SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells

Interleukin-1α drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD

(2016) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD

(2016) Irene H. Heijink et al.   EUROPEAN RESPIRATORY JOURNAL

Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells

(2016) E. Pace et al.   EXPERIMENTAL GERONTOLOGY

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

(2016) J. R. Baker et al.   Scientific Reports

CCL20 and Beta-Defensin 2 Production by Human Lung Epithelial Cells and Macrophages in Response to Brucella abortus Infection

(2015) M. Soledad Hielpos et al.   PLoS One

Abnormalities in Airway Epithelial Junction Formation in Chronic Obstructive Pulmonary Disease

(2014) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transcriptional regulation of CCL20 expression

(2014) Lifang Zhao et al.   MICROBES AND INFECTION

Generation and Dietary Modulation of Anti-Inflammatory Electrophilic Omega-3 Fatty Acid Derivatives

(2014) Chiara Cipollina et al.   PLoS One

Comparative cytoprotective effects of carbocysteine and fluticasone propionate in cigarette smoke extract-stimulated bronchial epithelial cells

(2013) Elisabetta Pace et al.   CELL STRESS & CHAPERONES

DAMPs activating innate and adaptive immune responses in COPD

(2013) S D Pouwels et al.   Mucosal Immunology

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

(2013) Roland F Hoffmann et al.   RESPIRATORY RESEARCH

Carbocysteine regulates innate immune responses and senescence processes in cigarette smoke stimulated bronchial epithelial cells

(2013) Elisabetta Pace et al.   TOXICOLOGY LETTERS

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathobiologic Mechanisms of Chronic Obstructive Pulmonary Disease

(2012) Anthony Tam et al.   MEDICAL CLINICS OF NORTH AMERICA

Beta Defensin-2 Is Reduced in Central but Not in Distal Airways of Smoker COPD Patients

(2012) Elisabetta Pace et al.   PLoS One

Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A

(2012) Shyamala Ganesan et al.   THORAX

Aging, Inflammation, and Emphysema

(2011) William MacNee   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome

(2011) E. Mortaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

N -Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling

(2011) Thommie Karlsson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

FOXO3 Modulates Endothelial Gene Expression and Function by Classical and Alternative Mechanisms

(2010) Tobias Czymai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

(2009) Wen Zhou et al.   GASTROENTEROLOGY

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

Aging and induced senescence as factors in the pathogenesis of lung emphysema

(2008) Stefan Karrasch et al.   RESPIRATORY MEDICINE

Characterization of Side Population Cells from Human Airway Epithelium

(2008) Tillie-Louise Hackett et al.   STEM CELLS