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Title
DNA replication stress: from molecular mechanisms to human disease
Authors
Keywords
DNA replication, Replicative stress, Replication fork, Replication origin, Checkpoint, DNA repair
Journal
CHROMOSOMA
Volume 126, Issue 1, Pages 1-15
Publisher
Springer Nature
Online
2016-01-21
DOI
10.1007/s00412-016-0573-x
References
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- (2015) Sabine A.S. Langie et al. CARCINOGENESIS
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- (2015) Andres J. Lopez-Contreras et al. GENES & DEVELOPMENT
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- (2015) Marco Fumasoni et al. MOLECULAR CELL
- Structure of the eukaryotic MCM complex at 3.8 Å
- (2015) Ningning Li et al. NATURE
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- (2015) Franziska Bleichert et al. NATURE
- Regulated eukaryotic DNA replication origin firing with purified proteins
- (2015) Joseph T. P. Yeeles et al. NATURE
- Exploiting replicative stress to treat cancer
- (2015) Matthias Dobbelstein et al. NATURE REVIEWS DRUG DISCOVERY
- Replication fork reversal in eukaryotes: from dead end to dynamic response
- (2015) Kai J. Neelsen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
- (2015) M. Raschle et al. SCIENCE
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- (2015) C. Tomasetti et al. SCIENCE
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- (2015) Kimberly A. Rickman et al. Cell Reports
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- (2015) Kasper Fugger et al. Cell Reports
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- (2014) Deborah L. Croteau et al. Annual Review of Biochemistry
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- (2014) Marco Saponaro et al. CELL
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- (2014) Jochen Schulze et al. CELL CYCLE
- DNA Replication and Oncogene-Induced Replicative Stress
- (2014) Stephanie A. Hills et al. CURRENT BIOLOGY
- The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
- (2014) Stephan Hamperl et al. DNA REPAIR
- Replication stress and cancer: It takes two to tango
- (2014) Emilio Lecona et al. EXPERIMENTAL CELL RESEARCH
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- Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
- (2014) Julie Sollier et al. MOLECULAR CELL
- XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4
- (2014) Daisy Klein Douwel et al. MOLECULAR CELL
- Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
- (2014) Johanna Flach et al. NATURE
- BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
- (2014) Vaibhav Bhatia et al. NATURE
- Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
- (2014) Constance Alabert et al. NATURE CELL BIOLOGY
- Understanding nucleotide excision repair and its roles in cancer and ageing
- (2014) Jurgen A. Marteijn et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2014) Michele Giannattasio et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2014) Thomas A. Guilliam et al. NUCLEIC ACIDS RESEARCH
- Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
- (2014) Y Aye et al. ONCOGENE
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- (2014) A. Aguilera et al. Cold Spring Harbor Perspectives in Biology
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- (2014) A. H. Bizard et al. Cold Spring Harbor Perspectives in Biology
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- (2012) Tomás Aparicio et al. CHROMOSOMA
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- (2012) Marta B Davidson et al. EMBO JOURNAL
- dNTP pools determine fork progression and origin usage under replication stress
- (2012) Jérôme Poli et al. EMBO JOURNAL
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- (2012) Maikel Castellano-Pozo et al. EMBO REPORTS
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- (2012) J. E. Sale JOURNAL OF CELL SCIENCE
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- (2012) Alberto Ciccia et al. MOLECULAR CELL
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- (2012) R M Jones et al. ONCOGENE
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- (2012) Bruce N. Bagley et al. PLoS Genetics
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- (2011) Rodrigo Bermejo et al. CELL
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- (2011) Pengfei Liu et al. CELL
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- (2011) Assaf C. Bester et al. CELL
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- (2011) Belén Gómez-González et al. EMBO JOURNAL
- Genome-wide depletion of replication initiation events in highly transcribed regions
- (2011) M. M. Martin et al. GENOME RESEARCH
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- (2011) Anne Blumrich et al. HUMAN MOLECULAR GENETICS
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- (2011) Anne Helmrich et al. MOLECULAR CELL
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- (2011) Lamia Wahba et al. MOLECULAR CELL
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- (2011) Tsuyoshi Kawabata et al. MOLECULAR CELL
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- (2011) Efrat Ozeri-Galai et al. MOLECULAR CELL
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- (2011) Anne Letessier et al. NATURE
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- (2011) Duane L Guernsey et al. NATURE GENETICS
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- (2011) Louise S Bicknell et al. NATURE GENETICS
- Mutations in the pre-replication complex cause Meier-Gorlin syndrome
- (2011) Louise S Bicknell et al. NATURE GENETICS
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- (2010) Hisao Masai et al. Annual Review of Biochemistry
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- (2010) Franca Pelliccia et al. CANCER LETTERS
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- (2010) Georgios I. Karras et al. CELL
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- (2010) Julia M. Sidorova et al. CELL CYCLE
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- (2010) E. Guillou et al. GENES & DEVELOPMENT
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- (2010) J. R. Lydeard et al. GENES & DEVELOPMENT
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- (2010) Min Huang et al. MOLECULAR CELL
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- (2010) Yasukazu Daigaku et al. NATURE
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- (2010) Jaime Lopez-Mosqueda et al. NATURE
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- (2010) Philip Zegerman et al. NATURE
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- (2010) Eva Petermann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2010) Yoshitami Hashimoto et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2010) Fabio Vanoli et al. PLoS Genetics
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- (2009) Regina Waltes et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2009) Rodrigo Bermejo et al. CELL
- Tipin/Tim1/And1 protein complex promotes Polα chromatin binding and sister chromatid cohesion
- (2009) Alessia Errico et al. EMBO JOURNAL
- A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome
- (2009) Agnieszka Gambus et al. EMBO JOURNAL
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- (2009) Sigal Shachar et al. EMBO JOURNAL
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- (2009) Oscar Fernandez-Capetillo EMBO REPORTS
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- (2009) J. Yuan et al. GENES & DEVELOPMENT
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- (2009) C. E. Bansbach et al. GENES & DEVELOPMENT
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- (2009) Joshua A. Sommers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Sandie Tuduri et al. NATURE CELL BIOLOGY
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- (2009) Sanford D. Markowitz et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) Jan H.J. Hoeijmakers NEW ENGLAND JOURNAL OF MEDICINE
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- (2009) Ivan V. Rosado et al. NUCLEIC ACIDS RESEARCH
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- (2009) P. Knipscheer et al. SCIENCE
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- (2008) Markus Räschle et al. CELL
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- (2008) Kristina Trenz et al. EMBO JOURNAL
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- (2008) Isabelle Morin et al. EMBO JOURNAL
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- (2008) M. Segurado et al. GENES & DEVELOPMENT
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- (2008) Arkaitz Ibarra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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