRUG TARGETS

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages

(2013) Yang Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Increased skeletal muscle-specific microRNA in the blood of patients with COPD

(2013) Anna Donaldson et al.   THORAX

Oxidative Stress and Chromatin Remodeling in Chronic Obstructive Pulmonary Disease and Smoking-Related Diseases

(2012) Isaac K. Sundar et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

miR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma, Where It Interferes with Cell-Cycle Regulation

(2012) J. Cai et al.   CANCER RESEARCH

The 2011 revision of the global strategy for the diagnosis, management and prevention of COPD (GOLD) - why and what?

(2012) Jørgen Vestbo et al.   Clinical Respiratory Journal

Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy

(2012) Benjamin B. Davis et al.   EUROPEAN RESPIRATORY JOURNAL

Mir-206 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Differentiation

(2012) Samuel Jalali et al.   PLoS One

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung Morphogenesis

(2012) Ralph Epaud et al.   PLoS One

Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle homeostasis in mice

(2012) V. Moresi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of microRNAs in arterial remodelling

(2012) Maliheh Nazari-Jahantigh et al.   THROMBOSIS AND HAEMOSTASIS

Epigenetic Control of Gene Expression in the Lung

(2011) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function

(2011) Weiliang Qiu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Function and mechanisms of TSLP/TSLPR complex in asthma and COPD

(2011) N. S. Redhu et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Genetic variations in detoxification enzymes and HIF-1α in Japanese patients with COPD

(2011) Andika Chandra Putra et al.   Clinical Respiratory Journal

Early detection of COPD is important for lung cancer surveillance

(2011) Yasuo Sekine et al.   EUROPEAN RESPIRATORY JOURNAL

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

Specific peripheral miRNA profiles for distinguishing lung cancer from COPD

(2011) Petra Leidinger et al.   LUNG CANCER

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

(2010) Camille Doe et al.   CHEST

Automethylation of CARM1 allows coupling of transcription and mRNA splicing

(2010) Peter Kuhn et al.   NUCLEIC ACIDS RESEARCH

Simvastatin Inhibits Airway Hyperreactivity

(2009) Amir A. Zeki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2

(2009) Grace O. Osoata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Current Perspectives on Role of Chromatin Modifications and Deacetylases in Lung Inflammation in COPD

(2009) Saravanan Rajendrasozhan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Characterization of human epigenomes

(2009) Zhibin Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chronic obstructive pulmonary disease in non-smokers

(2009) Sundeep S Salvi et al.   LANCET

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

OralN-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats

(2009) Shan CAI et al.   RESPIROLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Lung Fibroblast Repair Functions in Patients with Chronic Obstructive Pulmonary Disease Are Altered by Multiple Mechanisms

(2008) Shinsaku Togo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Rosiglitazone and 15-Deoxy-Δ12,14-Prostaglandin J2, PPARγ Agonists, Differentially Regulate Cigarette Smoke-Mediated Pro-Inflammatory Cytokine Release in Monocytes/Macrophages

(2007) Samuel Caito et al.   ANTIOXIDANTS & REDOX SIGNALING